Myzodendrone

	产品编号	CFN96954
	CAS编号	101705-37-7
	分子式 = 分子量	C₁₆H₂₂O₈ = 342.34
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The flowering stems of Vitex agnus-castus.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Myzodendrone	CFN96954	101705-37-7	1mg	QQ客服：3257982914
Myzodendrone	CFN96954	101705-37-7	5mg	QQ客服：3257982914
Myzodendrone	CFN96954	101705-37-7	10mg	QQ客服：3257982914
Myzodendrone	CFN96954	101705-37-7	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Complutense University of Madrid (Spain)

University of Wuerzburg (Germany)

Korea Institute of Oriental Medicine (Korea)

Shanghai University of TCM (China)

University of Toronto (Canada)

Martin Luther University of Halle-Wittenberg (Germany)

University Medical Center Mainz (Germany)

Amity University (India)

Aarhus University (Denmark)

University of Mysore (India)

University of Lodz (Poland)

Mahatma Gandhi University (India)

Research Unit Molecular Epigenetics (MEG) (Germany)

University of the Basque Country (Spain)

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Description:

Myzodendrone is a highly effective as free radical scavenger.

In vitro:

Phytother Res. 2005 Dec;19(12):1043-7.

Antioxidant and free radical scavenging activities of Misodendrum punctulatum, myzodendrone and structurally related phenols.[Pubmed: 16372370 ]

METHODS AND RESULTS:
The peroxyl radical scavenging activity of a dry methanol extract of Misodendrum punctulatum was determined by means of luminol-enhanced chemiluminescence assay, allowing to calculate the total reactive antioxidant potential (TRAP) index equal to 239 +/- 26 microm, expressed in Trolox equivalents. The flavan-3-ol catechin (1) and the phenylbutanone derivative Myzodendrone (2) were identified through assay-guided fractionation as active metabolites present in the extract, and their structures were elucidated by chemical and spectroscopic analysis. Three other structurally related synthetic phenols, dehydrozingerone (3), zingerone (4) and Myzodendrone aglycone (5), were also analysed using this method.
CONCLUSIONS:
Compounds 1 and 2 were highly effective as free radical scavengers (TRAP = 1257 microm and 1018 microm, respectively) when compared with Trolox (TRAP = 144 microm), used as a standard. Compounds 3 and 5 were also active showing TRAP values of 229 microm and 219 microm, respectively, similarly to that observed for the dry extract. On the other hand, 4 was inactive. Catechin (1) also reduced the production of thiobarbituric acid reactive substances (TBARS) in rat liver homogenates, with IC50 = 26 microg/mL, superior to that obtained for Trolox, IC50 = 73 microg/mL. Compounds 2 and 5 showed IC50 values > 1000 microg/mL, while no activity could be observed for 3, 4, or the extract.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4-氨基-4-甲基-2-戊酮; 4-Amino-4-methyl-2-pentanone	CFN00045	625-04-7	C₆H₁₃NO = 115.17	5mg	QQ客服：3257982914
β-隐黄素; beta-Cryptoxanthin	CFN70370	472-70-8	C₄₀H₅₆O = 552.9	5mg	QQ客服：2056216494
乙酸雷公藤内酯A; Wilforlide A acetate	CFN97336	84104-80-3	C₃₂H₄₈O₄ = 496.7	5mg	QQ客服：2159513211
杨梅素-3'-O-β-D-葡萄糖苷; Cannabiscitrin	CFN95278	520-14-9	C₂₁H₂₀O₁₃ = 480.4	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9211 mL	14.6054 mL	29.2107 mL	58.4215 mL	73.0268 mL
5 mM	0.5842 mL	2.9211 mL	5.8421 mL	11.6843 mL	14.6054 mL
10 mM	0.2921 mL	1.4605 mL	2.9211 mL	5.8421 mL	7.3027 mL
50 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.1684 mL	1.4605 mL
100 mM	0.0292 mL	0.1461 mL	0.2921 mL	0.5842 mL	0.7303 mL