一枝蒿庚素；准葛尔乌头碱

Napellonine

	产品编号	CFN90393
	CAS编号	509-24-0
	分子式 = 分子量	C₂₂H₃₁NO₃ = 357.49
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Alkaloids
	植物来源	The roots of Aconitumso ngoricum Popov
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
一枝蒿庚素；准葛尔乌头碱	CFN90393	509-24-0	10mg	QQ客服：1457312923
一枝蒿庚素；准葛尔乌头碱	CFN90393	509-24-0	20mg	QQ客服：1457312923
一枝蒿庚素；准葛尔乌头碱	CFN90393	509-24-0	50mg	QQ客服：1457312923
一枝蒿庚素；准葛尔乌头碱	CFN90393	509-24-0	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Calcutta University (India)

University of Liège (Belgium)

Biotech R&D Institute (USA)

Instituto de Investigaciones Agropecuarias (Chile)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Guangzhou Institutes of Biomedicine and Health (China)

Monash University (Australia)

Helmholtz Zentrum München (Germany)

Nanjing University of Chinese Medicine (China)

Mahatma Gandhi University (India)

University of Leipzig (Germany)

Chiang Mai University (Thailand)

Universidade Católica Portuguesa (Portugal)

Chang Gung University (Taiwan)

More...

Description:

Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

Targets:

FGFR4

In vivo:

Sci Rep. 2017 Jun 15;7(1):3569.

A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine.[Pubmed: 28620157 ]

We describe a novel biomembrane affinity sample pretreatment technique to quickly screen and preconcentrate active components from traditional Chinese medicine (TCM), which adopts cell membrane coated silica particles (CMCSPs) as affinity ligands which benefit the biomembrane's ability to maximize simulation of drug-receptor interactions in vivo.
METHODS AND RESULTS:
In this study, the prepared CMCSPs formed by irreversible adsorption of fibroblast growth factor receptor 4 (FGFR4) cell membrane on the surface of silica were characterized using different spectroscopic and imaging instruments. Drug binding experiments showed the excellent adsorption rate and adsorption capacity of FGFR4/CMCSPs compared with non-coated silica particles. The FGFR4/CMCSPs were used as solid-phase extraction sorbents to pretreat the TCM Aconitum szechenyianum Gay. The resultant FGFR4/CMCSPs exhibited good performance. In addition, high selectivity and recognition ability of the FGFR4/CMCSPs were determined by selectivity experiments. Four alkaloid were screened and identified, one of these alkaloid, Napellonine, showed favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
CONCLUSIONS:
The proposed cell membrane affinity sample pretreatment method is a reliable, effective and time-saving method for fast screening and enriching active compounds and can be extended to pretreat other TCMs as leading compounds resources.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
翠雀花定; Delgrandine	CFN89550	145237-05-4	C₄₁H₄₃NO₁₂ = 741.77	5mg	QQ客服：215959384
14-Dehydrodelcosine; 14-Dehydrodelcosine	CFN89547	1361-18-8	C₂₄H₃₇NO₇ = 451.55	5mg	QQ客服：1413575084
8-去乙酰基滇乌碱; Acoforestinine	CFN99502	110011-77-3	C₃₅H₅₁NO₁₀ = 645.79	20mg	QQ客服：215959384
8-去乙酰滇乌碱; 8-Deacetylyunaconitine	CFN89329	93460-55-0	C₃₃H₄₇NO₁₀ = 617.73	5mg	QQ客服：2159513211
滇乌头碱; Yunaconitine	CFN99503	70578-24-4	C₃₅H₄₉NO₁₁ = 659.77	20mg	QQ客服：1413575084
3-乙酰滇乌碱; 3-Acetylyunaconitine	CFN89362	80787-51-5	C₃₇H₅₁NO₁₂ = 701.80	5mg	QQ客服：215959384
草乌甲素; Bulleyaconitine A	CFN99720	107668-79-1	C₃₅H₄₉NO₁₀ = 643.8	20mg	QQ客服：3257982914
Carmichaenine D; Carmichaenine D	CFN89455	2065228-62-6	C₂₉H₃₉NO₇ = 513.62	5mg	QQ客服：1457312923
Carmichaenine C; Carmichaenine C	CFN89454	2065228-61-5	C₃₀H₄₁NO₇ = 527.64	5mg	QQ客服：2159513211
黄草乌碱丙; Foresaconitine	CFN93029	73870-35-6	C₃₅H₄₉NO₉ = 627.77	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7973 mL	13.9864 mL	27.9728 mL	55.9456 mL	69.932 mL
5 mM	0.5595 mL	2.7973 mL	5.5946 mL	11.1891 mL	13.9864 mL
10 mM	0.2797 mL	1.3986 mL	2.7973 mL	5.5946 mL	6.9932 mL
50 mM	0.0559 mL	0.2797 mL	0.5595 mL	1.1189 mL	1.3986 mL
100 mM	0.028 mL	0.1399 mL	0.2797 mL	0.5595 mL	0.6993 mL

一枝蒿庚素； 准葛尔乌头碱

Napellonine

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一枝蒿庚素；准葛尔乌头碱