环(苯丙氨酸-脯氨酸)二肽

Cyclo(Phe-Pro)

	产品编号	CFN90271
	CAS编号	14705-60-3
	分子式 = 分子量	C₁₄H₁₆N₂O₂ = 244.29
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	From Pantoea agglomerans
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
环(苯丙氨酸-脯氨酸)二肽	CFN90271	14705-60-3	1mg	QQ客服：1413575084
环(苯丙氨酸-脯氨酸)二肽	CFN90271	14705-60-3	5mg	QQ客服：1413575084
环(苯丙氨酸-脯氨酸)二肽	CFN90271	14705-60-3	10mg	QQ客服：1413575084
环(苯丙氨酸-脯氨酸)二肽	CFN90271	14705-60-3	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Cyclo(Phe-Pro) inhibition of cholera toxin and toxin-coregulated pilus production correlated with reduced transcription of the virulence regulator tcpPH and was alleviated by overexpression of tcpPH.Cyclo(Phe-Pro) has been shown to inhibit cancer cell growth and induce apoptosis in HT-29 colon cancer cells.

Targets:

PARP | Caspase | NF-kB | IkB | IKK

In vitro:

Anticancer Res. 2005 Nov-Dec;25(6B):4197-202.

Caspase-3 activation and induction of PARP cleavage by cyclic dipeptide cyclo(Phe-Pro) in HT-29 cells.[Pubmed: 16309216]

Cyclo(Phe-Pro) has been shown to inhibit cancer cell growth and induce apoptosis in HT-29 colon cancer cells.
METHODS AND RESULTS:
The molecular mechanisms mediating Cyclo(Phe-Pro)-induced apoptosis in HT-29 cells were investigated. Cells were treated with 5 mM or 10 mM Cyclo(Phe-Pro) for varying times. Immunoblot analysis was used to detect poly(ADP-ribose)polymerase (PARP) cleavage. A fluorescence-based enzymatic assay was used to measure caspase-3 activity.Cyclo(Phe-Pro) (10 mM) induced time-dependent cleavage of PARP, detected as early as 8 hours post treatment. PARP cleavage was blocked by co-administration with the broad-range caspase inhibitor Z-VAD-FMK Cyclo(Phe-Pro) also induced a time-dependent increase (p < 0.01) in caspase-3 activity. This increase in activity was blocked in the presence of the caspase-3 inhibitor Ac-DEVD-CHO.
CONCLUSIONS:
These results provide evidence that Cyclo(Phe-Pro)-induced apoptosis in HT-29 cells is mediated by a caspase cascade. These findings warrant further investigation into the potential antitumour activity of Cyclo(Phe-Pro) and its related cyclic dipeptide derivatives.

In vivo:

Infect Immun. 2015 Mar;83(3):1150-61.

Cyclo(Phe-Pro) produced by the human pathogen Vibrio vulnificus inhibits host innate immune responses through the NF-κB pathway.[Pubmed: 25561711]

Cyclo(Phe-Pro) (cFP) is a secondary metabolite produced by certain bacteria and fungi. Although recent studies highlight the role of Cyclo(Phe-Pro) in cell-to-cell communication by bacteria, its role in the context of the host immune response is poorly understood. In this study, we investigated the role of Cyclo(Phe-Pro) produced by the human pathogen Vibrio vulnificus in the modulation of innate immune responses toward the pathogen.
METHODS AND RESULTS:
Cyclo(Phe-Pro) suppressed the production of proinflammatory cytokines, nitric oxide, and reactive oxygen species in a lipopolysaccharide (LPS)-stimulated monocyte/macrophage cell line and in bone marrow-derived macrophages. Specifically, Cyclo(Phe-Pro) inhibited inhibitory κB (IκB) kinase (IKK) phosphorylation, IκBα degradation, and nuclear factor κB (NF-κB) translocation to the cell nucleus, indicating that Cyclo(Phe-Pro) affects the NF-κB pathway. We searched for genes that are responsible for Cyclo(Phe-Pro) production in V. vulnificus and identified VVMO6_03017 as a causative gene. A deletion of VVMO6_03017 diminished Cyclo(Phe-Pro) production and decreased virulence in subcutaneously inoculated mice.
CONCLUSIONS:
In summary, Cyclo(Phe-Pro) produced by V. vulnificus actively suppresses the innate immune responses of the host, thereby facilitating its survival and propagation in the host environment.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Astin C; Astin C	CFN95189	148057-23-2	C₂₅H₃₃N₅O₆Cl₂ = 570.5	10mg	QQ客服：2159513211
zeta-Clausenamide; zeta-Clausenamide	CFN95745	136173-85-8	C₁₈H₁₇NO₂ = 279.3	5mg	QQ客服：3257982914
环(D-苯丙氨酸-L-脯氨酸); Cyclo(D-Phe-L-Pro)	CFN96110	26488-24-4	C₁₄H₁₆N₂O₂ = 244.3	10mg	QQ客服：215959384
环(L-苯丙氨酸-L-脯氨酸)二肽; Cyclo(L-Phe-L-Pro)	CFN96129	3705-26-8	C₁₄H₁₆N₂O₂ = 244.3	10mg	QQ客服：1413575084
环(酪氨酸-脯氨酸)二肽; Cyclo(Tyr-Pro)	CFN90276	5654-84-2	C₁₄H₁₆N₂O₃ = 260.29	10mg	QQ客服：2159513211
环(酪氨酸-苯丙氨酸)二肽; Cyclo(Tyr-Phe)	CFN90278	5147-17-1	C₁₈H₁₈N₂O₃ = 310.35	10mg	QQ客服：3257982914
3,6-Dibenzyl-2-hydroxy-5-methoxypyrazine; 3,6-Dibenzyl-2-hydroxy-5-methoxypyrazine	CFN89034	132213-65-1	C₁₉H₁₈N₂O₂ = 306.36	5mg	QQ客服：2056216494
Emeheterone; Emeheterone	CFN96983	117333-12-7	C₁₉H₁₈N₂O₃ = 322.36	5mg	QQ客服：215959384
环(苯丙氨酸-羟脯氨酸)二肽; Cyclo(Phe-Hpro)	CFN90280	1016899-94-7	C₁₄H₁₆N₂O₃ = 260.30	10mg	QQ客服：3257982914
环(酪氨酸-羟脯氨酸)二肽; Cyclo(Tyr-Hpro)	CFN90279	813461-21-1	C₁₄H₁₆N₂O₄ = 276.29	10mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0935 mL	20.4675 mL	40.935 mL	81.8699 mL	102.3374 mL
5 mM	0.8187 mL	4.0935 mL	8.187 mL	16.374 mL	20.4675 mL
10 mM	0.4093 mL	2.0467 mL	4.0935 mL	8.187 mL	10.2337 mL
50 mM	0.0819 mL	0.4093 mL	0.8187 mL	1.6374 mL	2.0467 mL
100 mM	0.0409 mL	0.2047 mL	0.4093 mL	0.8187 mL	1.0234 mL

环(苯丙氨酸-脯氨酸)二肽

Cyclo(Phe-Pro)

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