松苓新酸

Dehydrotrametenolic acid

	产品编号	CFN90577
	CAS编号	29220-16-4
	分子式 = 分子量	C₃₀H₄₆O₃ = 454.69
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Wolfiporia cocos (Schw.) Ryv.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
松苓新酸	CFN90577	29220-16-4	10mg	QQ客服：3257982914
松苓新酸	CFN90577	29220-16-4	20mg	QQ客服：3257982914
松苓新酸	CFN90577	29220-16-4	50mg	QQ客服：3257982914
松苓新酸	CFN90577	29220-16-4	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade Federal de Pernambuco (UFPE) (Brazil)

Kyushu University (Japan)

University of Illinois (USA)

Max Rubner-Institut (MRI) (Germany)

Universidad de La Salle (Mexico)

Guangzhou Institutes of Biomedicine and Health (China)

VIT University (India)

University of Limpopo (South Africa)

Universita' Degli Studi Di Cagliari (Italy)

University of Mysore (India)

Indian Institute of Science (India)

Institute of Pathophysiology Medical University of Vienna (Austria)

Universidade da Beira Interior (Germany)

Weizmann Institute of Science (Israel)

More...

Description:

Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug; it can be a potential anticancer agent against H-ras transformed tumor.

Targets:

PARP | Caspase | Akt | ERK | PPAR

In vitro:

Life Sci. 2006 Jan 2;78(6):607-13.

Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.[Pubmed: 16112686]

The screening of natural products that preferentially inhibit growth of H-ras transformed rat2 cells vs. rat2 cells was performed to identify H-ras specific growth inhibitor.
METHODS AND RESULTS:
A lanostane-type triterpene acid, dehydrotrametenolic acid (3beta-hydroxylanosta-7,9(11),24-trien-21-oic acid), was isolated from the sclerotium of Poria cocos (Polyporaceae). Dehydrotrametenolic acid selectively inhibited the growth of H-ras transformed cells with a GI(50) value of 40 microM. FACS analysis indicated that the compound exerted its anti-proliferation effects through cell cycle arrest at G2/M phase and accumulation of sub-G1 population. Dehydrotrametenolic acid-induced apoptosis was further confirmed with chromosomal DNA fragmentation, caspase-3 activation, and degradation of PARP and Lamin A/C degradation. The compound also regulated the expression of H-ras, Akt and Erk, which are the downstream proteins of H-ras signaling pathways.
CONCLUSIONS:
The results suggest that dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor.

In vivo:

Biol Pharm Bull. 2002 Jan;25(1):81-6.

Dehydrotrametenolic acid induces preadipocyte differentiation and sensitizes animal models of noninsulin-dependent diabetes mellitus to insulin.[Pubmed: 11824563]

We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos WOLF (Polyporaceae), a well-known traditional Chinese medicinal plant.
METHODS AND RESULTS:
We examined the effects of dehydrotrametenolic acid on plasma glucose concentration in obese hyperglycemic db/db mice. Dehydrotrametenolic acid can reduce hyperglycemia in mouse models of noninsulin-dependent diabetes mellitus (NIDDM) and act as an insulin sensitizer as indicated by the results of the glucose tolerance test. These terpenoids and thiazolidine type of antidiabetic agents such as Ciglitazone, although structurally unrelated, share many biological activities: both induce adipose conversion, activate peroxisome proliferator-activated receptor gamma (PPAR gamma) in vitro, and reduce hyperglycemia in animal models of NIDDM. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.
CONCLUSIONS:
This finding is very important for the development of insulin sensitizers that are not of the thiazolidine type.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3beta-羟基羊毛甾-8,24-二烯-21-醛; 3beta-Hydroxylanosta-8,24-diene-21-al	CFN92365	96574-03-7	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：2159513211
3β-羟基-羊毛甾-8,24-二烯-21-酸; Trametenolic acid	CFN92366	24160-36-9	C₃₀H₄₈O₃ = 456.7	10mg	QQ客服：1413575084
Tsugaric acid A; Tsugaric acid A	CFN90990	174391-64-1	C₃₂H₅₀O₄ = 498.8	5mg	QQ客服：215959384
榄香酮酸; Beta-Elemonic acid	CFN90991	28282-25-9	C₃₀H₄₆O₃ = 454.7	20mg	QQ客服：3257982914
16 alpha-Hydroxytrametenolic acid; 16 alpha-Hydroxytrametenolic acid	CFN90803	176390-68-4	C₃₀H₄₈O₄ = 472.7	5mg	QQ客服：2056216494
3-O-Acetyl-16 alpha-hydroxytrametenolic acid; 3-O-Acetyl-16 alpha-hydroxytrametenolic acid	CFN90804	168293-13-8	C₃₂H₅₀O₅ = 514.8	5mg	QQ客服：2159513211
松苓新酸; Dehydrotrametenolic acid	CFN90577	29220-16-4	C₃₀H₄₆O₃ = 454.69	20mg	QQ客服：2159513211
16α-羟基松苓新酸; 16alpha-Hydroxydehydrotrametenolic acid	CFN90790	176390-66-2	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：2159513211
3-O-乙酰基-16α-羟基松苓新酸; 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	CFN90791	168293-14-9	C₃₂H₄₈O₅ = 512.7	5mg	QQ客服：3257982914
茯苓酸B; Poricoic acid B	CFN95050	137551-39-4	C₃₀H₄₄O₅ = 484.7	20mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1993 mL	10.9965 mL	21.993 mL	43.986 mL	54.9825 mL
5 mM	0.4399 mL	2.1993 mL	4.3986 mL	8.7972 mL	10.9965 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL	4.3986 mL	5.4983 mL
50 mM	0.044 mL	0.2199 mL	0.4399 mL	0.8797 mL	1.0997 mL
100 mM	0.022 mL	0.11 mL	0.2199 mL	0.4399 mL	0.5498 mL

松苓新酸

Dehydrotrametenolic acid

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