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  • 栀子苷

    Gardenoside

    栀子苷
    产品编号 CFN90237
    CAS编号 24512-62-7
    分子式 = 分子量 C17H24O11 = 404.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The fruits of Gardenia jasminoides Ellis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    栀子苷 CFN90237 24512-62-7 1mg QQ客服:1413575084
    栀子苷 CFN90237 24512-62-7 5mg QQ客服:1413575084
    栀子苷 CFN90237 24512-62-7 10mg QQ客服:1413575084
    栀子苷 CFN90237 24512-62-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sant Gadge Baba Amravati University (India)
  • Universidade de Franca (Brazil)
  • Washington State University (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Worcester Polytechnic Institute (USA)
  • MTT Agrifood Research Finland (Finland)
  • Chang Gung University (Taiwan)
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  • Vin?a Institute of Nuclear Sciences (Serbia)
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  • Texas A&M University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Int J Mol Med.2019, 43(6):2516-2522
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Korean J Acupunct2020, 37:104-121
  • PLoS One.2017, 12(8):e0181191
  • BMB Rep.2018, 51(5):249-254
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Antioxidants (Basel).2021, 10(9):1487.
  • Internoational J of Toxicology2020, 10.1177.
  • Biochem Pharmacol.2020, 178:114083
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Journal of Analytical Chemistry2017, 854-861
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Institute of Food Science & Technology2021, 45(9).
  • Food Funct.2022, doi: 10.1039
  • Food Sci Nutr.2019, 8(1):246-256
  • Appl. Sci.2020, 10(20), 7323.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Phytomedicine.2022, 100:154058.
  • ...
  • 生物活性
    Description: Gardenoside has hepatoprotective, pain‑relieving, and anti-mastitis effects. it may be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity. Gardenoside may be considered potential drug candidates that target P2X3 and P2X7 purine receptors.
    Targets: NF-kB | Antifection | MCP-1 | TNF-α | MPO | P2X3 receptor | P2X7 receptor | IL Receptor
    In vitro:
    Int J Mol Sci . 2015 Nov 20;16(11):27749-56.
    Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes[Pubmed: 26610473]
    Abstract Gardenoside is one of the most important effective extractions of a herb for its hepatoprotective properties. The aim of this study was to address the mechanism of Gardenoside on HepG2 cellular steatosis induced by free fatty acids (FFAs). The model of HepG2 steatosis was duplicated by oleic and palmitic acid at the proportion of 2:1 (FFAs mixture) for 24 h, then lipid toxicity was induced. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) were used to detect cell viability and Oil Red O staining method was used to judge the lipid accumulation respectively. Inflammatory cytokines TNF-α, IL-1β, IL-6 and intracellular NFκB were measured after 24 h. The steatosis was significantly decreased after Gardenoside treatment without cytotoxicity. TNF-α, IL-1β, IL-6 were modulated to HepG2 cells by treatment of Gardenoside. In the meantime, the activation of NFκB was inhibited by Gardenoside. Gardenoside has a protective effect on FFA-induced cellular steatosis in HepG2 cells which indicates that Gardenoside might be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity. Keywords: HepG2; NFκB; free fatty acid; gardenoside; inflammatory cytokines; steatosis.
    In vivo:
    Chinese Journal of Information on Tcm, 2004, 11(6):500-502.
    Effect of Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin on MCP-1 in the Ischemic Cerebral Tissue of Rats after Middle Cerebral Artery Occlusion.[Reference: WebLink]
    To study the effect of Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin on the protein levels of monocyte chemoattractant protein (MCP-1) in the ischemic cerebral tissue of rats after middle cerebral artery occlusion in rats.
    METHODS AND RESULTS:
    The 110 male SD rats were randomly assigned to the normal group, middle cerebral artery occlusion for 12 hours group and Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin cure middle cerebral artery occlusion for 12 hours group, middle cerebral artery occlusion for 24 hours group and Concha Margatitifera Usta, Cholic Acid, Gardenoside, Baicalin cure middle cerebral artery occlusion for 24 hours group. The protein levels of MCP-1 were measured by enzyme linked immunosorbent assay (ELISA). The protein level of MCP-1 of the ischemic cerebral tissue of rats in the middle cerebral artery occlusion for 12 hours group was markedly increased than the normal group (P0.05). The protein level of MCP-1 of the ischemic cerebral tissue of rats in Concha Margatitifera Usta and Gardenoside cure middle cerebral artery occlusion for 12 hours group were significantly lower than it in the middle cerebral artery occlusion for 12 hours group (P0.01). There was no significant change on the protein level of MCP-1 in the ischemic cerebral tissue of rats between Cholic Acid, Baicalin cure middle cerebral artery occlusion for 12 hours group and the middle cerebral artery occlusion for 12 hours group. The protein level of MCP-1 of the ischemic cerebral tissue of rats in the middle cerebral artery occlusion for 24 hours group was markedly increased than the normal group (P0.05). The protein level of MCP-1 of the ischemic cerebral tissue of rats in the Concha Margatitifera Usta, Cholic Acid, Gardenoside ,Baicalin cure middle cerebral artery occlusion for 24 hours group were significantly lower than it in the middle cerebral artery occlusion for 24 hours group (P0.05 or P0.01).
    CONCLUSIONS:
    Reducing the level of MCP-1 of the ischemic cerebral tissue of rats after ischemia may be one of the most important ways for the neuroprotective effects the middle cerebral artery occlusion group.
    Chinese Veterinary Science, 2013, 43(8):876-880.
    Inhibited effects of gardenoside on the LPS-induced mice mastitis[Reference: WebLink]

