麻枫树酚酮B

Jatropholone B

	产品编号	CFN93275
	CAS编号	71386-38-4
	分子式 = 分子量	C₂₀H₂₄O₂ = 296.41
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The branches of Jatropha carcas L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
麻枫树酚酮B	CFN93275	71386-38-4	1mg	QQ客服：1413575084
麻枫树酚酮B	CFN93275	71386-38-4	5mg	QQ客服：1413575084
麻枫树酚酮B	CFN93275	71386-38-4	10mg	QQ客服：1413575084
麻枫树酚酮B	CFN93275	71386-38-4	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Deutsches Krebsforschungszentrum (Germany)

Weizmann Institute of Science (Israel)

The University of Newcastle (Australia)

University of Hawaii Cancer Center (USA)

Shanghai Institute of Biochemistry and Cell Biology (China)

Medical University of Gdansk (Poland)

FORTH-IMBB (Greece)

Instituto Politécnico de Bragan?a (Portugal)

Max Rubner-Institut (MRI) (Germany)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

Seoul National University (Korea)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Harvard University (USA)

University of Wisconsin-Madison (USA)

More...

Description:

Jatropholone B shows antiproliferative activity against cancer cell lines. It also has gastroprotective activity in preventing the gastric lesions in mice.

In vitro:

Planta Med. 2009 Nov;75(14):1520-2.

Antiproliferative activity of the diterpenes jatrophone and jatropholone and their derivatives.[Pubmed: 19562659 ]

The antiproliferative activity of the diterpenes jatropholone A and B, 16 semi-synthetic derivatives thereof, and that of jatrophone and its three derivatives was assessed on human cell cultures.
METHODS AND RESULTS:
The cells used comprised normal lung fibroblasts (MRC-5), gastric adenocarcinoma (AGS), leukemia (HL-60), lung cancer (SK-MES-1), and bladder carcinoma (J82). Jatropholone A ( 1) was inactive against all the tumor cell lines; however, its acetylation rendered a compound with antiproliferative activity. The epimeric Jatropholone B ( 8) was active against all the cancer cell lines, and its derivatives presented different effects on the selected cell lines.
CONCLUSIONS:
While jatrophone ( 19) showed strong anticancer activity, its derivatives 9beta,13alpha-dihydroxyisabellione and 13alpha-hydroxy-9 beta-acetoxyisabellione were less active.

In vivo:

Planta Med. 2007 Aug;73(10):1095-100.

Gastroprotective effect and cytotoxicity of semisynthetic jatropholone derivatives.[Pubmed: 17691058]

The gastroprotective effect of the diterpenes jatropholone A, Jatropholone B and 16 semisynthetic derivatives was assessed in the HCl/ethanol-induced gastric lesion model in mice and the cytotoxicity was determined towards fibroblasts and AGS cells.
METHODS AND RESULTS:
In a dose-response study, Jatropholone B reduced gastric lesions by 65% at 6 mg/kg and jatropholone A by 54% at 100 mg/kg. The Jatropholone B derivatives 9 - 14 and the compounds 15 - 18 were compared at a single oral dose of 25 mg/kg while the jatropholone A derivatives 2 - 7 were assessed at 100 mg/kg. A decrease in gastroprotective activity was observed for the ether as well as for the ester derivatives of Jatropholone B. The methyl and propyl ethers of jatropholone A were more gastroprotective than the natural product. The placement of an additional methyl group at C-2 in the Jatropholone B derivatives led to a loss of selectivity, the methyl and propyl ethers lack a gastroprotective effect. Jatropholone B was not toxic towards AGS cells and fibroblasts. Jatropholone A was active only against AGS cells. The gastroprotective effect of the epimeric jatropholones was selective showing a higher effect for Jatropholone B.
CONCLUSIONS:
These results further support that the stereochemistry of the methyl group at C-2 in the jatropholones plays a relevant role in preventing the gastric lesions in mice. The compounds 3, 5 - 7, 10 and 12 - 18 are described for the first time.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3737 mL	16.8685 mL	33.7371 mL	67.4741 mL	84.3426 mL
5 mM	0.6747 mL	3.3737 mL	6.7474 mL	13.4948 mL	16.8685 mL
10 mM	0.3374 mL	1.6869 mL	3.3737 mL	6.7474 mL	8.4343 mL
50 mM	0.0675 mL	0.3374 mL	0.6747 mL	1.3495 mL	1.6869 mL
100 mM	0.0337 mL	0.1687 mL	0.3374 mL	0.6747 mL	0.8434 mL

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甲基 3-O-阿魏酰奎尼酸酯; Methyl 3-O-feruloylquinate	CFN92446	154418-15-2	C₁₈H₂₂O₉ = 382.4	5mg	QQ客服：2056216494
葫芦素D; Cucurbitacin D	CFN90209	3877-86-9	C₃₀H₄₄O₇ = 516.67	10mg	QQ客服：2159513211
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麻枫树酚酮B

Jatropholone B

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