Info: Read More
  • 中药标准品生产商,产品定制服务
  • 罗汉松树脂酚

    Matairesinol

    罗汉松树脂酚
    产品编号 CFN98983
    CAS编号 580-72-3
    分子式 = 分子量 C20H22O6 = 358.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Wikstroemia indica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    罗汉松树脂酚 CFN98983 580-72-3 1mg QQ客服:1413575084
    罗汉松树脂酚 CFN98983 580-72-3 5mg QQ客服:1413575084
    罗汉松树脂酚 CFN98983 580-72-3 10mg QQ客服:1413575084
    罗汉松树脂酚 CFN98983 580-72-3 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hawaii Cancer Center (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Bonn (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Stanford University (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Chulalongkorn University (Thailand)
  • Universidade de Franca (Brazil)
  • Kyung Hee University (Korea)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Hamdard University (India)
  • University of Wuerzburg (Germany)
  • Pennsylvania State University (USA)
  • Tohoku University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Trop J Pharm Res.2023, 22(3):283-288.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Int J Mol Sci.2023, 24(3):2102.
  • Sci. Rep.2015, 14-23
  • Cancer Sci.2022, 113(4):1406-1416.
  • Biomedicines.2021, 9(8):996.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • Environ Toxicol.2021, doi: 10.1002
  • bioRxiv2021, 458409.
  • Front Pharmacol.2022, 13:883475.
  • Plants (Basel).2023, 12(1):163.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Int. J. of Food Properties2017, S108-S118
  • Polytechnic University of Catalonia2017, 105826
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • J Nat Prod.2022, 85(5):1351-1362.
  • Industrial Crops and Products2017, 95:286-295
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Pharm Biol.2022, 60(1):2040-2048.
  • Biomedicines.2022, 10(3):583.
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • ...
  • 生物活性
    Description: Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α in hypoxic HeLa cells.Matairesinol has anti-osteoporotic activity via p38/ERK-NFATc1 signaling, but not by way of anti-resorptive action. Matairesinol could markedly benefit TRAIL-based tumor therapies, including those aimed at prostate cancer.
    Targets: ROS | ATPase | p38MAPK | ERK | Akt | PI3K
    In vitro:
    Oncogene. 2010 Feb 11;29(6):898-908.
    Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis.[Pubmed: 19935713]
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to be selectively pro-apoptotic in cancer cells, with minimal toxicity to normal tissues. Although this feature makes TRAIL a promising anticancer agent, not all cancer cell types are sensitive to TRAIL-induced apoptosis despite abundant expression of TRAIL receptors. Thus, combinatorial treatments to sensitize tumor cells to TRAIL-induced apoptosis have been in the focus of extensive research. Dietary lignans have shown cancer preventive and antitumorigenic activity, but the mechanisms behind these effects are poorly known.
    METHODS AND RESULTS:
    Here we observed that of the three tested lignan molecules, matairesinol (MAT) was the most effective as a death receptor-sensitizing agent. MAT sensitized the androgen-dependent LNCaP cells to TRAIL-induced apoptosis both in the presence and absence of androgens. Treatment with MAT markedly decreased Akt activity, which has been implicated as a key signaling mechanism in the TRAIL resistance of LNCaP prostate cancer cells. The involvement of the pathway in the MAT-mediated sensitization was shown in rescue experiments using ectopic expression of constitutively active Akt.
    CONCLUSIONS:
    Owing to the high activity of phosphatidylinositol 3-kinase/Akt signaling in cancer, targeting this survival pathway with MAT could markedly benefit TRAIL-based tumor therapies, including those aimed at prostate cancer.
    Biosci Biotechnol Biochem. 2006 Aug;70(8):1934-40.
    Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol.[Pubmed: 16926506]
    The radical and superoxide scavenging activities of oxidized Matairesinols were examined.