    METHODS AND RESULTS:
    To investigate the protective effects of gardenoside on the mice against mastitis,48 male and female mice were paired and randomly divided into 6 groups.Mouse mastitis models were established by pouring LPS into mammary gland after farrowing.Female mice with mastitis were treated with different concentrations of gardenoside(25,50 and 100 mg/kg) and dexamethasone,respectively. Mammary glands of the mice were collected at 24 h after the treatment to study the effects of gardenoside on the histopathology and the expression of myeloperoxidase(MPO),TNF-α,IL-6 and IL-1β. In result,the expression levels of TNF-α,IL-6 and IL-1β were significantly higher in the LPS group than the normal group,indicating the model of mastitis was established successfully in this study.Mammary gland pathological damages were significantly inhibited by gardenoside treatment compared with the LPS group(P0.01).MPO expression levels were decreased with the treatment of low,medium and high doses of gardenoside,and the expression levels of TNF-α,IL-6 and IL-1β were significantly lower in the gardenoside group than the dexamethasone group.
    CONCLUSIONS:
    These results indicated that gardenoside has inhibitory effect on mice mastitis,and the inhibitory effect exhibits a dose-dependent manner.
    J Recept Signal Transduct Res . 2018 Jun;38(3):198-203.
    Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors[Pubmed: 29932348]
    Abstract Objectives: Here, using rat model, we investigated the roles of gardenoside in the chronic constriction injury (CCI) of the ischiadic nerve. Methods: Bennett and Xie's unilateral sciatic nerve CCI model was used in this study. A total of 60 rats were divided into control group (CN), sham group (Sham), CCI group, and gardenoside administrated CCI group. An aliquot of 5 mL gardenoside solution was administrated through gavage once per day for 14 d. Mechanical withdrawal threshold (MWT) and the thermal withdrawal latency (TWL) were detected. The levels of inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in spinal fluid were detected by ELISA. By using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot, we analyzed the expression of P2X purinoceptor 3 and 7 (P2X3 and P2X7 receptors) in different groups. The expression of p-ERK/ERK and p-p38/p38 were also detected by western blot. Results: We found out that gardenoside could significantly improve the sciatica by partially restore the decrease of MWT and TWL in CCI rats. The levels of iNOS, IL-1β, and TNF-α were higher in CCI group (p < .05). The expressions of P2X3 and P2X7 were significantly increased in the CCI rats compared to control rats (p < .05). The levels of p-ERK/ERK and p-p38/p38 were also obviously increased in CCI group (p < .05). After treated with the gardenoside, these increases were decreased. Conclusions: These results indicated that gardenoside may be able to relief CCI-induced neuropathic pain by regulating the P2X3 and the P2X7 expression on the ischiadic nerve. Keywords: Gardenoside; P2X3; P2X7; inflammation; ischiadic nerve chronic constriction injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.473 mL 12.3649 mL 24.7298 mL 49.4597 mL 61.8246 mL
    5 mM 0.4946 mL 2.473 mL 4.946 mL 9.8919 mL 12.3649 mL
    10 mM 0.2473 mL 1.2365 mL 2.473 mL 4.946 mL 6.1825 mL
    50 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9892 mL 1.2365 mL
    100 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    山茱萸苷; Cornin CFN98160 548-37-8 C17H24O10 = 388.37 20mg QQ客服:3257982914
    戟叶马鞭草苷; Hastatoside CFN96588 50816-24-5 C17H24O11 = 404.37 20mg QQ客服:215959384
    Griselinoside; Griselinoside CFN97199 71035-06-8 C18H24O12 = 432.4 5mg QQ客服:2932563308
    Garjasmin; Garjasmin CFN99492 144868-43-9 C11H12O5 = 224.2 5mg QQ客服:2159513211
    Gardenine; Gardenine CFN99447 139682-36-3 C11H13NO4 = 223.2 5mg QQ客服:215959384
    栀子苷; Gardenoside CFN90237 24512-62-7 C17H24O11 = 404.37 5mg QQ客服:2932563308
    Splendoside; Splendoside CFN96355 81969-41-7 C17H26O11 = 406.4 5mg QQ客服:215959384
    续断苷A; Dipsanoside A CFN90753 889678-62-0 C66H90O37 = 1475.4 10mg QQ客服:2159513211
    续断苷B; Dipsanoside B CFN90754 889678-64-2 C66H90O37 = 1475.4 10mg QQ客服:2159513211
    7-去氧-10-羟基马钱苷元; 7-Deoxy-10-hydroxyloganetin CFN89296 76267-48-6 C11H16O5 = 228.24 5mg QQ客服:2932563308

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