盐酸野靛碱

Cytisine Hydrochloride

	产品编号	CFN80438
	CAS编号	6047-01-4
	分子式 = 分子量	C₁₁H₁₄N₂O.HCl = 226.70
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Genista tinctoria L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
盐酸野靛碱	CFN80438	6047-01-4	1mg	QQ客服：2159513211
盐酸野靛碱	CFN80438	6047-01-4	5mg	QQ客服：2159513211
盐酸野靛碱	CFN80438	6047-01-4	10mg	QQ客服：2159513211
盐酸野靛碱	CFN80438	6047-01-4	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Cancer Research Initatives Foundation(CARIF) (Malaysia)

University of Hawaii Cancer Center (USA)

Martin Luther University of Halle-Wittenberg (Germany)

University of Madras (India)

University of Illinois (USA)

University of Pretoria (South Africa)

Anna University (India)

Medical University of Gdansk (Poland)

Almansora University (Egypt)

Amity University (India)

University of Lodz (Poland)

Northeast Normal University Changchun (China)

Universidad Miguel Hernández (Spain)

Indian Institute of Science (India)

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Description:

Cytisine hydrochloride has toxicity.

In vivo:

Br J Pharmacol. 1969 Jan;35(1):161-74.

Some studies on cytisine and its methylated derivatives.[Pubmed: 4387392]

METHODS AND RESULTS:
1. In mice Cytisine Hydrochloride is less toxic intravenously than nicotine hydrogen tartrate, but more toxic by intraperitoneal or oral administration. Compared with cytisine, caulophylline hydrogen iodide is one-fifth to one-tenth as toxic and caulophylline methiodide is less than one-thirtieth as toxic.2. The surprising low oral toxicity of cytisine and nicotine may be ascribed to the method of administration; if the drug is placed directly in the stomach there is no possibility of absorption through buccal mucous membranes.3. The peripheral effects of nicotine, cytisine and caulophylline are similar, though on some preparations those of nicotine last longer. In most tests cytisine is active in doses from a quarter to three-quarters of those of nicotine, caulophylline in doses from 10 to 20 times those of cytisine. Caulophylline methiodide is virtually inactive.4. Cytisine and caulophylline may differ from nicotine in their central effects.5. Cytisine and caulophylline are active as the cations. The pKa of cytisine is 7.92 and that of caulophylline is 7.04; the difference accounts, in part, for the weaker activity of caulophylline. The caulophylline ion is generally one-sixth to one-third as active as the cytisine ion.6. The introduction of the second methyl group to form the quaternary salt does not appear to cause a dramatic change in the conformation of the molecule.
CONCLUSIONS:
Caulophylline methiodide appears to be feebly active because it has feeble affinity.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.4111 mL	22.0556 mL	44.1112 mL	88.2223 mL	110.2779 mL
5 mM	0.8822 mL	4.4111 mL	8.8222 mL	17.6445 mL	22.0556 mL
10 mM	0.4411 mL	2.2056 mL	4.4111 mL	8.8222 mL	11.0278 mL
50 mM	0.0882 mL	0.4411 mL	0.8822 mL	1.7644 mL	2.2056 mL
100 mM	0.0441 mL	0.2206 mL	0.4411 mL	0.8822 mL	1.1028 mL

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