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  • 刺梨苷 F1

    Kajiichigoside F1

    刺梨苷 F1
    产品编号 CFN90901
    CAS编号 95298-47-8
    分子式 = 分子量 C36H58O10 = 650.84
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Rosa rugosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    刺梨苷 F1 CFN90901 95298-47-8 1mg QQ客服:3257982914
    刺梨苷 F1 CFN90901 95298-47-8 5mg QQ客服:3257982914
    刺梨苷 F1 CFN90901 95298-47-8 10mg QQ客服:3257982914
    刺梨苷 F1 CFN90901 95298-47-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Canterbury (New Zealand)
  • Amity University (India)
  • Shanghai University of TCM (China)
  • Melbourne University (Australia)
  • Texas A&M University (USA)
  • Massachusetts General Hospital (USA)
  • Istanbul University (Turkey)
  • The University of Newcastle (Australia)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Monash University Malaysia (Malaysia)
  • Imperial College London (United Kingdom)
  • National Research Council of Canada (Canada)
  • National Chung Hsing University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Integr Plant Biol.2023, 13564.
  • Food Chem.2017, 221:1135-1144
  • Eur J Pharmacol.2022, 917:174744.
  • Cell.2022, 185(23):4298-4316.e21.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Dent Mater J. 2024, dmj.2023-294.
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Front Immunol.2023, 14:1240800.
  • Molecules.2020, 25(23):5556.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Sci Rep. 2018, 1-9
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Preprints2022, 202211.0388.v1.
  • BMC Complement Altern Med.2014, 14:352
  • J Agric Food Chem.2016, 64(35):6783-90
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • Nutrients.2023, 15(4):950.
  • Nutrients.2020, 12(11):3448.
  • Planta Med.2019, 85(3):217-224
  • Biochem Pharmacol.2020, 178:114083
  • Front Pharmacol.2019, 10:1226
  • J Plant Biotechnol.2023, 50:070-075.
  • ...
  • 生物活性
    Description: Kajiichigoside F1 shows haemolytic and in vitro antiviral activity; it also exhibits in vivo hepatoprotective effects, it can inhibit d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes(IC50=14.1uM). Kajiichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats.
    Targets: Immunology & Inflammation related | Antifection
    In vivo:
    Biol Pharm Bull. 2005 Jan;28(1):101-4.
    19Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa.[Pubmed: 15635171]
    To search for antiinflammtory 19alpha-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated.
    METHODS AND RESULTS:
    The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of Kajiichigoside F1 (1, euscaphic acid 28-O-glucoside) and rosamultin (2, tormentic acid 28-O-glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order: 4>3>2>1.
    CONCLUSIONS:
    These results suggest that 19alpha-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.
    Phytochemistry. 2014 Jun;102:169-81.
    Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.[Pubmed: 24697904]
    A methanol extract from the tuberous roots of Potentilla anserina (Rosaceae) exhibited hepatoprotective effects against d-galactosamine (d-GalN)/lipopolysaccharide-induced liver injuries in mice.
    METHODS AND RESULTS:
    Six triterpene 28-O-monoglucopyranosyl esters, potentillanosides A-F, were isolated from the extract along with 32 known compounds, including 15 triterpenes. The structures of potentillanosides A-F were determined on the basis of spectroscopic properties and chemical evidence. Four ursane-type triterpene 28-O-monoglycosyl esters, potentillanoside A (IC50=46.7μM), 28-O-β-d-glucopyranosyl pomolic acid (IC50=9.5μM), rosamutin (IC50=35.5μM), and Kajiichigoside F1 (IC50=14.1μM), inhibited d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes.
    CONCLUSIONS:
    Among these four triterpenes, potentillanoside A, rosamutin, and kaji-ichigoside F1 exhibited in vivo hepatoprotective effects at doses of 50-100mg/kg, p.o. The mode of action was ascribable to the reduction in cytotoxicity caused by d-GalN.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5365 mL 7.6824 mL 15.3648 mL 30.7295 mL 38.4119 mL
    5 mM 0.3073 mL 1.5365 mL 3.073 mL 6.1459 mL 7.6824 mL
    10 mM 0.1536 mL 0.7682 mL 1.5365 mL 3.073 mL 3.8412 mL
    50 mM 0.0307 mL 0.1536 mL 0.3073 mL 0.6146 mL 0.7682 mL
    100 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3073 mL 0.3841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    藤黄酸; Morellic acid CFN92093 5304-71-2 C33H36O8 = 560.7 20mg QQ客服:1457312923
    6-beta-羟基莨菪碱; 6-beta-Hydroxyhyoscyamine CFN00198 55869-99-3 C17H23NO4 = 305.37 5mg QQ客服:2056216494
    6-Deoxyisojacareubin; 6-Deoxyisojacareubin CFN89446 26486-92-0 C18H14O5 = 310.30 5mg QQ客服:215959384
    Gelomulide B; Gelomulide B CFN96293 122537-60-4 C22H28O6 = 388.5 5mg QQ客服:3257982914

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