异戈米辛O
Isogomisin O
|
|
产品编号 |
CFN97333 |
| CAS编号 |
83916-76-1 |
| 分子式 = 分子量 |
C23H28O7 = 416.5 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Lignans |
| 植物来源 |
The seeds of Schisandra chinensis (Turcz.) Baill. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 异戈米辛O |
CFN97333 |
83916-76-1 |
1mg |
QQ客服：3257982914 |
| 异戈米辛O |
CFN97333 |
83916-76-1 |
5mg |
QQ客服：3257982914 |
| 异戈米辛O |
CFN97333 |
83916-76-1 |
10mg |
QQ客服：3257982914 |
| 异戈米辛O |
CFN97333 |
83916-76-1 |
20mg |
QQ客服：3257982914 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Anna University (India)
Universidade Federal de Goias (UFG) (Brazil)
Kazusa DNA Research Institute (Japan)
Vin?a Institute of Nuclear Sciences (Serbia)
Wroclaw Medical University (Poland)
Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
Cornell University (USA)
Ain Shams University (Egypt)
Cancer Research Initatives Foundation(CARIF) (Malaysia)
Sanford Burnham Medical Research Institute (USA)
Texas A&M University (USA)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
Universidad Veracuzana (Mexico)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Phytomedicine.2019, 56:48-56
Journal of functional foods2018, 171-182
Phytomedicine.2019, 65:153089
Processes2021, 9(1), 153.
Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
Agriculture2022, 12(2),227.
Int J Pharm.2022, 618:121636.
J Ethnopharmacol.2022, 291:115159.
| Description: |
Standard reference |
| In vitro: |
| Planta Med. 2007 Aug;73(10):1116-26. | | Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis.[Pubmed: 17611932] | Plants of the Schisandraceae family contain a variety of pharmacologically active lignans like schizandrin, deoxyschizandrin, deangeloylgomisin B, gomisin A, gomisin O, gamma-schizandrin and isogomisin O.
METHODS AND RESULTS:
Here we have compared the composition of different polar and non-polar extracts of Schisandra sphenanthera and Schisandra chinensis. We also have screened the extracts for antiproliferative and anti-inflammatory effects in different cell-based and cell-free assays. Extracts produced with the non-polar solvents CO(2), hexane and CO(2)/5% ethanol had a similar composition. In contrast, polar extraction with ethanol provided a considerably higher yield, but a lower content of volatiles and lignans in comparison to the non-polar extracts. The proliferation of the epidermal cell lines HaCaT and A431 was dose-dependently inhibited by both the Schisandra sphenanthera and Schisandra chinensis extracts, the non-polar extracts being superior to the polar ones. The non-polar Schisandra sphenanthera extract was the most active with a half-maximal inhibitory concentration of 20 microg/mL. In a cell-free enzyme inhibition assay with recombinant cyclooxygenase-2 (COX-2) the non-polar Schisandra sphenanthera extract dose-dependently inhibited COX-2 catalysed prostaglandin (PG) production (IC(50) = 0.2 microg/mL). It also reduced the ultraviolet-B (UVB)-induced PGE (2) production (IC(50) = 4 microg/mL) and COX-2 expression in HaCaT keratinocytes.
CONCLUSIONS:
We conclude that non-polar SChisandra extracts obtained by CO(2) extraction might be useful in the prevention and treatment of hyperproliferative and inflammatory skin diseases. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.401 mL |
12.0048 mL |
24.0096 mL |
48.0192 mL |
60.024 mL |
| 5 mM |
0.4802 mL |
2.401 mL |
4.8019 mL |
9.6038 mL |
12.0048 mL |
| 10 mM |
0.2401 mL |
1.2005 mL |
2.401 mL |
4.8019 mL |
6.0024 mL |
| 50 mM |
0.048 mL |
0.2401 mL |
0.4802 mL |
0.9604 mL |
1.2005 mL |
| 100 mM |
0.024 mL |
0.12 mL |
0.2401 mL |
0.4802 mL |
0.6002 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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