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  • L-赖氨酸

    L-lysine

    L-赖氨酸
    产品编号 CFN94820
    CAS编号 56-87-1
    分子式 = 分子量 C6H14N2O2 = 146.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The cultures from a mutant of Corynebacterium glutamicum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    L-赖氨酸 CFN94820 56-87-1 10mg QQ客服:2159513211
    L-赖氨酸 CFN94820 56-87-1 20mg QQ客服:2159513211
    L-赖氨酸 CFN94820 56-87-1 50mg QQ客服:2159513211
    L-赖氨酸 CFN94820 56-87-1 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2016, 194:219-227
  • Arch Biochem Biophys.2020, 687:108363.
  • Toxicol Rep.2021, 8:1131-1142.
  • Molecules.2017, 22(2)
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Front Mol Neurosci.2023, 15:1083189.
  • J Sci Food Agric.2023, 103(1):213-220.
  • J Nat Med.2020, 74(1):65-75
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • Front Immunol.2020, 11:598556.
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Molecules.2023, 28(3):1313.
  • Pharmaceuticals (Basel).2021, 14(7):633.
  • Pharmaceutics.2023, 15(6):1771.
  • Appl. Sci.2022, 12(4), 2032.
  • BMC Complement Altern Med.2019, 19(1):367
  • Int J Mol Sci.2019, 20(21):E5488
  • ACS Omega.2024, 9(12):14356-14367.
  • Molecules.2020, 25(23):5609.
  • Phytomedicine.2017, 24:77-86
  • J Food Sci Technol.2022, 59(1):212-219.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • ...
  • 生物活性
    Description: Lysine is an essential amino acid for the human body. L-lysine and L-glutamic acid and as useful building blocks for the preparation of bifunctional DTPA-like ligands.
    In vitro:
    Appl Microbiol Biotechnol. 1998 Jan;49(1):24-30.
    Improved L-lysine yield with Corynebacterium glutamicum: use of dapA resulting in increased flux combined with growth limitation.[Pubmed: 9487706]
    The amino acid L-lysine is produced on a large scale using mutants of Corynebacterium glutamicum. However, as yet recombinant DNA techniques have not succeed in improving strains selected for decades by classic mutagenesis for high productivity.
    METHODS AND RESULTS:
    We here report that seven biosynthetic enzymes were assayed and oversynthesis of the dihydrodipicolinate synthase resulted in an increase of lysine accumulation from 220 mM to 270 mM. The synthase, encoded by dapA, is located at the branch point of metabolite distribution to either lysine or threonine and competes with homoserine dehydrogenase for the common substrate aspartate semialdehyde. When graded dapA expression was used, as well as quantification of enzyme activities, intracellular metabolite concentrations and flux rates, a global response of the carbon metabolism to the synthase activity became apparent: the increased flux towards lysine was accompanied by a decreased flux towards threonine. This resulted in a decreased growth rate, but increased intracellular levels of pyruvate-derived valine and alanine.
    CONCLUSIONS:
    Therefore, modulating the flux at the branch point results in an intrinsically introduced growth limitation with increased intracellular precursor supply for lysine synthesis. This does not only achieve an increase in lysine yield but this example of an intracellularly introduced growth limitation is proposed as a new general means of increasing flux for industrial metabolite over-production.
    In vivo:
    BMC Complement Altern Med . 2015 Jun 23;15:193.
    Suppression of acute pancreatitis by L-lysine in mice[Pubmed: 26100532]
    Abstract Background: Acute pancreatitis is an inflammatory disease caused by several factors such as viral infection, drugs, and diagnostic endoscopy. The aim of this study was to evaluate the potential protective or therapeutic effects of L-lysine on pancreatitis induced by L-arginine in mice. Methods: Four groups of mice (10 in each group) were assessed. Group I was the control. Animals in groups II-IV were injected intraperitoneally with L-arginine hydrochloride (400 mg/kg body weight [bw]) for 3 days. Group III animals were orally pre-treated with L-lysine (10 mg/kg bw), whereas group IV animals were orally post-treated with L-lysine (10 mg/kg bw). Serum samples were subjected to amylase, lipase, transaminase, and interleukin-6 (IL-6) assays. The pancreas was excised to measure the levels of malondialdehyde, nitric oxide, catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase. Results: Pre- or post-treatment with L-lysine led to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement was observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (p < 0.001). However, the treatment potential of L-lysine was better as a protective agent than a therapeutic agent. Conclusions: L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity. These effects may involve upregulation of anti-inflammatory factors and subsequent downregulation of IL6.
    Acta Cir Bras . 2017 Apr;32(4):297-306.
    Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine[Pubmed: 28538804]
    Abstract Purpose:: To evaluated the effects of L-lysine on the intestinal and urothelial epithelia in cystoplasty in rats. Methods:: Twenty-eight 9-week-old rats were assigned to 4 groups: Group A (n=8) cystoplasty followed by administration of L-lysine (150 mg/kg body weight by gavage) for 30 weeks; Group B (n=8) cystoplasty + water for 30 weeks; Group C (n=6) L-lysine for 30 weeks; Group D (n=6) water for 30 weeks. Results:: On histopathology with hematoxylin and eosin, mild to moderate hyperplasia transitional was observed in at the site of anastomosis in all animals submitted to cystoplasty (Groups A and B), but "transitional metaplasia" of the intestinal glandular epithelium was more accentuated in Group A (p=0.045). No inflammatory cells, dysplasia or abnormalities were observed. Staining with Alcian blue revealed a substantial reduction of goblet cells and mucins in the colon segment (Groups A and B). Conclusion:: The administration of L-lysine to rats accelerated the development of transitional metaplasia in the epithelium of the colon segment in cystoplasty.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.8399 mL 34.1997 mL 68.3995 mL 136.7989 mL 170.9986 mL
    5 mM 1.368 mL 6.8399 mL 13.6799 mL 27.3598 mL 34.1997 mL
    10 mM 0.684 mL 3.42 mL 6.8399 mL 13.6799 mL 17.0999 mL
    50 mM 0.1368 mL 0.684 mL 1.368 mL 2.736 mL 3.42 mL
    100 mM 0.0684 mL 0.342 mL 0.684 mL 1.368 mL 1.71 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伞形花内酯; 7-羟基香豆素; Umbelliferone CFN97503 93-35-6 C9H6O3 = 162.1 20mg QQ客服:2159513211
    2-羟基-3,4,5,6-四甲氧基查尔酮; 2-Hydroxy-3,4,5,6-tetramethoxychalcone CFN97758 219298-74-5 C19H20O6 = 344.36 5mg QQ客服:1413575084
    天芥菜品碱; Heliosupine CFN00268 32728-78-2 C20H31NO7 = 397.47 5mg QQ客服:1457312923
    Omecamtiv mecarbil (CK-1827452); Omecamtiv mecarbil (CK-1827452) CFN60386 873697-71-3 C20H24FN5O3 = 401.43 5mg QQ客服:1413575084

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