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  • 墨旱莲皂苷II

    Eclalbasaponin II

    墨旱莲皂苷II
    产品编号 CFN70449
    CAS编号 78285-90-3
    分子式 = 分子量 C36H58O9 = 634.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Eclipta prostrata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    墨旱莲皂苷II CFN70449 78285-90-3 1mg QQ客服:215959384
    墨旱莲皂苷II CFN70449 78285-90-3 5mg QQ客服:215959384
    墨旱莲皂苷II CFN70449 78285-90-3 10mg QQ客服:215959384
    墨旱莲皂苷II CFN70449 78285-90-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Siksha O Anusandhan University (India)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Canterbury (New Zealand)
  • Universidade Federal de Santa Catarina (Brazil)
  • Uniwersytet Gdański (Poland)
  • Universite de Lille1 (France)
  • Kitasato University (Japan)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Rio de Janeiro State University (Brazil)
  • Texas A&M University (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Parma (Italy)
  • Aveiro University (Portugal)
  • University of East Anglia (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Enzyme and Microbial Technology2022, 110002.
  • Int J Pharm.2022, 618:121636.
  • Molecules.2020, 25(23):5609.
  • Int J Mol Sci.2023, 24(8):7045.
  • J. Food Composition and Analysis2022, 114:104731
  • Pharmaceuticals (Basel).2024, 17(4):442.
  • Molecules 2022, 27(3),960.
  • Appl. Sci.2021, 11(1),14.
  • J Vet Sci.2020, 21(3):e39.
  • Natural Product Communications2020, doi: 10.1177.
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • Applied Biological Chem. 2020, 26(63).
  • Metabolites.2023, 13(5):625.
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • Asian Journal of Chemistry2014, 26(8):2425
  • J Pharm Biomed Anal.2021, 196:113931.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Research Square2024, rs-4398438
  • Research on Crops.2017, 18(2)
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Molecules2021, 26(1),230
  • J.Food Processing & Preservation2022, jfpp.16666
  • ...
  • 生物活性
    Description: Eclalbasaponin II induces apoptotic and autophagic cell death through the regulation of JNK, p38, and mTOR signaling in human ovarian cancer cells. It also inhibited NF-κB activation stimulated by TNF-α in a dose-dependent manner, with IC50 values ranging from 8.3 ± 0.7 to 13.5 ± 1.0 μM. Eclalbasaponin II shows antimicrobial activity. Eclalbasaponin II ameliorates cholinergic blockade-induced cognitive impairment via AChE inhibition, LTP formation and the activation of Akt-GSK-3β signaling, and that eclalbasaponin II may be a useful to treat cognitive impairment derived from cholinergic dysfunction.
    Targets: NF-κB | TNF-α | Akt | GSK3β | mTOR | p38 | JNK
    In vitro:
    Oriental Pharmacy and Experimental Medicine,2008,8(1):47-52.
    Antimicrobial activity and cytotoxicity of Eclipta prostrata.[Reference: WebLink]
    The plant Eclipta prostrata, a member of the Compositae family, has folkloric reputation of being used as a medicinal agent in Bangladesh.
    METHODS AND RESULTS:
    In the present investigation, attempt was taken to explore the antimicrobial potency and cytotoxicity of its extractives and purified compounds. The methanolic extract of the whole plant, its n-hexane, carbon tetrachloride, chloroform, aqueous soluble fractions and two purified compounds, eclalbasaponin I (1) and eclalbasaponin II (2), obtained from Eclipta prostrata were subjected to screening for inhibition of microbial growth by the disc diffusion method at 300 and 100 ?g/disc for extracts and pure compounds, respectively. In this case, the carbon tetrachloride and chloroform soluble fractions of the methanolic extract appeared very potent in terms of both zone of inhibition and spectrum of activity. However, all the extractives were also subjected to brine shrimp lethality bioassay for preliminary cytotoxicity evaluation.
    CONCLUSIONS:
    Here, the carbon tetrachloride soluble fraction of methanolic extract revealed the strongest cytotoxicity having LC_{50} of 1.318 ?g/ml.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5751 mL 7.8753 mL 15.7505 mL 31.501 mL 39.3763 mL
    5 mM 0.315 mL 1.5751 mL 3.1501 mL 6.3002 mL 7.8753 mL
    10 mM 0.1575 mL 0.7875 mL 1.5751 mL 3.1501 mL 3.9376 mL
    50 mM 0.0315 mL 0.1575 mL 0.315 mL 0.63 mL 0.7875 mL
    100 mM 0.0158 mL 0.0788 mL 0.1575 mL 0.315 mL 0.3938 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢异丹参酮I; Dihydroisotanshinone I CFN90162 20958-18-3 C18H14O3 = 278.30 10mg QQ客服:2159513211
    Triciribine; Triciribine CFN60328 35943-35-2 C13H16N6O4 = 320.3 5mg QQ客服:1413575084
    蝙蝠葛氰苷; Menisdaurin CFN90410 67765-58-6 C14H19NO7 = 313.30 10mg QQ客服:2159513211
    Neoartanin; Neoartanin CFN91660 104196-69-2 C16H18O5 = 290.31 5mg QQ客服:2056216494

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