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  • 异贝壳杉烯酸, 贝壳杉烯酸

    Kaurenoic acid

    异贝壳杉烯酸, 贝壳杉烯酸
    产品编号 CFN97703
    CAS编号 6730-83-2
    分子式 = 分子量 C20H30O2 = 302.46
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Diterpenoids
    植物来源 The herbs of Croton antisyphiliticus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异贝壳杉烯酸, 贝壳杉烯酸 CFN97703 6730-83-2 10mg QQ客服:3257982914
    异贝壳杉烯酸, 贝壳杉烯酸 CFN97703 6730-83-2 20mg QQ客服:3257982914
    异贝壳杉烯酸, 贝壳杉烯酸 CFN97703 6730-83-2 50mg QQ客服:3257982914
    异贝壳杉烯酸, 贝壳杉烯酸 CFN97703 6730-83-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max-Planck-Insitut (Germany)
  • Amity University (India)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Complutense University of Madrid (Spain)
  • Siksha O Anusandhan University (India)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Kazusa DNA Research Institute (Japan)
  • Charles Sturt University (Denmark)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Gyeongsang National University (Korea)
  • Yale University (USA)
  • University of the Basque Country (Spain)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JAOCS2021, 98(7):779-794.
  • Biol Pharm Bull.2017, 40(6):797-806
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Cancers (Basel).2023, 15(1):37.
  • Molecules.2019, 24(17):E3127
  • Curr Res Virol Sci.2022, 3:100019.
  • J Control Release.2021, 336:159-168.
  • Int J Mol Sci.2021, 22(12):6466.
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Biomed Pharmacother.2021, 139:111585.
  • Cell Rep.2020, 32(11):108158.
  • J Clin Med.2019, 8(10):E1664
  • Vietnam Journal of Science2022,64(2):69-75.
  • Int J Mol Med.2015, 35(5):1237-45
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Heliyon.2022, 8(12):e12031.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Wageningen University & Research2018, January 2018
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Int J Pharmacol2020, 16:1-9
  • Nutrients.2020, 12(12):3607.
  • Int J Mol Sci.2021, 22(8):4211.
  • ...
  • 生物活性
    Description: Kaurenoic acid has anti-inflammatory, analgesic, antimicrobial, cytotoxic and embryotoxic effects; it exerts a uterine relaxant effect acting principally through calcium blockade and in part, by the opening of ATP-sensitive potassium channels. Kaurenoic acid involves the inhibition of cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
    Targets: NO | PGE | COX | NOS | NF-kB | ATP | GMP
    In vitro:
    Evid Based Complement Alternat Med. 2013;2013:160592.
    Kaurenoic Acid from Aralia continentalis Inhibits Biofilm Formation of Streptococcus mutans.[Pubmed: 23662113]
    We isolated a single chemical compound from A. continentalis and identified it to be kaurenoic acid (KA) and investigated the influence of anticariogenic properties.
    METHODS AND RESULTS:
    Inhibitory effects of KA on cariogenic properties such as growth, acid production, biofilm formation, and the adherence of S. mutans were evaluated. Furthermore, real-time PCR analysis was performed to evaluate the influence of KA on the genetic expression of virulence factors. KA significantly inhibited the growth and acid production of S. mutans at 2-4  μ g/mL and 4  μ g/mL of KA, respectively. Furthermore, the adherence onto S-HAs was inhibited at 3-4  μ g/mL of KA and biofilm formation was significantly inhibited when treated with 3  μ g/mL KA and completely inhibited at 4  μ g/mL. Also, the inhibitory effect of KA on biofilm formation was confirmed by SEM. In confocal laser scanning microscopy, bacterial viability gradually decreased by KA in a dose dependent manner. Real-time PCR analysis showed that the expressions of gtfB, gtfC, gbpB, spaP, brpA, relA, and vicR were significantly decreased in S. mutans when it was treated with KA.
    CONCLUSIONS:
    These results suggest that KA from A. continentalis may be a useful agent for inhibiting the cariogenic properties of S. mutans.
    In vivo:
    Pharmacol Biochem Behav. 2013 Aug;109:38-43.
    Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis.[Pubmed: 23664900]
    The herbal preparations of Annona senegalensis Pers. (Annonaceae) root bark are used in Nigerian ethnomedicine for the treatment of epilepsy and febrile seizures. The scientific evidence for this effect has been reported. The aim of this study was to identify and characterize the active constituent responsible for the anticonvulsant effect.
    METHODS AND RESULTS:
