甘氨酸
Glycine
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 甘氨酸 |
CFN70144 |
56-40-6 |
10mg |
QQ客服：2056216494 |
| 甘氨酸 |
CFN70144 |
56-40-6 |
20mg |
QQ客服：2056216494 |
| 甘氨酸 |
CFN70144 |
56-40-6 |
50mg |
QQ客服：2056216494 |
| 甘氨酸 |
CFN70144 |
56-40-6 |
100mg |
QQ客服：2056216494 |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
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Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor. |
| Targets: |
NMDA |
| In vitro: |
| Nature,1987 Feb 5-11;325(6104):529-31. | | Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink] | Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
METHODS AND RESULTS:
We report here that this response exhibits another remarkable property: it is dramatically potentiated by glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive glycine receptor, and is detected at a glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
CONCLUSIONS:
Thus, in addition to its role as an inhibitory transmitter, glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
13.3333 mL |
66.6667 mL |
133.3333 mL |
266.6667 mL |
333.3333 mL |
| 5 mM |
2.6667 mL |
13.3333 mL |
26.6667 mL |
53.3333 mL |
66.6667 mL |
| 10 mM |
1.3333 mL |
6.6667 mL |
13.3333 mL |
26.6667 mL |
33.3333 mL |
| 50 mM |
0.2667 mL |
1.3333 mL |
2.6667 mL |
5.3333 mL |
6.6667 mL |
| 100 mM |
0.1333 mL |
0.6667 mL |
1.3333 mL |
2.6667 mL |
3.3333 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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