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  • 榼藤酰胺A

    Entadamide A

    榼藤酰胺A
    产品编号 CFN91664
    CAS编号 100477-88-1
    分子式 = 分子量 C6H11NO2S = 161.22
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Entada phaseoloides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    榼藤酰胺A CFN91664 100477-88-1 1mg QQ客服:2056216494
    榼藤酰胺A CFN91664 100477-88-1 5mg QQ客服:2056216494
    榼藤酰胺A CFN91664 100477-88-1 10mg QQ客服:2056216494
    榼藤酰胺A CFN91664 100477-88-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Beira Interior (Portugal)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Michigan State University (USA)
  • Osmania University (India)
  • Mendel University in Brno (Czech Republic)
  • Seoul National University (Korea)
  • Universit?t Basel (Switzerland)
  • University of Oslo (Norway)
  • University of Illinois at Chicago (USA)
  • Ain Shams University (Egypt)
  • University of Vienna (Austria)
  • Sapienza University of Rome (Italy)
  • FORTH-IMBB (Greece)
  • Seoul National University of Science and Technology (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • LWT2020, 130:109535
  • J Appl Pharm Sci.2022, 12(04):044-053
  • Int Immunopharmacol.2020, 90:107268.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Microchemical Journal2024, 200:110475
  • Univerzita Karlova2021, 20.500.11956.
  • Primary and Industrial.2018, 52(11)
  • Life Sci.2019, 216:259-270
  • Front Chem.2023, 11:1245071.
  • Foods.2023, 12(6):1130.
  • Environ Toxicol.2023, 23929.
  • Front. Pharmacol.2022, 901563.
  • Agronomy2020, 10(10),1489
  • Molecules.2018, 23(3):E615
  • J of Dentistry & Oral Health2019, 2641-1962
  • Front Pharmacol.2023, 14:1244655.
  • Phytomedicine.2024, 122:155065.
  • Front Pharmacol.2017, 8:205
  • Cells.2022, 11(6):931.
  • Phytomedicine.2023, 117:154929.
  • Molecules.2021, 26(6):1635.
  • Biomed Pharmacother.2024, 171:116166.
  • Toxicol Rep.2021, 8:1131-1142.
  • ...
  • 生物活性
    Description: Entadamide A has anti-inflammatory, anti-oxidative stress activity.
    In vitro:
    Chem Pharm Bull (Tokyo) . 1989 Jul;37(7):1932-1933.
    Synthesis of entadamide A and entadamide B isolated from Entada phaseoloides and their inhibitory effects on 5-lipoxygenase[Pubmed: 2805174]
    Two new sulfur-containing amides, entadamide A (1) and entadamide B (2), isolated from the seeds of Entada phaseoloides, were synthesized by the addition reaction of methanethiol to propiolic acid (5) followed by condensation with ethanolamine by the use of dicyclohexylcarbadiimide. These compounds inhibited the 5-lipoxygenase activity of RBL-1 cells at 10(-4) g/ml. This finding suggests that entadamides A and B may be examples of a new type of antiinflammatory drug.
    Biomed Chromatogr . 2021 Dec;35(12):e5232.
    Optimization, extraction, and purification of three bioactive compounds from Entada phaseoloides by high-speed countercurrent chromatography[Pubmed: 34424556]
    Abstract The objective of this paper was to develop a preparative method for the separation and purification of phaseoloidin, entadamide A, and entadamide A-β-D-glucopyranoside from the crude extract of Entada phaseoloides by high-speed countercurrent chromatography (HSCCC) for the first time. Optimized by orthogonal experiments, the extraction conditions were extraction temperature of 65°C, solid-to-liquid ratio of 1:15 (g/mL), ethanol concentration of 40%, and extraction time of 2.5 h. Using n-butanol-acetic acid-water (4:1:5, v/v/v) as the two-phase solvent system, 38.79 mg phaseoloidin (the purity was 99.3% with a recovery of 98.1%), 34.85 mg entadamide A (the purity was 96.4% with a recovery of 98.5%), and 33.97 mg entadamide A-β-D-glucopyranoside (the purity was 98.6% with a recovery of 97.7%) were obtained from 500 mg crude extract by HSCCC in head-to-tail elution mode. The retention ratio of stationary phase was 51.0%. According to the antioxidant activity assays, phaseoloidin, entadamide A, and entadamide A-β-D-glucopyranoside had certain scavenging abilities on 1,1-diphenyl-2-picrylhydrazyl free radicals and hydroxyl free radicals.
