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  • 甘氨酸

    Glycine

    甘氨酸
    产品编号 CFN70144
    CAS编号 56-40-6
    分子式 = 分子量 C2H5NO2 = 75.0
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The seeds of Glycine max (Linn.) Merr.)
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘氨酸 CFN70144 56-40-6 10mg QQ客服:215959384
    甘氨酸 CFN70144 56-40-6 20mg QQ客服:215959384
    甘氨酸 CFN70144 56-40-6 50mg QQ客服:215959384
    甘氨酸 CFN70144 56-40-6 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • Front Pharmacol.2021, 12:762829.
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  • Int Immunopharmacol.2022, 106:108603.
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Int J Mol Sci.2019, 21(1):E265
  • Arch Biochem Biophys.2020, 687:108363.
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  • ...
  • 生物活性
    Description: Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
    Targets: NMDA
    In vitro:
    Nature,1987 Feb 5-11;325(6104):529-31.
    Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]
    Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
    METHODS AND RESULTS:
    We report here that this response exhibits another remarkable property: it is dramatically potentiated by glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive glycine receptor, and is detected at a glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
    CONCLUSIONS:
    Thus, in addition to its role as an inhibitory transmitter, glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 13.3333 mL 66.6667 mL 133.3333 mL 266.6667 mL 333.3333 mL
    5 mM 2.6667 mL 13.3333 mL 26.6667 mL 53.3333 mL 66.6667 mL
    10 mM 1.3333 mL 6.6667 mL 13.3333 mL 26.6667 mL 33.3333 mL
    50 mM 0.2667 mL 1.3333 mL 2.6667 mL 5.3333 mL 6.6667 mL
    100 mM 0.1333 mL 0.6667 mL 1.3333 mL 2.6667 mL 3.3333 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    土波台文碱; Tubotaiwine CFN96116 6711-69-9 C20H24N2O2 = 324.4 5mg QQ客服:2056216494
    2,4,7-三羟基-9,10-二氢菲; 2,4,7-Trihydroxy-9,10-dihydrophenanthrene CFN91102 70205-52-6 C14H12O3 = 228.25 5mg QQ客服:2159513211
    鸡毛松双黄酮A; Imbricataflavone A CFN91946 133336-96-6 C33H24O10 = 580.54 5mg QQ客服:3257982914
    3-丁酰基莨菪烷; 3-Butyryloxytropane CFN00208 19038-34-7 C12H21NO2 = 211.30 5mg QQ客服:1413575084

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