松苓新酸
Dehydrotrametenolic acid
|
|
产品编号 |
CFN90577 |
| CAS编号 |
29220-16-4 |
| 分子式 = 分子量 |
C30H46O3 = 454.69 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Triterpenoids |
| 植物来源 |
The roots of Wolfiporia cocos (Schw.) Ryv. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 松苓新酸 |
CFN90577 |
29220-16-4 |
10mg |
QQ客服：1457312923 |
| 松苓新酸 |
CFN90577 |
29220-16-4 |
20mg |
QQ客服：1457312923 |
| 松苓新酸 |
CFN90577 |
29220-16-4 |
50mg |
QQ客服：1457312923 |
| 松苓新酸 |
CFN90577 |
29220-16-4 |
100mg |
QQ客服：1457312923 |
1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。
2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。
3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
订购流程
1. 在线订购
请联系我们QQ客服
2. 电话订购
请拨打电话：
027-84237683 或 027-84237783
3. 邮件或传真订购
发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680
提供订购信息
为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
1. 产品编号（CAS No.或产品名称）
2. 发货地址
3. 联系方法 (联系人，电话）
4. 开票抬头 (如果需要发票的客户）
5. 发票地址（发货地址与发票地址不同）
发货时间
1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。
2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。
3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Monash University Sunway Campus (Malaysia)
Charles University in Prague (Czech Republic)
Monash University (Australia)
Universidad de Antioquia (Colombia)
National Cancer Center Research Institute (Japan)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
University of Hawaii Cancer Center (USA)
The Ohio State University (USA)
Universidad Miguel Hernández (Spain)
Subang Jaya Medical Centre (Malaysia)
University of Wuerzburg (Germany)
University of Toulouse (France)
Centrum Menselijke Erfelijkheid (Belgium)
University of Lodz (Poland)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Front Cell Dev Biol.2021, 9:638174.
Int J Biol Macromol.2020, 169:342-351
Chem Biol Interact.2023, 378:110487.
Food Chem.2022, 373(Pt B):131364.
Dicle Tip Dergisi2020, 47(2),423-430.
Phytomedicine.2019, 57:95-104
Pharmacognosy Journal.2022, 14,4,327-337.
Cell Physiol Biochem.2019, 52(6):1255-1266
| Description: |
Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug; it can be a potential anticancer agent against H-ras transformed tumor. |
| Targets: |
PARP | Caspase | Akt | ERK | PPAR |
| In vitro: |
| Life Sci. 2006 Jan 2;78(6):607-13. | | Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.[Pubmed: 16112686] | The screening of natural products that preferentially inhibit growth of H-ras transformed rat2 cells vs. rat2 cells was performed to identify H-ras specific growth inhibitor.
METHODS AND RESULTS:
A lanostane-type triterpene acid, dehydrotrametenolic acid (3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid), was isolated from the sclerotium of Poria cocos (Polyporaceae). Dehydrotrametenolic acid selectively inhibited the growth of H-ras transformed cells with a GI(50) value of 40 microM. FACS analysis indicated that the compound exerted its anti-proliferation effects through cell cycle arrest at G2/M phase and accumulation of sub-G1 population. Dehydrotrametenolic acid-induced apoptosis was further confirmed with chromosomal DNA fragmentation, caspase-3 activation, and degradation of PARP and Lamin A/C degradation. The compound also regulated the expression of H-ras, Akt and Erk, which are the downstream proteins of H-ras signaling pathways.
CONCLUSIONS:
The results suggest that dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. |
|
| In vivo: |
| Biol Pharm Bull. 2002 Jan;25(1):81-6. | | Dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of noninsulin-dependent diabetes mellitus to insulin.[Pubmed: 11824563] | We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos WOLF (Polyporaceae), a well-known traditional Chinese medicinal plant.
METHODS AND RESULTS:
We examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus (NIDDM) and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.
CONCLUSIONS:
This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1993 mL |
10.9965 mL |
21.993 mL |
43.986 mL |
54.9825 mL |
| 5 mM |
0.4399 mL |
2.1993 mL |
4.3986 mL |
8.7972 mL |
10.9965 mL |
| 10 mM |
0.2199 mL |
1.0997 mL |
2.1993 mL |
4.3986 mL |
5.4983 mL |
| 50 mM |
0.044 mL |
0.2199 mL |
0.4399 mL |
0.8797 mL |
1.0997 mL |
| 100 mM |
0.022 mL |
0.11 mL |
0.2199 mL |
0.4399 mL |
0.5498 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
部分图片展示
联系方式
电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com
湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房
ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证
天然化合物与对照品的研发和生产。
