葛根素芹菜糖苷

Mirificin

	产品编号	CFN90643
	CAS编号	103654-50-8
	分子式 = 分子量	C₂₆H₂₈O₁₃ = 548.49
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The roots of Pueraria lobata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
葛根素芹菜糖苷	CFN90643	103654-50-8	10mg	QQ客服：2159513211
葛根素芹菜糖苷	CFN90643	103654-50-8	20mg	QQ客服：2159513211
葛根素芹菜糖苷	CFN90643	103654-50-8	50mg	QQ客服：2159513211
葛根素芹菜糖苷	CFN90643	103654-50-8	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of the Basque Country (Spain)

Imperial College London (United Kingdom)

University of Toronto (Canada)

Centrum Menselijke Erfelijkheid (Belgium)

University of Limpopo (South Africa)

Martin Luther University of Halle-Wittenberg (Germany)

Massachusetts General Hospital (USA)

Universit?t Basel (Switzerland)

Shanghai Institute of Organic Chemistry (China)

University of Sao Paulo (Brazil)

Instituto de Investigaciones Agropecuarias (Chile)

Sri Ramachandra University (India)

Harvard University (USA)

University of Wollongong (Australia)

More...

In vitro:

Molecules. 2015 Oct 15;20(10):18704-16.

Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer.[Pubmed: 26501241]

Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal flora (HIF) and intestinal absorption deserves study.
METHODS AND RESULTS:
In this work TMF extract was incubated with human intestinal bacteria under anaerobic conditions and the changes in the twelve main constituents of TMF were then investigated. Their intestinal permeabilities, i.e., the transport capability across the intestinal brush border were investigated with a human colon carcinoma cell line (Caco-2) cell monolayer model to predict the absorption mechanism. Meanwhile, rapid HPLC-DAD methods were established for the assay. According to the biotransformation curves of the twelve constituents and the permeability coefficients, the intestinal absorption capacity of the typical compounds was elevated from the levels of 10(-7) cm/s to 10(-5) cm/s from those of the original compounds in TMF. Among them the main isoflavone glycosides puerarin (4), Mirificin (6) and daidzin (7) were transformed into the same aglycone, daidzein (10).
CONCLUSIONS:
Therefore it was predicted that the aglycone compounds might be the real active ingredients in TMF. The models used can represent a novel path for the TCM studies.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
青蒿素N; Arteannuin N	CFN98045	207446-92-2	C₁₅H₂₂O₃ = 250.3	5mg	QQ客服：2056216494
12-羟基异补骨脂酚; 12-Hydroxyisobakuchiol	CFN92702	178765-55-4	C₁₈H₂₄O₂ = 272.4	5mg	QQ客服：2056216494
雷美替胺; Ramelteon	CFN90021	166597-26-9	C₁₃H₂₁NO₂ = 259.34	5mg	QQ客服：2056216494
赤式-愈创木基甘油 beta-苏式-丁香树脂酚醚; erythro-Guaiacylglycerol beta-threo-syringylglycerol ether	CFN89032	1313434-74-0	C₂₁H₂₈O₁₀ = 440.44	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8232 mL	9.1159 mL	18.2319 mL	36.4637 mL	45.5797 mL
5 mM	0.3646 mL	1.8232 mL	3.6464 mL	7.2927 mL	9.1159 mL
10 mM	0.1823 mL	0.9116 mL	1.8232 mL	3.6464 mL	4.558 mL
50 mM	0.0365 mL	0.1823 mL	0.3646 mL	0.7293 mL	0.9116 mL
100 mM	0.0182 mL	0.0912 mL	0.1823 mL	0.3646 mL	0.4558 mL