    METHODS AND RESULTS:
    It could be assumed that the free benzylic position was important for higher radical scavenging activity. The different level of activity was observed between 7'-oxoMatairesinol (Mat 2) and 7-oxoMatairesinol (Mat 3). The activity of 8-hydroxyMatairesinol was lower than that of Matairesinol (Mat 1).
    CONCLUSIONS:
    The superoxide scavenging activity of the oxidized Matairesinols was also demonstrated for the first time. It is assumed that the pKa value of phenol in the oxidized Matairesinols affected this activity.
    In vivo:
    J Ethnopharmacol . 2016 Jul 1;187:49-56.
    Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model[Pubmed: 27085937]
    Abstract Ethnopharmacological relevance: Forsythia suspensa is used in traditional medicine to treat inflammation. To clarify the anti-inflammatory and anti-allergic effects of F. suspensa fruits, we determined the therapeutic effects of crude extract, fractions, and a constituent from F. suspensa fruits on a murine atopic dermatitis (AD) model. Materials and methods: We investigated the inhibitory effects of F. suspensa extract (FSE), extract fractions, and the constituent matairesinol on histamine release from MC/9 mast cells activated by compound 48/80 and the development of AD-like skin lesions and symptoms in NC/Nga mice exposed to Dermatophagoides farinae (mite) extract. High performance liquid chromatography (HPLC) analysis of FSE and its fractions were evaluated using matairesinol standard. Results: FSE, FSE methylene chloride fraction (FSE-MC), and FSE water fraction (FSE-water) inhibited compound 48/80-induced histamine release from MC/9 mast cells. Topical application of FSE or FSE-MC to NC/Nga mice exposed to Dermatophagoides farinae suppressed the development of AD-like skin lesions. Quantitative HPLC analysis of FSE and FSE-MC identified the presence of matairesinol. Topical application of matairesinol to NC/Nga mice effectively reduced AD symptoms, inhibited inflammatory cell infiltration, and lowered immunoglobulin E levels in serum. Further study demonstrated that DfE-induced changes in IL-4 and IFN-γ mRNA expression in the ears of NC/Nga mice were reversed by matairesinol application. Conclusions: These results indicate that the F. suspensa and its constituent matairesinol might be a therapeutic candidate for treating allergic inflammatory disorders such as AD. Keywords: Anti-allergic; Anti-inflammatory; Forsythia suspensa; Histamine; Mast cells; Matairesinol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
    5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
    10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
    50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-罗汉松树脂酚 ; (+)-Matairesinol CFN96715 148409-36-3 C20H22O6 = 358.39 5mg QQ客服:3257982914
    Isosalicifolin; Isosalicifolin CFN96234 156974-99-1 C20H20O6 = 356.4 5mg QQ客服:2159513211
    去甲络石甙元; Nortrachelogenin CFN98454 34444-37-6 C20H22O7 = 374.4 10mg QQ客服:2159513211
    荛花酚 ; (+)-Nortrachelogenin CFN96714 61521-74-2 C20H22O7 = 374.38 5mg QQ客服:2159513211
    (7R)-甲氧基-8-表-罗汉松树脂酚 ; (7R)-Methoxy-8-epi-matairesinol CFN89300 198827-23-5 C21H24O7 = 388.41 5mg QQ客服:215959384
    络石苷元; Trachelogenin CFN90598 34209-69-3 C21H24O7 = 388.15 10mg QQ客服:2056216494
    去甲络石苷; Nortracheloside CFN93080 33464-78-7 C26H32O12 = 536.53 5mg QQ客服:2159513211
    络石苷; Tracheloside CFN90597 33464-71-0 C27H34O12 = 550.2 20mg QQ客服:2056216494
    络石苷元-4'-O-beta-龙胆二糖苷; Trachelogenin 4'-O-beta-gentiobioside CFN95235 106647-13-6 C33H44O17 = 712.7 10mg QQ客服:2056216494
    去甲络石苷元8'-O-β-葡萄糖苷; Nortrachelogenin-8'-O-beta-glucoside CFN95234 858127-38-5 C26H32O12 = 536.5 10mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产