Isoaltenuene

	产品编号	CFN89012
	CAS编号	126671-80-5
	分子式 = 分子量	C₁₅H₁₆O₆ = 292.28
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The solid cultures of the fungus Colletotrichum sp.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Isoaltenuene	CFN89012	126671-80-5	1mg	QQ客服：1413575084
Isoaltenuene	CFN89012	126671-80-5	5mg	QQ客服：1413575084
Isoaltenuene	CFN89012	126671-80-5	10mg	QQ客服：1413575084
Isoaltenuene	CFN89012	126671-80-5	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sant Gadge Baba Amravati University (India)

The Australian National University (Australia)

University of Eastern Finland (Finland)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

University of Padjajaran (Indonesia)

Anna University (India)

Washington State University (USA)

University of Toronto (Canada)

Melbourne University (Australia)

Georgia Institute of Technology (USA)

University of the Basque Country (Spain)

University of Indonesia (Indonesia)

University of Hawaii Cancer Center (USA)

Guangzhou Institutes of Biomedicine and Health (China)

More...

Description:

Isoaltenuene shows antibiotic activity against Gram-positive bacteria; it also shows a minor phytotoxic activity on tomato leaves at level of 20 ug/spot . Isoaltenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1.

Targets:

Antifection

In vitro:

Yao Xue Xue Bao. 2013 Jun;48(6):891-5.

A new sesquiterpenoid from fungus Colletotrichum sp. and its cytotoxicity.[Pubmed: 23984524]

METHODS AND RESULTS:
A novel sesquiterpenoid (1) and three known compounds identified as Isoaltenuene (2), altenuene (3), and alternariol 4, 10-O-dimethyl ether (4), were isolated in our investigation of the cytotoxic constituents from solid cultures of the endophytic fungus Colletotrichum sp. The structures of these compounds were elucidated through spectroscopic data analysis.
CONCLUSIONS:
All compounds exhibited cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1. Compound 4 could induce the PANC-1 cells inflation or death, but couldn't induce apoptosis at the IC50 of 60.2 microg x mL(-1).

Mycotoxin Res. 1989 Sep;5(2):69-76.

Isolation and structure elucidation of isoaltenuene, a new metabolite ofAlternaria alternata.[Pubmed: 23605299 ]

Isoaltenuene, a previously unknownAlternaria metabolite has been isolated from a rice culture ofAlternaria alternata and purified by semipreparative HPLC.
METHODS AND RESULTS:
The assigned structure, elucidated by UV, IR, MS, and NMR spectroscopy, was 2', 3', 4', 5'-tetrahydro-3, 4'β, 5'α-trihydroxy-5-methoxy-2'α-methyldibenzo (α)-pyrone and corresponded to a diasteroisomer of altenuene with inverted configuration at C-2'.
CONCLUSIONS:
Isoaltenuene showed a minor phytotoxic activity on tomato leaves at level of 20 μg/spot and no antifungal activity onGeotrichum candidum (up to 20 μg/disk).

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4214 mL	17.1069 mL	34.2138 mL	68.4275 mL	85.5344 mL
5 mM	0.6843 mL	3.4214 mL	6.8428 mL	13.6855 mL	17.1069 mL
10 mM	0.3421 mL	1.7107 mL	3.4214 mL	6.8428 mL	8.5534 mL
50 mM	0.0684 mL	0.3421 mL	0.6843 mL	1.3686 mL	1.7107 mL
100 mM	0.0342 mL	0.1711 mL	0.3421 mL	0.6843 mL	0.8553 mL

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