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  • 异甘草黄酮醇

    Isolicoflavonol

    异甘草黄酮醇
    产品编号 CFN97594
    CAS编号 94805-83-1
    分子式 = 分子量 C20H18O6 = 354.36
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Broussonetia kazinoki Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异甘草黄酮醇 CFN97594 94805-83-1 1mg QQ客服:2056216494
    异甘草黄酮醇 CFN97594 94805-83-1 5mg QQ客服:2056216494
    异甘草黄酮醇 CFN97594 94805-83-1 10mg QQ客服:2056216494
    异甘草黄酮醇 CFN97594 94805-83-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • University of Madras (India)
  • Charles University in Prague (Czech Republic)
  • Universitas Airlangga (Indonesia)
  • Medizinische Universit?t Wien (Austria)
  • Universitas islam negeri Jakarta (Indonesia)
  • Uniwersytet Gdański (Poland)
  • University of the Basque Country (Spain)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universidade de Franca (Brazil)
  • University of Melbourne (Australia)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Max-Planck-Insitut (Germany)
  • Wroclaw Medical University (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Apicultural Research2020, 10.1080
  • Food Funct.2021, 12(13):5892-5902.
  • Phytomedicine.2022, 102:154183.
  • JEJU National University2022, 10478.
  • J Ethnopharmacol.2019, 244:112074
  • Biomed Pharmacother.2022, 156:113929.
  • Molecules.2022, 27(5):1675
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J of Ana. Chem.2019, 74(11):1113-1121
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Molecules.2016, 21(6)
  • Univerzita Karlova2022, 228192.
  • Environ Toxicol.2023, 38(7):1641-1650.
  • Phytomedicine.2016, 23(4):331-9
  • Front Pharmacol.2021, 12:770667.
  • Chemistry of Natural Compounds2018, 204-206
  • Korean J of Crop Science2019, 452-458
  • Pathogens.2018, 7(3):E62
  • Foods2023, 12(23), 4342.
  • Dent Mater J. 2024, dmj.2023-294.
  • Foods.2021, 10(12):2929.
  • BMC Complement Altern Med.2014, 14:352
  • ...
  • 生物活性
    Description: Isolicoflavonol is a potential cancer chemopreventive agent.
    In vitro:
    Planta Med. 2004 Aug;70(8):691-705.
    Natural inhibitors of carcinogenesis.[Pubmed: 15326546 ]
    Previous collaborative work by our group has led to the discovery of several plant isolates and derivatives with activities in in vivo models of cancer chemoprevention, including deguelin, resveratrol, bruceantin, brassinin, 4'-bromoflavone, and oxomate.
    METHODS AND RESULTS:
    Using a panel of in vitro bioassays to monitor chromatographic fractionation, a diverse group of plant secondary metabolites has been identified as potential cancer chemopreventive agents from mainly edible plants. Nearly 50 new compounds have been isolated as bioactive principles in one or more in vitro bioassays in work performed over the last five years. Included among these new active compounds are alkaloids, flavonoids, stilbenoids, and withanolides, as well as a novel stilbenolignan and the first representatives of the norwithanolides, which have a 27-carbon atom skeleton. In addition, over 100 active compounds of previously known structure have been obtained. Based on this large pool of potential cancer chemopreventive compounds, structure-activity relationships are discussed in terms of the quinone reductase induction ability of flavonoids and withanolides and the cyclooxygenase-1 and -2 inhibitory activities of flavanones, flavones and stilbenoids. Several of the bioactive compounds were found to be active when evaluated in a mouse mammary organ culture assay, when used as a secondary discriminator in our work.
    CONCLUSIONS:
    The compounds (2 S)-abyssinone II, (2 S)-2',4'-dihydroxy-2"-(1-hydroxy-1-methylethyl)dihydrofuro[2,3- h]-flavanone, 3'-[gamma-hydroxymethyl-( E)-gamma-methylallyl]-2,4,2',4'-tetrahydroxychalcone 11'- O-coumarate, isolicoflavonol, isoliquiritigenin, and ixocarpalactone A are regarded as promising leads as potential cancer chemopreventive agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.822 mL 14.1099 mL 28.2199 mL 56.4398 mL 70.5497 mL
    5 mM 0.5644 mL 2.822 mL 5.644 mL 11.288 mL 14.1099 mL
    10 mM 0.2822 mL 1.411 mL 2.822 mL 5.644 mL 7.055 mL
    50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.1288 mL 1.411 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5644 mL 0.7055 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草黄酮醇A; Glycyrrhiza flavonol A CFN91979 197304-01-1 C20H18O7 = 370.35 5mg QQ客服:3257982914
    车桑子素 I; Dodoviscin I CFN96015 1372527-40-6 C21H22O7 = 386.4 5mg QQ客服:2056216494
    Aliarin; Aliarin CFN96008 84294-77-9 C22H24O8 = 416.4 5mg QQ客服:1413575084
    5,7-二羟基-2-[4-羟基-3-(3-甲基-2-丁烯-1-基)苯基]-3,6-二甲氧基-4H-1-苯并吡喃-4-酮; 5,7,4-Trihydroxy-3,6-dimethoxy-3-prenylflavone CFN97995 959421-20-6 C22H22O7 = 398.4 5mg QQ客服:215959384
    Dodovisone D ; Dodovisone D CFN96560 1616683-53-4 C22H22O8 = 414.41 5mg QQ客服:215959384
    Dodovisone A; Dodovisone A CFN96526 1616683-50-1 C27H30O8 = 482.53 5mg QQ客服:2056216494
    Dodovisone B; Dodovisone B CFN96556 1616683-51-2 C27H32O9 = 500.54 5mg QQ客服:1413575084
    Dodovisone C; Dodovisone C CFN96561 1616683-52-3 C27H30O8 = 482.53 5mg QQ客服:2159513211
    Dodonaflavonol; Dodonaflavonol CFN96551 1392213-93-2 C28H32O9 = 512.56 5mg QQ客服:1457312923
    车桑子素 J; Dodoviscin J CFN96035 1372527-42-8 C22H22O7 = 398.4 5mg QQ客服:3257982914

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