珠子草素

Niranthin

	产品编号	CFN98798
	CAS编号	50656-77-4
	分子式 = 分子量	C₂₄H₃₂O₇ = 432.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The herbs of Phyllanthus amarus
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产品名称	产品编号	CAS编号	包装	QQ客服
珠子草素	CFN98798	50656-77-4	1mg	QQ客服：215959384
珠子草素	CFN98798	50656-77-4	5mg	QQ客服：215959384
珠子草素	CFN98798	50656-77-4	10mg	QQ客服：215959384
珠子草素	CFN98798	50656-77-4	20mg	QQ客服：215959384

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Description:

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.

Targets:

HBV | Topoisomerase | PAFR | Antifection

In vitro:

J Ethnopharmacol. 2014 Sep 11;155(2):1061-7.

In vitro and in vivo anti-hepatitis B virus activities of the lignan niranthin isolated from Phyllanthus niruri L.[Pubmed: 25009077]

This study was designed to evaluate the anti-hepatitis B virus activity of Niranthin using HepG2.2.15 cells and duck hepatitis B virus (DHBV) infected ducks as in vitro and in vivo models.
METHODS AND RESULTS:
: Niranthin was isolated from Phyllanthus niruri L. (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hepatitis B virus activity was evaluated both in vitro and in vivo. The human HBV-transfected liver cell line HepG2.2.15 was used in vitro assay. And the in vivo anti-hepatitis B virus activity was evaluated on the expression of HBV replication, HBsAg, HBeAg, ALT and AST on day 0, 7, 14, 17 after Niranthin was dosed intragastricly (i.g.) once a day for 14 days at the dosages of 25, 50 and 100 mg/kg/day in the duck hepatitis B virus (DHBV) infected ducks. In the human HBV-transfected liver cell line HepG2.2.15, the secretion of HBsAg and HBeAg were significantly decreased after treatment with Niranthin for 144 h, with IC50 values for HBsAg of 15.6 µM, IC50 values for HBeAg of 25.1 µM. In DHBV-infected ducklings, Niranthin significantly reduced the serum DHBV DNA, HBsAg, HBeAg, ALT and AST. Furthermore, analysis of the liver pathological changes confirmed the hepatoprotective effect of Niranthin.
CONCLUSIONS:
The experimental data demonstrated that Niranthin exhibits anti-hepatitis B virus activity both in vitro and in vivo. values for HBsAg of 15.6 µM, IC50 values for HBeAg of 25.1 µM. In DHBV-infected ducklings, niranthin significantly reduced the serum DHBV DNA, HBsAg, HBeAg, ALT and AST. Furthermore, analysis of the liver pathological changes confirmed the hepatoprotective effect of niranthin. CONCLUSION: The experimental data demonstrated that niranthin exhibits anti-hepatitis B virus activity both in vitro and in vivo.

In vivo:

EMBO Mol Med. 2012 Oct;4(10):1126-43.

The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice.[Pubmed: 23027614]

Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities.
METHODS AND RESULTS:
In the present study, we have shown for the first time that Niranthin is a potent anti-leishmanial agent. The compound induces topoisomerase I-mediated DNA-protein adduct formation inside Leishmania cells and triggers apoptosis by activation of cellular nucleases. We also show that Niranthin inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin interacts with DNA-protein binary complexes and thus stabilizes the 'cleavable complex' formation and subsequently inhibits the religation of cleaved strand. The compound inhibits the proliferation of Leishmania amastigotes in infected cultured murine macrophages with limited cytotoxicity to the host cells and is effective against antimony-resistant Leishmania parasites by modulating upregulated P-glycoprotein on host macrophages. Importantly, besides its in vitro efficacy, Niranthin treatment leads to a switch from a Th2- to a Th1-type immune response in infected BALB/c mice. The immune response causes production of nitric oxide, which results in almost complete clearance of the liver and splenic parasite burden after intraperitoneal or intramuscular administration of the drug.
CONCLUSIONS:
These findings can be exploited to develop Niranthin as a new drug candidate against drug-resistant leishmaniasis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
赤式-6-澳白木脂素; erythro-Austrobailignan-6	CFN95501	114127-24-1	C₂₀H₂₄O₄ = 328.4	10mg	QQ客服：215959384
Schineolignin B; Schineolignin B	CFN92717	1352185-26-2	C₂₂H₃₀O₅ = 374.5	5mg	QQ客服：1413575084
华中五脂素; Sphenanlignan	CFN95245	866347-36-6	C₂₁H₂₆O₅ = 358.4	5mg	QQ客服：215959384
Arisanschinin E; Arisanschinin E	CFN95221	1333378-33-8	C₂₁H₂₈O₅ = 360.5	5mg	QQ客服：1457312923
前五味子脂素; Pregomisin	CFN96694	66280-26-0	C₂₂H₃₀O₆ = 390.47	10mg	QQ客服：1457312923
脱水开环异落叶松树脂酚; Anhydrosecoisolariciresinol	CFN89236	29388-33-8	C₂₀H₂₄O₅ = 344.40	5mg	QQ客服：2056216494
4,4'-[[(2S,3S,4S)-四氢-2-甲氧基-3,4-呋喃二基]二(亚甲基)]二[2-甲氧基苯酚]; 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	CFN96711	1206464-65-4	C₂₁H₂₆O₆ = 374.43	5mg	QQ客服：1457312923
开环异落叶松树脂酚; Secoisolariciresinol	CFN98363	29388-59-8	C₂₀H₂₆O₆ = 362.4	10mg	QQ客服：1413575084
开环异落叶松树脂素一苷; Secoisolariciresinol monoglucoside	CFN96682	63320-67-2	C₂₆H₃₆O₁₁ = 524.56	5mg	QQ客服：1413575084
亚麻木酚素; Secoisolariciresinol Diglucoside	CFN99722	148244-82-0	C₃₂H₄₆O₁₆ = 686.71	20mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3121 mL	11.5607 mL	23.1214 mL	46.2428 mL	57.8035 mL
5 mM	0.4624 mL	2.3121 mL	4.6243 mL	9.2486 mL	11.5607 mL
10 mM	0.2312 mL	1.1561 mL	2.3121 mL	4.6243 mL	5.7803 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	0.9249 mL	1.1561 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.4624 mL	0.578 mL

珠子草素

Niranthin

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