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  • 愈创奥

    Guaiazulene

    愈创奥
    产品编号 CFN93064
    CAS编号 489-84-9
    分子式 = 分子量 C15H18 = 198.30
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 From Euplexaura erecta.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    愈创奥 CFN93064 489-84-9 10mg QQ客服:1457312923
    愈创奥 CFN93064 489-84-9 20mg QQ客服:1457312923
    愈创奥 CFN93064 489-84-9 50mg QQ客服:1457312923
    愈创奥 CFN93064 489-84-9 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • John Innes Centre (United Kingdom)
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  • Auburn University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2021, 10(6):1192.
  • The Korea Journal of Herbology2019, 34(2):25-32
  • J Cell Biochem.2024, 125(4):e30537.
  • Chem Biol Interact.2024, 394:110995.
  • Planta Med.2016, 82(13):1208-16
  • VNU J Science: Med.&Pharm. Sci.2023, 39(2):43-52.
  • Biomol Ther (Seoul).2019, 10.4062
  • Food Chem X.2024, 21:101127.
  • Phytomedicine.2023, 116:154841.
  • Toxins (Basel).2021, 13(12):898.
  • Naunyn Schmiedebergs Arch Pharmacol.2024, 03148-x.
  • Environ Toxicol.2024, 39(5):2927-2936.
  • Int Immunopharmacol. 2020, 83:106403.
  • Microb Pathog.2019, 131:128-134
  • Inflammation.2022, 45(6):2529-2543.
  • International. J. of Food Properties 2017, 20:S131-S140
  • Molecules.2022, 27(19):6681.
  • Indian Journal of Science and Technology2023, 16(SP1):48-56.
  • Environ Toxicol.2023, 38(5):1174-1184.
  • J Colloid Interface Sci.2024, 662:760-773.
  • Agriculture2022, 12(12), 2173.
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  • Plants (Basel).2021, 10(7):1376.
  • ...
  • 生物活性
    Description: Guaiazulene has antioxidant activity, it shows significant protection against paracetamol-induced GSH depletion and hepatic damage. Guaiazulene shows cytotoxic activity on gingival fibroblasts, it has anti-proliferative activity suppressing the proliferation of neuron and N2a-NB cells at high doses. Guaiazulene has in vitro antimicrobial activity against Mycoplasma hominis clinical isolates.
    Targets: Antifection
    In vitro:
    Toxicol In Vitro. 2011 Feb;25(1):64-72.
    Cytotoxic activity of guaiazulene on gingival fibroblasts and the influence of light exposure on guaiazulene-induced cell death.[Pubmed: 20854889 ]
    Guaiazulene (GA) is widely used as a natural ingredient in many health care products and solutions. Although it has been reported to have interesting biological effects, GA and azulene derivatives have been proven to be cytotoxic against normal human cells and human tumor cells; moreover, Guaiazulene has shown photomutagenic properties on bacterial strains.
    METHODS AND RESULTS:
    Therefore, we evaluated and compared the cytotoxicity of GA at different concentrations on human gingival fibroblast (HGF) cell cultures under normal conditions and under UV irradiation (UV-A dose: 6.4 J/cm(2)). The compound tested was found to significantly reduce cell viability (dose-dependent trend, IC(50) 72.1 μM), decrease protein procollagen α1 type I synthesis, a marker for HGF protein, and COL1A1 mRNA expression. The cytotoxic effects were accompanied by activation of an intrinsic apoptotic pathway, studied using transmission electron microscopy (TEM) and caspase-3 activation.
    CONCLUSIONS:
    The light exposure of the cell culture treated decreased GA-induced cell death (IC(50) 128.9 μM), suggesting a photoprotective effect due to the photodegradation of the toxic agent, Guaiazulene. Furthermore, the products of the photodegradation reaction of GA proved not to be toxic against HGFs.
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014 Jun;158(2):208-11.
    In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates.[Pubmed: 23128812]
    The aim of this study was to evaluate the antimicrobial effects of five natural substances against 50 clinical isolates of Mycoplasma hominis.
    METHODS AND RESULTS:
    The in vitro activity of selected natural compounds, cinnamon bark oil, anethole, carvacrol, eugenol and Guaiazulene, was investigated against 50 M. hominis isolates cultivated from cervical swabs by the broth dilution method. All showed valuable antimicrobial activity against the tested isolates. Oil from the bark of Cinnamomum zeylanicum (MBC90 = 500 μg/mL) however was found to be the most effective. Carvacrol (MBC90 = 600 μg/mL) and eugenol (MBC90 = 1000 μg/mL) also possessed strong antimycoplasmal activity.
    CONCLUSIONS:
    The results indicate that cinnamon bark oil, carvacrol and eugenol have strong antimycoplasmal activity and the potential for use as antimicrobial agents in the treatment of mycoplasmal infections.
    In vivo:
    J Pharm Pharmacol. 1997 Sep;49(9):938-42.
    Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats.[Pubmed: 9306266]
    The effect of Guaiazulene, a lipophilic azulene derivative widely found in nature, on radical-mediated processes is examined. The ability of guaizulene to inhibit rat hepatic microsomal membrane lipid peroxidation and to scavenge hydroxyl radicals, as well as to interact with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), was estimated.
    METHODS AND RESULTS:
    It was found that Guaiazulene can inhibit lipid peroxidation very significantly, having an IC50 value of 9.8 microM. It can also scavenge hydroxyl radicals and interact with DPPH. The protection afforded by Guaiazulene to rats with paracetamol-induced liver injury was also investigated. Paracetamol hepatotoxicity is caused by the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which causes oxidative stress and glutathione (GSH) depletion. Hepatic cytosolic protein, GSH, glutathione transferase and glutathione reductase levels are determined as indices of hepatic injury with or without the administration of Guaiazulene. It was found that all parameters affected by paracetamol are restored to normal by Guaiazulene treatment, while the administration of Guaiazulene alone has no effect on the performed tests compared with the control values.
    CONCLUSIONS:
    It was concluded that the significant protection against paracetamol-induced GSH depletion and hepatic damage afforded by Guaiazulene is probably connected with its antioxidant activity. A molecular mechanism of action of Guaiazulene is suggested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0429 mL 25.2143 mL 50.4286 mL 100.8573 mL 126.0716 mL
    5 mM 1.0086 mL 5.0429 mL 10.0857 mL 20.1715 mL 25.2143 mL
    10 mM 0.5043 mL 2.5214 mL 5.0429 mL 10.0857 mL 12.6072 mL
    50 mM 0.1009 mL 0.5043 mL 1.0086 mL 2.0171 mL 2.5214 mL
    100 mM 0.0504 mL 0.2521 mL 0.5043 mL 1.0086 mL 1.2607 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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    3,4-二羟基肉桂酰胺; 3,4-Dihydroxycinnamamide CFN99316 1202-41-1 C9H9NO3 = 179.2 5mg QQ客服:2159513211

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