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  • 达玛烯二醇 II

    Dammarenediol II

    达玛烯二醇 II
    产品编号 CFN99476
    CAS编号 14351-29-2
    分子式 = 分子量 C30H52O2 = 444.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C.A.Mey.
    产品名称 产品编号 CAS编号 包装 QQ客服
    达玛烯二醇 II CFN99476 14351-29-2 1mg QQ客服:215959384
    达玛烯二醇 II CFN99476 14351-29-2 5mg QQ客服:215959384
    达玛烯二醇 II CFN99476 14351-29-2 10mg QQ客服:215959384
    达玛烯二醇 II CFN99476 14351-29-2 20mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • Universita' Degli Studi Di Cagliari (Italy)
  • Sant Gadge Baba Amravati University (India)
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  • Shanghai Institute of Organic Chemistry (China)
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  • Northeast Normal University Changchun (China)
  • Aveiro University (Portugal)
  • Center for protein Engineering (CIP) (Belgium)
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  • ...
  • 生物活性
    Description: Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber formation and vascular endothelial-cadherin disruption. The medicinally important dammarenediol II can be ectopically produced in tobacco, and the production of dammarenediol-II in tobacco plants allows them to adopt a viral defense system.
    Targets: VEGFR | Calcium Channel
    In vitro:
    Plant Cell Physiol. 2012 Jan;53(1):173-82.
    Dammarenediol-II production confers TMV tolerance in transgenic tobacco expressing Panax ginseng dammarenediol-II synthase.[Pubmed: 22102695]
    Panax ginseng is one of the famous medicinal plants. Ginsenosides, a class of tetracyclic triterpene saponins, are mainly responsible for its pharmacological activity. Most ginsenosides are composed of Dammarenediol II aglycone with various sugar moieties. Dammarenediol II synthase is the first enzyme in the biosynthesis of ginsenosides.
    Here, we report that transgenic tobacco expressing the P. ginseng Dammarenediol II synthase gene (PgDDS) produced Dammarenediol II, and conferred resistance to Tobacco mosaic virus (TMV). Upon infection with TMV, lesions developed more rapidly in transgenic tobacco plants, and their size was smaller than those of wild-type plants. Transgenic tobacco plants showed a low level of both the viral titer and mRNA accumulation of TMV coat protein (CP) compared with the wild type. The production of Dammarenediol II in transgenic tobacco stimulated the expression of tobacco pathogenesis-related genes (PR1 and PR2) under both virus-untreated and -treated conditions. When the leaves of wild-type plants were inoculated with a mixture of TMV and Dammarenediol II, the leaves exhibited a reduced viral concentration and TMV-CP expression than those receiving TMV treatment alone. When the leaves of P. ginseng were infected with TMV, transcription of PgDDS was significantly increased. Transgenic P. ginseng plants harboring a β-glucuronidase (GUS) gene driven by the PgDDS promoter were constructed. The GUS expression was activated when the transgenic ginseng plants were treated with TMV.
    These results indicate that the medicinally important Dammarenediol II can be ectopically produced in tobacco, and the production of Dammarenediol II in tobacco plants allows them to adopt a viral defense system.
    In vivo:
    Phytother Res. 2015 Dec;29(12):1910-6.
    Dammarenediol-II Prevents VEGF-Mediated Microvascular Permeability in Diabetic Mice.[Pubmed: 26400610]
    Diabetic retinopathy is a major diabetic complication predominantly caused by vascular endothelial growth factor (VEGF)-induced vascular permeability in the retina; however, treatments targeting glycemic control have not been successful.
    Here, we investigated the protective effect of Dammarenediol II, a precursor of triterpenoid saponin biosynthesis, on VEGF-induced vascular leakage using human umbilical vein endothelial cells (HUVECs) and diabetic mice. We overproduced the compound in transgenic tobacco expressing Panax ginseng Dammarenediol II synthase gene and purified using column chromatography. Analysis of the purified compound using a gas chromatography-mass spectrometry system revealed identical retention time and fragmentation pattern to those of authentic standard Dammarenediol II. Dammarenediol II inhibited VEGF-induced intracellular reactive oxygen species generation, but it had no effect on the levels of intracellular Ca(2+) in HUVECs. We also found that Dammarenediol II inhibited VEGF-induced stress fiber formation and vascular endothelial-cadherin disruption, both of which play critical roles in modulating endothelial permeability. Notably, microvascular leakage in the retina of diabetic mice was successfully inhibited by intravitreal Dammarenediol II injection.
    Our results suggest that the natural drug Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2487 mL 11.2435 mL 22.4871 mL 44.9741 mL 56.2177 mL
    5 mM 0.4497 mL 2.2487 mL 4.4974 mL 8.9948 mL 11.2435 mL
    10 mM 0.2249 mL 1.1244 mL 2.2487 mL 4.4974 mL 5.6218 mL
    50 mM 0.045 mL 0.2249 mL 0.4497 mL 0.8995 mL 1.1244 mL
    100 mM 0.0225 mL 0.1124 mL 0.2249 mL 0.4497 mL 0.5622 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    龙脑香醇酮; Dipterocarpol CFN98705 471-69-2 C30H50O2 = 442.7 5mg QQ客服:3257982914
    20,24-二羟基达玛-25-烯-3-酮; 20,24-Dihydroxydammar-25-en-3-one CFN97232 75069-59-9 C30H50O3 = 458.7 5mg QQ客服:1457312923
    (24S)-24,25-环氧达玛树脂-20-烯-3-酮; 24,25-Epoxydammar-20(21)-en-3-one CFN97092 63543-52-2 C30H48O2 = 440.7 5mg QQ客服:1413575084
    达玛树脂-20(21)-烯-3,24,25-三醇; Dammar-20(21)-en-3,24,25-triol CFN98922 55050-69-6 C30H52O3 = 460.7 5mg QQ客服:2056216494
    24,25-二羟基达马树脂-20-烯-3-酮; 24,25-Dihydroxydammar-20-en-3-one CFN97093 63543-53-3 C30H50O3 = 458.7 5mg QQ客服:2159513211
    25(R)-羟基原人参二醇; 25(R)-Hydroxyprotopanaxadiol CFN90349 83349-37-5 C30H54O4 = 478.75 5mg QQ客服:215959384
    25(S)-羟基原人参三醇; 25(S)-Hydroxyprotopanaxatriol CFN90351 113539-03-0 C30H54O5 = 494.75 5mg QQ客服:2056216494
    绞股蓝皂苷XLIX; Gypenoside XLIX CFN99717 94987-08-3 C52H86O21 = 1047.23 20mg QQ客服:2159513211
    芍药二酮; Palbinone CFN96019 139954-00-0 C22H30O4 = 358.5 5mg QQ客服:1413575084
    达玛烯二醇 II 3-O-咖啡酸酯; Dammarenediol II 3-O-caffeate CFN96254 171438-55-4 C39H58O5 = 606.9 5mg QQ客服:3257982914





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