In vivo: |
Journal of Chinese Medicinal Materials, 2007, 30(12):1558-1560. | Tissue distribution on methyl nonyl ketone of the volatile oil from Houttyunia cordata in mice.[Pubmed: 18422191] | To study the tissue distribution on methyl nonyl ketone of the volatile oil from Houttuynia cordata in mice in order to provide a guidance for the clinical trial. METHODS AND RESULTS: The concentrations of the volatile oil from Houttuynia cordata in biological samples were determined by GC method.Results:After a single oral dose of 5.0 g/kg volatile oil from Houttuynia cordata in mice, parent drug was mainly distributed in windpipe,intesting,liver,kidney,heart, blood,spleen,lung,brain,muscle;after 7 hours,parent drug of every tissue decreased over 90%. CONCLUSIONS: Parent drug mianly distributes in windpipe,intestine,liver,kidney.The experiment provides pharmacokinetic evidence for the rational administration and the further development of Houttuynia cordata. |
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