Galeopsin

	产品编号	CFN89064
	CAS编号	76475-16-6
	分子式 = 分子量	C₂₂H₃₂O₅ = 376.49
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The aerial parts of Leonurus heterophyllus SW.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Galeopsin	CFN89064	76475-16-6	1mg	QQ客服：3004468088
Galeopsin	CFN89064	76475-16-6	5mg	QQ客服：3004468088
Galeopsin	CFN89064	76475-16-6	10mg	QQ客服：3004468088
Galeopsin	CFN89064	76475-16-6	20mg	QQ客服：3004468088

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Ateneo de Manila University (Philippines)

Helmholtz Zentrum München (Germany)

Semmelweis Unicersity (Hungary)

Korea Intitute of Science and Technology (KIST) (Korea)

Biotech R&D Institute (USA)

Cornell University (USA)

University of Dicle (Turkey)

University of Queensland (Australia)

Medizinische Universit?t Wien (Austria)

Mendel University in Brno (Czech Republic)

Srinakharinwirot University (Thailand)

Hamdard University (India)

Universidade do Porto (Portugal)

Universite Libre de Bruxelles (Belgium)

More...

Description:

Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines.

Targets:

TNF-α

In vitro:

Phytochem Anal. 2017 Sep;28(5):404-409.

Localisation of Two Bioactive Labdane Diterpenoids in the Peltate Glandular Trichomes of Leonurus japonicus by Laser Microdissection Coupled with UPLC-MS/MS.[Pubmed: 28485033 ]

Glandular trichomes of plants are biochemical factories that could produce, store and secrete copious pharmaceutically important natural products. The Labiatae plant Leonurus japonicus is an important traditional Chinese medicine used to treat gynecological diseases, and has abundant peltate glandular trichomes (PGTs), in which the secondary metabolites accumulated are still unknown. To study the secondary metabolites specifically accumulated in the PGTs of L. japonicus and their biological activities, and provide a new way to pinpoint bioactive natural products from plants.
METHODS AND RESULTS:
Morphology of the trichomes on L. japonicus were observed under a scanning electron microscope. The PGTs of L. japonicus were precisely collected using laser microdissection (LMD) and analysed for their secondary metabolites with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Targeted compounds were isolated with classical phytochemical methods, and their structures were elucidated by spectroscopic analysis. Biological activities were evaluated by in vitro assays. Two labdane diterpenoids, leoheterin (1) and galeopsin (2), were localised in the PGTs of L. japonicus. Antithrombotic activity of 1 in anti-platelet aggregation assay induced by arachidonic acid was observed. Both compounds showed potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α. In addition, anti-proliferative effect of both compounds on several cancer cell lines was also detected.
CONCLUSIONS:
Two bioactive labdane diterpenoids were localised in the PGTs of L. japonicus. The findings suggested that it might be an efficient approach to explore bioactive natural products from the glandular trichomes of medicinal plants with LMD-UPLC/MS/MS.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
狗牙花碱E; Coronarin E	CFN99275	117591-81-8	C₂₀H₂₈O = 284.4	5mg	QQ客服：3004468087
姜花素A；狗牙花碱A; Coronarin A	CFN99301	119188-33-9	C₂₀H₂₈O₂ = 300.4	5mg	QQ客服：3004468091
滇姜花素A; Yunnancoronarin A	CFN99689	162762-93-8	C₂₀H₂₈O₂ = 300.4	5mg	QQ客服：3004468091
果药烯酮; Hedychenone	CFN98942	56324-54-0	C₂₀H₂₆O₂ = 298.4	5mg	QQ客服：3004468520
11,12-二氢-7-羟基草果药烯酮; 11,12-Dihydro-7-hydroxyhedychenone	CFN89088	60149-07-7	C₂₀H₂₈O₃ = 316.44	5mg	QQ客服：3004468091
Isoleojaponin; Isoleojaponin	CFN89151	1840966-49-5	C₂₀H₂₆O₃ = 314.42	5mg	QQ客服：3004468091
8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione; 8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione	CFN89116	76475-32-6	C₂₂H₃₂O₅ = 376.49	5mg	QQ客服：3004468088
6-Dehydroxy-8-hydroxygaleopsinolone; 6-Dehydroxy-8-hydroxygaleopsinolone	CFN89108	87440-66-2	C₂₀H₂₈O₃ = 316.44	5mg	QQ客服：3004468520
Persianone; Persianone	CFN89065	170894-20-9	C₄₀H₅₆O₆ = 632.88	5mg	QQ客服：3004468088
Hispanone; Hispanone	CFN89110	82462-67-7	C₂₀H₂₈O₂ = 300.44	5mg	QQ客服：3004468088

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6561 mL	13.2806 mL	26.5611 mL	53.1223 mL	66.4028 mL
5 mM	0.5312 mL	2.6561 mL	5.3122 mL	10.6245 mL	13.2806 mL
10 mM	0.2656 mL	1.3281 mL	2.6561 mL	5.3122 mL	6.6403 mL
50 mM	0.0531 mL	0.2656 mL	0.5312 mL	1.0624 mL	1.3281 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.5312 mL	0.664 mL