Diepiserratenediol

	产品编号	CFN89141
	CAS编号	3604-92-0
	分子式 = 分子量	C₃₀H₅₀O₂ = 442.72
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The whole plants of Lycopodium japonicum Thunb.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Diepiserratenediol	CFN89141	3604-92-0	1mg	QQ客服：3257982914
Diepiserratenediol	CFN89141	3604-92-0	5mg	QQ客服：3257982914
Diepiserratenediol	CFN89141	3604-92-0	10mg	QQ客服：3257982914
Diepiserratenediol	CFN89141	3604-92-0	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

The Vancouver Prostate Centre (VPC) (Canada)

Universidad de La Salle (Mexico)

University Medical Center Mainz (Germany)

Washington State University (USA)

Melbourne University (Australia)

Martin Luther University of Halle-Wittenberg (Germany)

Hamdard University (India)

S.N.D.T. Women's University (India)

University of Maryland School of Medicine (USA)

Siksha O Anusandhan University (India)

The Institute of Cancer Research (United Kingdom)

Anna University (India)

National Research Council of Canada (Canada)

National Hellenic Research Foundation (Greece)

More...

Description:

Diepiserratenediol has potential activity to inhibit tumor promotion, it shows potent inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA).

In vitro:

Cancer Lett. 2004 Oct 28;214(2):149-56.

Cancer chemopreventive activity of 3beta-methoxyserrat-14-en-21beta-ol and several serratane analogs on two-stage mouse skin carcinogenesis.[Pubmed: 15363540]

3beta-Methoxyserrat-14-en-21beta-ol (1) and 3alpha-methoxyserrat-14-en-21beta-ol (2) are the most abundant triterpenoids from two Picea plants, Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis and P. jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayr) Rehder, and the total yield of 1 and 2 reach over 1/3 of the chloroform extract of the above two plants.
METHODS AND RESULTS:
This study deals with the potential of anti-tumor promoting activity of 1 and results of the assay of 22 synthetic serratane-type triterpenoids (6)-(27) derived from 1, 2, 21-episerratenediol (3), Diepiserratenediol (4) and 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (5) to discuss the structure-activity relationship. As a preliminary evaluation of their potential to inhibit tumor promotion, the inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) were used. All compounds except for 12 and 19 showed potent inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA), their effects being stronger than that of a positive control oleanolic acid. Compounds 1, 13, 14, 18, 20 and 26 were selected to examine the effect on the in vivo two-stage mouse skin carcinogenesis test induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
CONCLUSIONS:
The most abundant triterpenoid 1 and the synthetic compounds 13 and 14 were found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogenesis test, and compounds 18, 20 and 26 also showed strong inhibitory effects.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
酮基哈共醇; Ketohakonanol	CFN89135	18004-20-1	C₂₉H₄₈O₂ = 428.70	5mg	QQ客服：3257982914
Diepiserratenediol; Diepiserratenediol	CFN89141	3604-92-0	C₃₀H₅₀O₂ = 442.72	5mg	QQ客服：215959384
21-表千层塔烯二醇; 21-Episerratenediol	CFN99495	1449-06-5	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：3257982914
马尾杉醇C; Phlegmanol C	CFN99371	1260-05-5	C₃₂H₅₂O₃ = 484.8	5mg	QQ客服：2056216494
千层塔烯二醇；锯齿石松烯二醇；山芝烯二醇; Serratenediol	CFN98216	2239-24-9	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：1457312923
二乙酸山芝烯二醇酯; Serratenediol diacetate	CFN98339	27832-84-4	C₃₄H₅₄O₄ = 526.8	5mg	QQ客服：1457312923
21-表山芝烯三醇; 21-Episerratriol	CFN98264	24513-57-3	C₃₀H₅₀O₃ = 458.7	5mg	QQ客服：1413575084
山芝烯三醇; Serratriol	CFN99446	13956-52-0	C₃₀H₅₀O₃ = 458.7	5mg	QQ客服：2056216494
石松醇; Lycoclavanol	CFN99445	13956-51-9	C₃₀H₅₀O₃ = 458.7	5mg	QQ客服：1413575084
伸筋草萜宁醇; Lyclaninol	CFN98896	53755-76-3	C₃₀H₅₀O₄ = 474.7	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2588 mL	11.2938 mL	22.5876 mL	45.1753 mL	56.4691 mL
5 mM	0.4518 mL	2.2588 mL	4.5175 mL	9.0351 mL	11.2938 mL
10 mM	0.2259 mL	1.1294 mL	2.2588 mL	4.5175 mL	5.6469 mL
50 mM	0.0452 mL	0.2259 mL	0.4518 mL	0.9035 mL	1.1294 mL
100 mM	0.0226 mL	0.1129 mL	0.2259 mL	0.4518 mL	0.5647 mL