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  • 毛冬青皂苷B2

    Ilexsaponin B2

    毛冬青皂苷B2
    产品编号 CFN93153
    CAS编号 108906-69-0
    分子式 = 分子量 C47H76O17 = 913.10
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Ilex pubescens Hook. et Arn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    毛冬青皂苷B2 CFN93153 108906-69-0 1mg QQ客服:1457312923
    毛冬青皂苷B2 CFN93153 108906-69-0 5mg QQ客服:1457312923
    毛冬青皂苷B2 CFN93153 108906-69-0 10mg QQ客服:1457312923
    毛冬青皂苷B2 CFN93153 108906-69-0 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bonn (Germany)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Universiti Sains Malaysia (Malaysia)
  • Colorado State University (USA)
  • John Innes Centre (United Kingdom)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Illinois (USA)
  • Chiang Mai University (Thailand)
  • Hamdard University (India)
  • Georgia Institute of Technology (USA)
  • University Medical Center Mainz (Germany)
  • Washington State University (USA)
  • University of Toronto (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals (Basel).2024, 17(3):352.
  • Life Sci.2022, 298:120488.
  • Pharmaceutics.2022, 14(3):564.
  • Food Chem.2017, 221:1135-1144
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Molecules.2018, 23(12):E3103
  • Pharmaceutics.2020, 12(9):845.
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Mol Cell.2017, 68(4):673-685
  • Int J Mol Sci.2022, 23(11):6172.
  • Molecules.2021, 26(9):2526.
  • Biomedicines.2022, 10(3):583.
  • Int J Mol Sci.2023, 24(8):7045.
  • Korea Food Research Institute2024, 4798082
  • Cells.2021, 10(10):2633.
  • Phytother Res.2019, 33(7):1784-1793
  • Plant Physiol Biochem.2021, 160:166-174.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Phytomedicine.2019, 61:152813
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • ...
  • 生物活性
    Description: Ilexsaponin B2 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, it is active against PDEI and PDE5A dose-dependently in vitro.
    Targets: PDE | P-gp | cAMP
    In vivo:
    Molecules. 2017 Nov 1;22(11). pii: E1867.
    Study of Absorption Characteristics of the Total Saponins from Radix Ilicis Pubescentis in an In Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC).[Pubmed: 29104273 ]
    In contrast to the extensively reported therapeutic activities, far less attention has been paid to the intestinal absorption of the total saponins from Radix Ilicis Pubescentis (in Chinese Mao-Dong-Qing, MDQ). This study aimed to investigate the intestinal absorption characteristics of ilexgenin A (C1), ilexsaponin A1 (C2), ilexsaponin B1 (C3), Ilexsaponin B2 (C4), ilexsaponin B3 (DC1), and ilexoside O (DC2) when administrated with the total saponins from MDQ (MDQ-TS).
    METHODS AND RESULTS:
    An UPLC method for simultaneous determination of C1, C2, C3, C4, DC1, and DC2 in intestinal outflow perfusate was developed and validated. The absorption characteristics of MDQ-TS were investigated by evaluating the effects of intestinal segments, drug concentration, P-glycoprotein (P-gp) inhibitor (verapomil), endocytosis inhibitor (amantadine) and ethylene diamine tetraacetic acid (EDTA, tight junction modulator) on the intestinal transportation of MDQ-TS by using a single-pass intestinal perfusion (SPIP) rat model, and the influence of co-existing components on the intestinal transport of the six saponins was discussed. The results showed that effective apparent permeability (Papp) of C1, C2, C3, C4, and DC2 administrated in MDQ-TS form had no segment-dependent changes at low and middle dosage levels. C1, C2, C3, D4, DC1, and DC2 administrated in MDQ-TS form all exhibited excellent transmembrane permeability with Papp > 0.12 × 10-2 cm·min-1. Meanwhile, Papp and effective absorption rate constant (Ka) values for the most saponins showed concentration dependence and saturation characteristics. After combining with P-gp inhibitor of verapamil, Papp of C2, C3, and DC1 in MDQ-TS group was significantly increased up to about 2.3-fold, 1.4-fold, and 3.4-fold, respectively in comparison to that of non-verapamil added group. Verapamil was found to improve the absorption of C2, C3, and DC1, indicating the involvement of an active transport mechanism in the absorption process. Compared with the non-amantadine added group, the absorption of C1, C2, C4, DC1, and DC2 were decreased by 40%, 71%, 31%, 53%, and 100%, respectively. Papp for the six target compounds increased up to about 1.2-2.1-fold in comparison with the non-EDTA added, respectively. The gastrointestinal transport of MDQ-TS could be greatly promoted by EDTA, and inhibited by amantadine, implying that the intestinal absorption of MDQ-TS was by passive diffusion and endocytosis process. Compared with monomer administration group, the intestinal absorption of C3, C4, DC1, and DC2 was significantly improved by co-existing components in MDQ-TS, and the non-absorbable saponins of C4, DC1, and DC2 unexpectedly showed sufficient intestinal permeability with Papp > 0.12 × 10-2 cm·min-1.
    CONCLUSIONS:
    This suggested that compounds orally administrated in TCM extract forms displayed unique intestinal absorption characteristics different from those of monomers, and the enhancing intestinal absorption of MDQ-TS reflected a holistic and specific view of traditional Chinese medicines (TCMs).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0952 mL 5.4759 mL 10.9517 mL 21.9034 mL 27.3793 mL
    5 mM 0.219 mL 1.0952 mL 2.1903 mL 4.3807 mL 5.4759 mL
    10 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.1903 mL 2.7379 mL
    50 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4381 mL 0.5476 mL
    100 mM 0.011 mL 0.0548 mL 0.1095 mL 0.219 mL 0.2738 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    橐吾香附酮醇; Ligucyperonol CFN96346 105108-20-1 C15H22O2 = 234.3 5mg QQ客服:2056216494
    threo-6'-Hydroxyustusolate C; threo-6'-Hydroxyustusolate C CFN96621 1175543-07-3 C23H32O7 = 420.50 5mg QQ客服:1457312923
    (1S)-(+)-3-蒈烯; (+)-D-3-Carene CFN70126 498-15-7 C10H16 = 136.2 20mg QQ客服:215959384
    桃金娘烯醇; (-)-Myrtenol CFN70079 19894-97-4 C10H16O = 152.2 20mg QQ客服:3257982914

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