    Chem Pharm Bull (Tokyo) . 2003 Dec;51(12):1423-1425.
    Sulfur-containing compounds from Clinacanthus siamensis[Pubmed: 14646322]
    Two new sulfur-containing compounds, trans-3-methylsulfonyl-2-propenol (1) and trans-3-methylsulfinyl-2-propenol (2) were isolated together with trans-3-methylthioacrylamide (3), entadamide A (4) and entadamide C (5) from the leaves of Clinacanthus siamensis. The structures were established on the basis of the spectroscopic data. The compounds were tested for antimalarial and antimycobacterial activity.
    In vivo:
    J Ayurveda Integr Med . Oct-Dec 2020;11(4):464-470.
    Effect of seeds of Entada phaseoloides on chronic restrain stress in mice[Pubmed: 30635249]
    Background: Entada phaseoloides is a well-known medicinal plant traditionally used in Ayurvedic medicine for centuries. Objective: To evaluate the anti-stress activity of seeds of E. phaseoloides in endoplasmic reticulum stress during chronic restrain stress in mice, based on our preliminary screening. Materials and methods: Mice (n = 6/group) were restrained daily for 6 h in 50 ml polystyrene tubes for 28 days. Methanolic extract of E. phaseoloides (MEEP) (100 and 200 mg/kg, p.o.) and standard drug, imipramine (10 mg/kg i.p.) were administered daily 45 min prior to restrain from day 22-28. Then, forced swim test (FST) was performed to assess despair behavior. Lipid peroxidation (LPO) and antioxidant enzymes Reduced glutathione (GSH), Superoxide dismutase (SOD) were measured in the hippocampus of mice. 78 kDa Glucose-regulated Protein, 94 kDa Glucose-regulated Protein, C/EBP homologous protein, Caspase-12 expression were quantified by Real Time PCR. Results: MEEP significantly reduced the immobility time in FST (P < 0.001). Significant reduction of LPO (P < 0.05) level and restored antioxidant enzymes viz. GSH (P < 0.001) and SOD towards vehicle control group were observed. Down-regulation of genes GRP 78, GRP 94 (P < 0.001), CHOP and Caspase-12 (P < 0.001) as compared to the chronic restrain stress group was evident, which were upregulated following treatment. Isolation of the active components of the seeds revealed the presence of Oleic acid (1), Entadamide A (2), Entadamide A-beta-d-glucopyranoside (3) and 1-O-protocatechuoyl-β-d-glucose. Conclusion: MEEP altered endoplasmic reticulum stress in chronic restrain stressed mice; however, as an antidepressant it showed a weaker response.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.2027 mL 31.0135 mL 62.027 mL 124.0541 mL 155.0676 mL
    5 mM 1.2405 mL 6.2027 mL 12.4054 mL 24.8108 mL 31.0135 mL
    10 mM 0.6203 mL 3.1014 mL 6.2027 mL 12.4054 mL 15.5068 mL
    50 mM 0.1241 mL 0.6203 mL 1.2405 mL 2.4811 mL 3.1014 mL
    100 mM 0.062 mL 0.3101 mL 0.6203 mL 1.2405 mL 1.5507 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    猫眼草黄素; Chrysosplenetin CFN97026 603-56-5 C19H18O8 = 374.4 20mg QQ客服:2159513211
    N-对香豆酰-N’-咖啡酰腐胺; N-p-coumaroyl-N'-caffeoylputrescine CFN99238 1138156-77-0 C22H24N2O5 = 396.4 5mg QQ客服:2056216494
    藤黄呫吨酮E; Garciniaxanthone E CFN99816 173294-74-1 C28H32O6 = 464.6 5mg QQ客服:1457312923
    红霉素; Erythroskyrin CFN00116 4987-27-3 C26H33NO6 = 455.55 5mg QQ客服:215959384

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