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  • Galeopsin

    • Galeopsin

    Galeopsin

    Galeopsin
    		产品编号 CFN89064
    CAS编号 76475-16-6
    分子式 = 分子量 C22H32O5 = 376.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The aerial parts of Leonurus heterophyllus SW.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Galeopsin CFN89064 76475-16-6 1mg QQ客服：2159513211
    Galeopsin CFN89064 76475-16-6 5mg QQ客服：2159513211
    Galeopsin CFN89064 76475-16-6 10mg QQ客服：2159513211
    Galeopsin CFN89064 76475-16-6 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Monash University Malaysia (Malaysia)
  • Almansora University (Egypt)
  • University of Helsinki (Finland)
  • National Chung Hsing University (Taiwan)
  • University of Hawaii Cancer Center (USA)
  • University of Amsterdam (Netherlands)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Tokyo Woman's Christian University (Japan)
  • University of Padjajaran (Indonesia)
  • Colorado State University (USA)
  • Monash University Sunway Campus (Malaysia)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Illinois (USA)
  • Mahidol University (Thailand)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(24):16000.
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • Pharmacol Rep.2022, 74(1):175-188.
  • Biomolecules.2023, 13(2):227.
  • PLoS One.2021, 16(9):e0257243.
  • ACS Nano.2018, 12(4):3385-3396
  • Research Square2021, 10.21203.
  • Spectrochim Acta A2019, 210:372-380
  • Heliyon2022, 8(2):e08866.
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • ACS Synth Biol.2022, doi: 10.1021.
  • Biomed Pharmacother.2023, 163:114785.
  • Plants (Basel).2022, 11(21):2947.
  • J Appl Biol Chem2022, 65:343−348.
  • Molecules2022, 27(12):3903.
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Int J Mol Sci.2023, 24(14):11496.
  • Separations2023, 10(2), 131.
  • J Med Food.2022, 25(3):272-280.
  • Molecules.2020, 25(20):4851.
  • Nutrients.2020, 12(12):3607.
  • Molecules2022, 27(3),1140.
  • ...
    • 生物活性
    Description: Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines.
    Targets: TNF-α
    In vitro:
    Phytochem Anal. 2017 Sep;28(5):404-409.
    Localisation of Two Bioactive Labdane Diterpenoids in the Peltate Glandular Trichomes of Leonurus japonicus by Laser Microdissection Coupled with UPLC-MS/MS.[Pubmed: 28485033 ]
    Glandular trichomes of plants are biochemical factories that could produce, store and secrete copious pharmaceutically important natural products. The Labiatae plant Leonurus japonicus is an important traditional Chinese medicine used to treat gynecological diseases, and has abundant peltate glandular trichomes (PGTs), in which the secondary metabolites accumulated are still unknown. To study the secondary metabolites specifically accumulated in the PGTs of L. japonicus and their biological activities, and provide a new way to pinpoint bioactive natural products from plants.
    METHODS AND RESULTS:
    Morphology of the trichomes on L. japonicus were observed under a scanning electron microscope. The PGTs of L. japonicus were precisely collected using laser microdissection (LMD) and analysed for their secondary metabolites with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Targeted compounds were isolated with classical phytochemical methods, and their structures were elucidated by spectroscopic analysis. Biological activities were evaluated by in vitro assays. Two labdane diterpenoids, leoheterin (1) and galeopsin (2), were localised in the PGTs of L. japonicus. Antithrombotic activity of 1 in anti-platelet aggregation assay induced by arachidonic acid was observed. Both compounds showed potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α. In addition, anti-proliferative effect of both compounds on several cancer cell lines was also detected.
    CONCLUSIONS:
    Two bioactive labdane diterpenoids were localised in the PGTs of L. japonicus. The findings suggested that it might be an efficient approach to explore bioactive natural products from the glandular trichomes of medicinal plants with LMD-UPLC/MS/MS.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6561 mL 13.2806 mL 26.5611 mL 53.1223 mL 66.4028 mL
    5 mM 0.5312 mL 2.6561 mL 5.3122 mL 10.6245 mL 13.2806 mL
    10 mM 0.2656 mL 1.3281 mL 2.6561 mL 5.3122 mL 6.6403 mL
    50 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.0624 mL 1.3281 mL
    100 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.5312 mL 0.664 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    果药烯酮; Hedychenone CFN98942 56324-54-0 C20H26O2 = 298.4 5mg QQ客服：215959384
    11,12-二氢-7-羟基草果药烯酮; 11,12-Dihydro-7-hydroxyhedychenone CFN89088 60149-07-7 C20H28O3 = 316.44 5mg QQ客服：1457312923
    Isoleojaponin; Isoleojaponin CFN89151 1840966-49-5 C20H26O3 = 314.42 5mg QQ客服：1413575084
    8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione; 8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione CFN89116 76475-32-6 C22H32O5 = 376.49 5mg QQ客服：1457312923
    6-Dehydroxy-8-hydroxygaleopsinolone; 6-Dehydroxy-8-hydroxygaleopsinolone CFN89108 87440-66-2 C20H28O3 = 316.44 5mg QQ客服：1457312923
    Persianone; Persianone CFN89065 170894-20-9 C40H56O6 = 632.88 5mg QQ客服：1457312923
    Hispanone; Hispanone CFN89110 82462-67-7 C20H28O2 = 300.44 5mg QQ客服：2056216494
    6α-Hydroxyhispanone; 6alpha-Hydroxyhispanone CFN89123 596814-48-1 C20H28O3 = 316.44 5mg QQ客服：2159513211
    6beta-Hydroxyhispanone; 6beta-Hydroxyhispanone CFN89162 170711-93-0 C20H28O3 = 316.44 5mg QQ客服：3257982914
    Leojaponin; Leojaponin CFN89087 864817-63-0 C20H26O3 = 314.42 5mg QQ客服：1457312923

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