    Bioactive-guided fractionation of the methanol-methylene chloride root bark extract (MME) of A. senegalensis using pentylenetetrazole (PTZ)-induced seizures in mice, afforded a potent anticonvulsant ethyl-acetate fraction (EF). Further fractionation of the EF yielded eight sub-fractions (F₁-F₈) which were tested for anticonvulsant activity. The sub-fraction F₂ yielded white crystals that were purified to obtain A. senegalensis crystals, AS2. The AS2, which exhibited potent anticonvulsant effects, was characterized by 1D and 2D NMR spectroscopy, mass spectroscopy and X-ray crystallography. The AS2 was characterized as kaur-16-en-19-oic acid (KA), a diterpenoid. The AS2 indicated an oral LD₅₀ of 3800 mg/kg. The results showed that the MME, EF and AS2 significantly (P<0.05) and dose-dependently delayed the onset of myoclonic spasms and tonic-clonic phases of seizures induced by PTZ and maximal electroshock seizures (MES).
    CONCLUSIONS:
    Kaurenoic acid was identified as the anticonvulsant principle in the root bark extract of A. senegalensis. The anticonvulsant effect of the MME, EF and AS2 is most likely being mediated through central inhibitory mechanisms.
    Phytomedicine. 2011 Jun 15;18(8-9):677-82.
    Inhibitory effects of kaurenoic acid from Aralia continentalis on LPS-induced inflammatory response in RAW264.7 macrophages.[Pubmed: 21211951]
    This study investigates the anti-inflammatory effects of a diterpenoid, kaurenoic acid, isolated from the root of Aralia continentalis (Araliaceae).
    METHODS AND RESULTS:
    To determine its anti-inflammatory effects, LPS-induced RAW264.7 macrophages were treated with different concentrations of kaurenoic acid and carrageenan-induced paw edema mice model was used in vivo. Kaurenoic acid (ent-kaur-16-en-19-oic acid) dose-dependently inhibited nitric oxide (NO) production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression at micromolar concentrations in LPS-induced RAW264.7 macrophages with IC(50) (the half maximal inhibitory concentration) values of 51.73 (±2.42) μM and 106.09 (±0.27) μM in NO production and PGE(2) release, respectively. Kaurenoic acid also dose-dependently inhibited LPS-induced activation of NF-κB as assayed by electrophorectic mobility shift assay (EMSA) and it almost abolished NF-κB DNA binding affinity at 100μM. Furthermore, the in vivo anti-inflammatory effect of kaurenoic acid was examined in a carrageenan-induced paw edema model. Eight ICR mice in each group were injected with carrageenan and observed hourly, compared with the control group. Kaurenoic acid dose-dependently reduced paw swelling up to 34.4% at 5h after induction, demonstrating inhibition in an acute inflammation model.
    CONCLUSIONS:
    Taken together, our data suggest that kaurenoic acid, a major diterpenoid from the root of A. continentalis shows anti-inflammatory activity and the inhibition of iNOS and COX-2 expression might be one of the mechanisms responsible for its anti-inflammatory properties.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3062 mL 16.5311 mL 33.0622 mL 66.1244 mL 82.6556 mL
    5 mM 0.6612 mL 3.3062 mL 6.6124 mL 13.2249 mL 16.5311 mL
    10 mM 0.3306 mL 1.6531 mL 3.3062 mL 6.6124 mL 8.2656 mL
    50 mM 0.0661 mL 0.3306 mL 0.6612 mL 1.3225 mL 1.6531 mL
    100 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.6612 mL 0.8266 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异贝壳杉烯酸, 贝壳杉烯酸; Kaurenoic acid CFN97703 6730-83-2 C20H30O2 = 302.46 20mg QQ客服:2056216494
    9Beta-羟基-对映贝壳杉-16-烯酸; Pterokaurene L3 CFN97685 77658-38-9 C20H30O3 = 318.46 5mg QQ客服:1413575084
    3Alaph-Tigloyloxypterokaurene L3; 3Alaph-Tigloyloxypterokaurene L3 CFN96481 1588516-87-3 C25H36O5 = 416.56 5mg QQ客服:1413575084
    (4beta,7beta)-7-羟基贝壳杉-16-烯-18-酸; Sventenic acid CFN96012 126778-79-8 C20H30O3 = 318.5 5mg QQ客服:2159513211
    (4BETA,7BETA)-7-(乙酰氧基)-贝壳杉-16-烯-18-酸; Acetylsventenic acid CFN97982 126737-42-6 C22H32O4 = 360.5 5mg QQ客服:2056216494
    3 Beta-巴豆酰基氧基-等效-贝壳杉-16-烯酸; ent-3Beta-Tigloyloxykaur-16-en-19-oic acid CFN97869 79406-09-0 C25H36O4 = 400.6 5mg QQ客服:3257982914
    ent-3beta-羟基贝壳杉-16-烯-19-酸; ent-3beta-Hydroxykaur-16-en-19-oic acid CFN96212 66556-91-0 C20H30O3 = 318.5 5mg QQ客服:3257982914
    对映-3beta-当归酰基氧基-16-贝壳杉-19-烯酸; ent-3Beta-Angeloyloxykaur-16-en-19-oic acid CFN97870 74635-61-3 C25H36O4 = 400.6 5mg QQ客服:2056216494
    3Alpha-当归酰氧基-9beta-羟基等效贝壳杉; 3alpha-Angeloyloxypterokaurene L3 CFN97677 79406-11-4 C25H36O5 = 416.56 5mg QQ客服:3257982914
    对映-3beta-肉桂酰氧基贝壳杉-16-烯-19; ent-3beta-Cinnamoyloxykaur-16-en-19-oic acid CFN97678 79406-10-3 C29H36O4 = 448.60 5mg QQ客服:215959384

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