甘氨酸

Glycine

	产品编号	CFN70144
	CAS编号	56-40-6
	分子式 = 分子量	C₂H₅NO₂ = 75.0
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Alkaloids
	植物来源	The seeds of Glycine max (Linn.) Merr.）
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甘氨酸	CFN70144	56-40-6	10mg	QQ客服：3257982914
甘氨酸	CFN70144	56-40-6	20mg	QQ客服：3257982914
甘氨酸	CFN70144	56-40-6	50mg	QQ客服：3257982914
甘氨酸	CFN70144	56-40-6	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

The Vancouver Prostate Centre (VPC) (Canada)

Universidade do Porto (Portugal)

Rio de Janeiro State University (Brazil)

University of Hawaii Cancer Center (USA)

FORTH-IMBB (Greece)

University of Parma (Italy)

University of Madras (India)

University of East Anglia (United Kingdom)

Georgia Institute of Technology (USA)

University of Medicine and Pharmacy (Romania)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Uniwersytet Jagielloński w Krakowie (Poland)

Amity University (India)

University of Queensland (Australia)

More...

Description:

Glycine is an inhibitory transmitter, it may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.

Targets:

NMDA

In vitro:

Nature,1987 Feb 5-11;325(6104):529-31.

Glycine Potentiates the NMDA Response in Cultured Mouse Brain Neurons.[Reference: WebLink]

Transmitters mediating 'fast' synaptic processes in the vertebrate central nervous system are commonly placed in two separate categories that are believed to exhibit no interaction at the receptor level. The 'inhibitory transmitters' (such as glycine and GABA) are considered to act only on receptors mediating a chloride conductance increase, whereas 'excitatory transmitters' (such as L-glutamate) are considered to activate receptors mediating a cationic conductance increase. The best known excitatory receptor is that specifically activated by N-methyl-D-aspartate (NMDA) which has recently been characterized at the single channel level. The response activated by NMDA agonists is unique in that it exhibits a voltage-dependent Mg block.
METHODS AND RESULTS:
We report here that this response exhibits another remarkable property: it is dramatically potentiated by glycine. This potentiation is not mediated by the inhibitory strychnine-sensitive glycine receptor, and is detected at a glycine concentration as low as 10 nM. The potentiation can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
CONCLUSIONS:
Thus, in addition to its role as an inhibitory transmitter, glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
金粉蕨亭; Onitin	CFN98898	53823-02-2	C₁₅H₂₀O₃ = 248.3	5mg	QQ客服：215959384
(-)-白果内酯; (-)-Bilobalide	CFN99789	33570-04-6	C₁₅H₁₈O₈ = 326.30	20mg	QQ客服：1457312923
1-氯茚满; 1-Chloroindan	CFN90090	35275-62-8	C₉H₉Cl = 152.62	20mg	QQ客服：3257982914
络塞琳; Rosarin	CFN99178	84954-93-8	C₂₀H₂₈O₁₀ = 428.43	10mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	13.3333 mL	66.6667 mL	133.3333 mL	266.6667 mL	333.3333 mL
5 mM	2.6667 mL	13.3333 mL	26.6667 mL	53.3333 mL	66.6667 mL
10 mM	1.3333 mL	6.6667 mL	13.3333 mL	26.6667 mL	33.3333 mL
50 mM	0.2667 mL	1.3333 mL	2.6667 mL	5.3333 mL	6.6667 mL
100 mM	0.1333 mL	0.6667 mL	1.3333 mL	2.6667 mL	3.3333 mL