Info: Read More
  • 中药标准品生产商,产品定制服务
  • 依伐卡托

    Ivacaftor (VX-770)

    依伐卡托
    产品编号 CFN60053
    CAS编号 873054-44-5
    分子式 = 分子量 C24H28N2O3 = 392.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    依伐卡托 CFN60053 873054-44-5 1mg QQ客服:2159513211
    依伐卡托 CFN60053 873054-44-5 5mg QQ客服:2159513211
    依伐卡托 CFN60053 873054-44-5 10mg QQ客服:2159513211
    依伐卡托 CFN60053 873054-44-5 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wisconsin-Madison (USA)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Universidad de La Salle (Mexico)
  • Worcester Polytechnic Institute (USA)
  • University of Otago (New Zealand)
  • University of Eastern Finland (Finland)
  • Mahatma Gandhi University (India)
  • Universiti Sains Malaysia (Malaysia)
  • National Cancer Institute (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Amsterdam (Netherlands)
  • Macau University of Science and Technology (China)
  • Universidad de Antioquia (Colombia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Histol Histopathol.2022, 18518.
  • J Med Chem.2023, 66(6):4106-4130.
  • J Pharm Anal.2016, 6(6):363-373
  • Nutrients.2018, 10(12):E1998
  • Neurochem Int.2018, 121:114-124
  • Heliyon.2024, 10(7):e28364.
  • BMC Complement Altern Med.2019, 19(1):11
  • J Ethnopharmacol.2022, 282:114574.
  • Appl. Sci.2020, 10(23), 8729
  • Horticulture Research2020, 7:111.
  • Inflammation.2022, 45(6):2529-2543.
  • J Mol Recognit.2020, 33(2):e2819
  • J Biotechnol.2020, 318:10-19.
  • Kyung Hee University2024, rs-3888374
  • Appl. Sci. 2021, 11(17),7829
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Plant Physiol Biochem.2023, 203:108073.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Journal of Cluster Science2024, 35:635-656.
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • Separations2023, 10(7), 411.
  • Molecules.2017, 22(6)
  • J of Essential Oil Research2019, 1677272
  • ...
  • 生物活性
    Description: Ivacaftor (VX-770) is a selective potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM in fisher rat thyroid cells, respectively.
    In vitro:
    Proc Natl Acad Sci U S A,2009 Nov 3;106(44):18825-30.
    Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.[Pubmed: 19846789]
    Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated epithelial anion channel involved in salt and fluid transport in multiple organs, including the lung. Most CF mutations either reduce the number of CFTR channels at the cell surface (e.g., synthesis or processing mutations) or impair channel function (e.g., gating or conductance mutations) or both. There are currently no approved therapies that target CFTR.
    METHODS AND RESULTS:
    Here we describe the in vitro pharmacology of VX-770, an orally bioavailable CFTR potentiator in clinical development for the treatment of CF. In recombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. VX-770 also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. Furthermore, VX-770 reduced excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures.
    CONCLUSIONS:
    These results support the hypothesis that pharmacological agents that restore or increase CFTR function can rescue epithelial cell function in human CF airway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5478 mL 12.7392 mL 25.4784 mL 50.9567 mL 63.6959 mL
    5 mM 0.5096 mL 2.5478 mL 5.0957 mL 10.1913 mL 12.7392 mL
    10 mM 0.2548 mL 1.2739 mL 2.5478 mL 5.0957 mL 6.3696 mL
    50 mM 0.051 mL 0.2548 mL 0.5096 mL 1.0191 mL 1.2739 mL
    100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5096 mL 0.637 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    磷酸二甲氨乙酯; Demanyl phosphate CFN00071 6909-62-2 C4H12NO4P = 169.12 5mg QQ客服:3257982914
    无羁萜,木栓酮; Friedelin CFN98936 559-74-0 C30H50O = 426.7 10mg QQ客服:3257982914
    PF-04217903; PF-04217903 CFN60403 956905-27-4 C19H16N8O = 372.38 5mg QQ客服:1413575084
    Taberdivarine H ; Taberdivarine H CFN96650 1662688-34-7 C20H22N2O2 = 322.41 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产