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  • 达沙替尼

    Dasatinib (BMS-354825)

    达沙替尼
    产品编号 CFN60030
    CAS编号 302962-49-8
    分子式 = 分子量 C22H26ClN7O2S = 488.01
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    达沙替尼 CFN60030 302962-49-8 1mg QQ客服:215959384
    达沙替尼 CFN60030 302962-49-8 5mg QQ客服:215959384
    达沙替尼 CFN60030 302962-49-8 10mg QQ客服:215959384
    达沙替尼 CFN60030 302962-49-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Hydrocolloids2024, 152:109898
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • BioResources J.2020, 15(3).
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  • ...
  • 生物活性
    Description: Dasatinib (BMS-354825) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.
    Targets: Abl | Src | c-Kit | Autophagy
    In vitro:
    Clin Cancer Res,2012 Jul 1;18(13):3580-91.
    Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis.[Pubmed: 22586301]
    There are no effective therapies for patients with poorly differentiated papillary thyroid cancer (PTC) or anaplastic thyroid cancer (ATC), and metastasis to the bone represents a significantly worse prognosis. Src family kinases (SFKs) are overexpressed and activated in numerous tumor types and have emerged as a promising therapeutic target, especially in relation to metastasis. We recently showed that Src is overexpressed and activated in thyroid cancer. We therefore tested whether inhibition of Src with dasatinib (BMS-354825) blocks thyroid cancer growth and metastasis.
    METHODS AND RESULTS:
    The effects of dasatinib on thyroid cancer growth, signaling, cell cycle, and apoptosis were evaluated in vitro. The therapeutic efficacy of dasatinib was further tested in vivo using an orthotopic and a novel experimental metastasis model. Expression and activation of SFKs in thyroid cancer cells was characterized, and selectivity of dasatinib was determined using an Src gatekeeper mutant. Dasatinib treatment inhibited Src signaling, decreased growth, and induced cell-cycle arrest and apoptosis in a subset of thyroid cancer cells. Immunoblotting showed that c-Src and Lyn are expressed in thyroid cancer cells and that c-Src is the predominant SFK activated. Treatment with dasatinib blocked PTC tumor growth in an orthotopic model by more than 90% (P = 0.0014). Adjuvant and posttreatment approaches with dasatinib significantly inhibited metastasis (P = 0.016 and P = 0.004, respectively).
    CONCLUSIONS:
    These data provide the first evidence that Src is a central mediator of thyroid cancer growth and metastasis, indicating that Src inhibitors may have a higher therapeutic efficacy in thyroid cancer, as both antitumor and antimetastatic agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0491 mL 10.2457 mL 20.4914 mL 40.9828 mL 51.2285 mL
    5 mM 0.4098 mL 2.0491 mL 4.0983 mL 8.1966 mL 10.2457 mL
    10 mM 0.2049 mL 1.0246 mL 2.0491 mL 4.0983 mL 5.1228 mL
    50 mM 0.041 mL 0.2049 mL 0.4098 mL 0.8197 mL 1.0246 mL
    100 mM 0.0205 mL 0.1025 mL 0.2049 mL 0.4098 mL 0.5123 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Puerol A; Puerol A CFN96269 152784-32-2 C17H14O5 = 298.3 5mg QQ客服:2056216494
    TAK-632; TAK-632 CFN60274 1228591-30-7 C27H18F4N4O3S = 554.52 5mg QQ客服:2159513211
    Erastin; Erastin CFN60178 571203-78-6 C30H31ClN4O4 = 547.04 5mg QQ客服:1413575084
    甜菊醇-19-葡萄糖苷; Steviol-19-O-Glucoside CFN93339 1185737-16-9 C26H40O8 = 480.59 5mg QQ客服:2056216494

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