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  • L-蛋氨酸

    L-Methionine

    L-蛋氨酸
    产品编号 CFN70179
    CAS编号 63-68-3
    分子式 = 分子量 C5H11NO2S = 149.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源
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    L-蛋氨酸 CFN70179 63-68-3 10mg QQ客服:2056216494
    L-蛋氨酸 CFN70179 63-68-3 20mg QQ客服:2056216494
    L-蛋氨酸 CFN70179 63-68-3 50mg QQ客服:2056216494
    L-蛋氨酸 CFN70179 63-68-3 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:690113.
  • Sci Rep. 2018, 462(8)
  • J Nat Prod.2022, doi: 10.1021
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Applied Biological Chemistry2023, 66:42.
  • J Pharmaceut Biomed2020, 182:113110
  • Plant J.2021, 107(6):1711-1723.
  • Arch Pharm Res.2015, 38(6):1080-9
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  • Pharmaceutics.2021, 13(7):1028.
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  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Cancers (Basel).2021, 13(9):2223.
  • ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
  • Plant Pathology2022, 10.1111:ppa.13651.
  • Horticulturae2024, 10(4), 382.
  • National Academy Science Letters2023, s40009.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
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  • Int J Mol Sci.2023, 24(23):17118.
  • ACS Pharmacol Transl Sci.2024, 7(2):395-405.
  • Universidade Estadual Paulista2017, 42785
  • ...
  • 生物活性
    Description: L-Methionine is marker of cell viability and estimating proliferative activity. L-Methionine and L-cystine can improve hyperlipidemia by restoring LPL and HSL activities, it also might be a new potential drug for Parkinson's disease treatment.
    Targets: TNF-α
    In vitro:
    Journal of Nuclear Medicine Official Publication Society of Nuclear Medicine, 1995, 36(2):252.
    In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous-cell carcinoma of the head and neck.[Reference: WebLink]
    Estimation of tumor proliferative activity is important for the optimal management of head and neck cancer. Noninvasive metabolic imaging with PET may complement currently used cytopathologic methods to study tumor proliferation.
    METHODS AND RESULTS:
    Fluorodeoxyglucose (FDG) and L-methionine (MET) were studied for their potential to assess in vitro the growth characteristics of three squamous-cell carcinoma (SCC) cell lines established recently in patients with head and neck cancer. A time-course uptake of tritiated FDG and MET was measured over the complete growth cycle of one rapidly growing (UT-SCC-5) and two relatively slower growing (UT-SCC-1A and UT-SCC-9) cell lines. DNA flow cytometry was used for assessment of proliferative activity. There was a strong linear relationship for both FDG and MET uptake versus the viable cell number although absolute MET uptake was consistently lower than that of FDG in the exponential and plateau phases of growth (p < 0.01), leading MET to underestimate cell number. The pattern of MET uptake followed the flow cytometric changes in the proliferation index (% of S + G2/M cells) in two of three cases (UT-SCC-1A and UT-SCC-5) while a similar, although clearly weaker, relationship was seen with FDG and flow cytometry findings in only one case (UT-SCC-5).
    CONCLUSIONS:
    In these three human SCC cell lines assessed in vitro, FDG is a better marker of cell viability than MET, whereas MET is superior for estimating proliferative activity. Extrapolations of these in vitro data to the interpretation of PET images should be made with caution since tumors may have confounding factors that may affect in vivo tracer uptake.
    Cytotechnology, 2010, 62(3):225-233.
    Effects of sulfur amino acids, L-methionine, L-cystine and L-cysteine on lipoprotein lipase and hormone-sensitive lipase in differentiated mouse 3T3-L1 adipocytes.[Reference: WebLink]
    Rats subcutaneously implanted with AH109A hepatoma cells show hyperlipidemia with high concentrations of serum triglyceride and nonesterified fatty acid, suppression of lipoprotein lipase (LPL), and elevation of hormone-sensitive lipase (HSL) activities during the growth of the hepatoma. Supplementation of the diet with sulfur amino acids such as L-methionine (Met) and L-cystine (Cys) improved hyperlipidemia by restoring LPL and HSL activities.
    METHODS AND RESULTS:
    In the present study, we have attempted to examine the effects of sulfur amino acids on the activity and mRNA level of LPL and the activity of HSL using 3T3-L1 cells, which are known to differentiate to adipocytes. The adipocytes were incubated with various concentrations of Met, Cys or L-cysteine (CysH) in the absence or presence of tumor necrosis factor-α (TNF-α). LPL activity was suppressed by TNF-α. In the absence of TNF-α, Met, Cys and CysH did not change the LPL activity. In the presence of TNF-α, Met and Cys significantly increased the LPL activity, and Met also enhanced the LPL mRNA level. HSL activity was also suppressed by TNF-α. In the absence of TNF-α, Met enhanced the HSL activity. In the presence of TNF-α, Met, Cys and CysH suppressed the HSL activity. Sulfur amino acids such as Met, Cys and CysH affected the LPL activity, mRNA level, and HSL activity in 3T3-L1 adipocytes.
    CONCLUSIONS:
    Some of these effects of sulfur amino acids were different between LPL and HSL, between the absence and the presence of TNF-α, and between 3T3-L1 adipocytes and the adipose tissue from rats.
    In vivo:
    Life Sciences, 1983, 32(20):2321-2328.
    A subacute treatment of L-methionine induces an increase in the number of [3H]spiperone binding sites in the striatum of the rat.[Reference: WebLink]

    METHODS AND RESULTS:
    A subacute treatment, 500 mg/kg I.P. twice daily during 5 days, by L-methionine provoked an increase in the B max of [ 3H]-spiperone binding in the striatum of the rat. This increase was associated to a decrease in membrane microviscosity. However in these conditions no changes were found in the [ 3H]-DHA, [ 3H]QNB bindings or in the brain dopamine sensitive adenylate cyclase activity. L-methionine treatment reduced the accumulation of Dopa after NSD 1015 and antagonized the decrease in striatal acetylcholine provoked by haloperidol.
    CONCLUSIONS:
    Thus L-methionine might be a new potential drug for Parkinson's disease treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.7024 mL 33.5121 mL 67.0241 mL 134.0483 mL 167.5603 mL
    5 mM 1.3405 mL 6.7024 mL 13.4048 mL 26.8097 mL 33.5121 mL
    10 mM 0.6702 mL 3.3512 mL 6.7024 mL 13.4048 mL 16.756 mL
    50 mM 0.134 mL 0.6702 mL 1.3405 mL 2.681 mL 3.3512 mL
    100 mM 0.067 mL 0.3351 mL 0.6702 mL 1.3405 mL 1.6756 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
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    Rediocide A; Rediocide A CFN98341 280565-85-7 C44H58O13 = 794.9 5mg QQ客服:2056216494

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