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  • 七叶皂苷IIB

    Escin IIB

    七叶皂苷IIB
    产品编号 CFN80482
    CAS编号 158800-83-0
    分子式 = 分子量 C54H84O23 = 1101.24
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Aesculus hippocastanum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    七叶皂苷IIB CFN80482 158800-83-0 1mg QQ客服:2056216494
    七叶皂苷IIB CFN80482 158800-83-0 5mg QQ客服:2056216494
    七叶皂苷IIB CFN80482 158800-83-0 10mg QQ客服:2056216494
    七叶皂苷IIB CFN80482 158800-83-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Perugia (Italy)
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  • University of Cincinnati (USA)
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  • Shanghai Institute of Organic Chemistry (China)
  • Pennsylvania State University (USA)
  • Instituto de Investigaciones Agropecuarias (Chile)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Appl Biol Chem.2022, 65(4):pp.463-469.
  • Molecules.2021, 26(23):7390.
  • Planta Med.2016, 82(13):1208-16
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Plants.2024, 13(10):1348;
  • Pharmacol Rep.2017, 69(6):1224-1231
  • J Chromatogr A.2024, 1714:464544.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • LWT2024, 200:116184.
  • Agriculture.2022, 12(3), 342.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • Drug Des Devel Ther.2020, 14:61-71
  • Sci Rep.2023, 13(1):14594.
  • J Ethnopharmacol.2024, 318(Pt B):116961.
  • J Pharm Biomed Anal.2022, 207:114398.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Phytomedicine.2024, 155760.
  • Int J Mol Sci.2018, 19(2)
  • Chung Shan Medical University2020, US20200323790A1
  • Elife.2021, 10:e68058.
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  • ...
  • 生物活性
    Description: Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice. Escin IIB shows gastroprotection on ethanol-induced gastric mucosal lesions, whereas endogenous prostaglandins, NO, capsaicin-sensitive afferent neurons, and the sympathetic nervous system participate; it also enhances Mg(2+) absorption from the digestive tract in mice, in which the constitutive, but not the inducible, NO synthase plays an important role.
    Targets: NO | NOS
    In vivo:
    Eur J Pharmacol. 2000 Jan 17;387(3):337-42.
    Enhancement by escins Ib and IIb of Mg(2+) absorption from digestive tract in mice: role of nitric oxide.[Pubmed: 10650180]
    The effects of escin Ib and Escin IIB isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice.
    METHODS AND RESULTS:
    Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The serum Mg(2+) levels were determined 30, 60, 120 and 180 min after administration of MgSO(4). Escin Ib and Escin IIB (12.5 and 25 mg/kg) significantly increased the serum Mg(2+) by 10.0-27.3%, 30, 120 and 180 min after administration of the samples, and 30, 60, 120 and 180 min after administration of MgSO(4). Escin Ib and Escin IIB(12.5 mg/kg) significantly decreased the Mg(2+) content in the small intestinal fluid in MgSO(4)-loaded mice, but did not increase the serum Mg(2+) levels in normal mice. The effects of Escin Ib and Escin IIB (12.5 mg/kg) on serum Mg(2+) levels were attenuated in a dose-related manner by the pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME, 3-20 mg/kg, i.p., an inhibitor of constitutive and inducible NO synthase), but not with D-NAME (10 mg/kg, i.p., the inactive enantiomer of L-NAME) or dexamethasone (0.05 and 0.5 mg/kg, s.c., an inhibitor of inducible NO synthase). The effect of L-NAME was reversed by L-arginine (600 mg/kg, i.p., a substrate of NO synthase), but not by D-arginine (900 mg/kg, i.p., the enantiomer of L-arginine).
    CONCLUSIONS:
    These results suggest that Escin Ib and Escin IIB enhance Mg(2+) absorption from the digestive tract in mice, in which the constitutive, but not the inducible, NO synthase plays an important role.
    Biol Pharm Bull. 1997 Oct;20(10):1092-5.
    Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals.[Pubmed: 9353571]
    We investigated the effects of escins Ia, Ib, and IIb isolated from horse chestnut, the seeds of Aesculus hippocastanum L., and desacylescins I and II obtained by alkaline hydrolysis of escins on acute inflammation in animals (p.o.).
    METHODS AND RESULTS:
    Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibited the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escin Ib, Escin IIa, and Escin IIB (50-200 mg/kg) also inhibited that induced by serotonin in rats, but escin Ia didn't. Escin Ib, Escin Ia, Escin IIa, and Escin IIB (200 mg/kg) inhibited the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and Escin Ib, Escin IIa, and Escin IIB(50-200 mg/kg) inhibited the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Desacylescins I and II (200 mg/kg) showed no effect.
    CONCLUSIONS:
    With regard to the relationship between their chemical structures and activities, the acyl groups in escins were essential. Escin Ib, Escin IIa, and Escin IIB with either the 21-angeloyl group or the 2'-O-xylopyranosyl moiety showed more potent activities than escin Ia which had both the 21-tigloyl group and the 2'-O-glucopyranosyl moiety.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9081 mL 4.5403 mL 9.0807 mL 18.1613 mL 22.7017 mL
    5 mM 0.1816 mL 0.9081 mL 1.8161 mL 3.6323 mL 4.5403 mL
    10 mM 0.0908 mL 0.454 mL 0.9081 mL 1.8161 mL 2.2702 mL
    50 mM 0.0182 mL 0.0908 mL 0.1816 mL 0.3632 mL 0.454 mL
    100 mM 0.0091 mL 0.0454 mL 0.0908 mL 0.1816 mL 0.227 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    环(苯丙氨酸-缬氨酸)二肽; Cyclo(Phe-Val) CFN90274 14474-71-6 C14H18N2O2 = 246.31 10mg QQ客服:1413575084
    8-乙酰基-7-甲氧基香豆素; 8-Acetyl-7-methoxycoumarin CFN70467 89019-07-8 C12H10O4 = 218.2 5mg QQ客服:2056216494
    Glucocamelinin; Glucocamelinin CFN00501 67884-10-0 C18H34KNO10S3 = 559.8 5mg QQ客服:1413575084
    前胡香豆精E; Qianhucoumarin E CFN92597 156041-02-0 C19H18O6 = 342.4 5mg QQ客服:3257982914

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