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  • 新莪术二酮

    Neocurdione

    新莪术二酮
    产品编号 CFN93132
    CAS编号 108944-67-8
    分子式 = 分子量 C15H24O2 = 236.35
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma zedoaria
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    新莪术二酮 CFN93132 108944-67-8 1mg QQ客服:2159513211
    新莪术二酮 CFN93132 108944-67-8 5mg QQ客服:2159513211
    新莪术二酮 CFN93132 108944-67-8 10mg QQ客服:2159513211
    新莪术二酮 CFN93132 108944-67-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utah State University (USA)
  • Kyung Hee University (Korea)
  • University of the Basque Country (Spain)
  • The Institute of Cancer Research (United Kingdom)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Korea Food Research Institute(KFRI) (Korea)
  • Osmania University (India)
  • Medical University of South Carolina (USA)
  • Srinakharinwirot University (Thailand)
  • Cornell University (USA)
  • University of Zurich (Switzerland)
  • Lund University (Sweden)
  • Universidad Industrial de Santander (Colombia)
  • University of Perugia (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2019, 235:406-414
  • Phytochem Anal.2022, doi: 10.1002
  • Biomedicines.2021, 9(8):954.
  • Curr Res Virol Sci.2022, 3:100019.
  • Foods.2021, 10(11):2754.
  • Plants (Basel).2024, 13(6):868.
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Pharm Biol.2017, 55(1):360-366
  • Eur J Pharmacol.2021, 899:174010.
  • Int J Mol Sci.2021, 22(16):8641.
  • Metabolites.2020, 11(1):E11.
  • Foods.2021, 10(6):1378.
  • Antioxidants (Basel).2020, 9(7):581.
  • Nutrients.2017, 10(1)
  • Journal of Apiculture2023.38(3):249-254.
  • Molecules.2023, 28(8):3291.
  • Life Sci.2019, 216:259-270
  • Front Nutr.2023, 10:1168095.
  • Pharmacognosy Magazine2024, 20(2):632-645.
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Food Chem X.2024, 21:101127.
  • J Ethnopharmacol.2024, 318(Pt B):116961.
  • Int J Mol Sci.2023, 24(8):7442.
  • ...
  • 生物活性
    Description: Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. Neocurdione shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
    Targets: NO | TNF-α | Caspase
    In vitro:
    Evid Based Complement Alternat Med. 2013;2013:257108.
    In Vitro Morphological Assessment of Apoptosis Induced by Antiproliferative Constituents from the Rhizomes of Curcuma zedoaria.[Pubmed: 23762112 ]
    Bioassay-guided isolation of the active hexane fractions of Curcuma zedoaria led to the identification of five pure compounds, namely, curzerenone (1), Neocurdione (2), curdione (3), alismol (4), and zederone (5) and a mixture of sterols, namely, campesterol (6), stigmasterol (7), and β -sitosterol (8). Alismol has never been reported to be present in Curcuma zedoaria.
    METHODS AND RESULTS:
    All isolated compounds except (3) were evaluated for their cytotoxic activity against MCF-7, Ca Ski, and HCT-116 cancer cell lines and noncancer human fibroblast cell line (MRC-5) using neutral red cytotoxicity assay. Curzerenone and alismol significantly inhibited cell proliferation in human cancer cell lines MCF-7, Ca Ski, and HCT-116 in a dose-dependent manner. Cytological observations by an inverted phase contrast microscope and Hoechst 33342/PI dual-staining assay showed typical apoptotic morphology of cancer cells upon treatment with curzerenone and alismol. Both compounds induce apoptosis through the activation of caspase-3.
    CONCLUSIONS:
    It can thus be suggested that curzerenone and alismol are modulated by apoptosis via caspase-3 signalling pathway. The findings of the present study support the use of Curcuma zedoaria rhizomes in traditional medicine for the treatment of cancer-related diseases. Thus, two naturally occurring sesquiterpenoids, curzerenone and alismol, hold great promise for use in chemopreventive and chemotherapeutic strategies.
    In vivo:
    Biol Pharm Bull. 2002 May;25(5):627-31.
    Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha.[Pubmed: 12033504]
    The 80% aqueous acetone extract of Zedoariae Rhizoma was found to show a protective effect against D-galactosamine (D-GalN)/lipopolysaccharide-induced acute liver injury in mice.
    METHODS AND RESULTS:
    To clarify the active compounds, the principal constituents were examined and 11 sesquiterpenes (furanodiene, curdione, neocurdrione, dehydrocurdione, germacrone, 13-hydroxygermacrone, curcumenol, isocurcumenol, aerugidiol, zedoarondiol, and curcumenone) and a diarylheptanoid (curcumin) were found to inhibit the increase in serum aspartate aminotransaminase and alanine aminotransaminase at a dose of 50 mg/kg p.o. in agreement with the previous in vitro studies, except for dehydrocurdione, aerugidiol, and zedoarondiol. In particular, curdione, Neocurdione, curcumenol, and isocurcumenol potently inhibited the increase at a dose of 12.5 mg/kg p.o. Furthermore, the eight sesquiterpenes, furanodiene, curdione, Neocurdione, dehydrocurdione, germacrone, 13-hydroxygermacrone, curcumenol, and curcumenone, also showed a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.
    Bioorg Med Chem Lett. 1998 Feb 17;8(4):339-44.
    Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury.[Pubmed: 9871681]

    METHODS AND RESULTS:
    Hepatoprotective sesquiterpenes were isolated from the aqueous acetone extract of Zedoariae Rhizoma, the rhizome of Curcuma zedoaria ROSCOE (Zingiberaceae). Principal sesquiterpenes, furanodiene, germacrone, curdione, Neocurdione, curcumenol, isocurcumenol, aerugidiol, zedoarondiol, and curcumenone and curcumin were found to show potent protective effect on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver injury in mice.
    CONCLUSIONS:
    Plausible action mechanisms for their hepatoprotective activity were clarified on the basis of the inhibitory effect on D-GalN-induced cytotoxicity in primary cultured rat hepatocytes, LPS-induced NO production in cultured mouse peritoneal macrophages, and D-GalN/tumor necrosis factor-alpha (TNF-alpha)-induced liver injury in mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.231 mL 21.1551 mL 42.3101 mL 84.6203 mL 105.7753 mL
    5 mM 0.8462 mL 4.231 mL 8.462 mL 16.9241 mL 21.1551 mL
    10 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
    50 mM 0.0846 mL 0.4231 mL 0.8462 mL 1.6924 mL 2.1155 mL
    100 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    β-丙氨酸; beta-Alanine CFN70019 107-95-9 C3H7NO2 = 89.0 20mg QQ客服:1457312923
    Scutebata B; Scutebata B CFN99323 1207181-58-5 C35H39NO10 = 633.7 5mg QQ客服:215959384
    当药黄素; Swertisin CFN90621 6991-10-2 C22H22O10 = 446.4 10mg QQ客服:2159513211
    土槿甲酸D; Pseudolaric acid D CFN99249 115028-67-6 C20H30O3 = 318.5 5mg QQ客服:2056216494

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