二氢山芹醇醋酸酯

Columbianetin acetate

	产品编号	CFN90510
	CAS编号	23180-65-6
	分子式 = 分子量	C₁₆H₁₆O₅ = 288.30
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Angelica biserrata.
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产品名称	产品编号	CAS编号	包装	QQ客服
二氢山芹醇醋酸酯	CFN90510	23180-65-6	10mg	QQ客服：3257982914
二氢山芹醇醋酸酯	CFN90510	23180-65-6	20mg	QQ客服：3257982914
二氢山芹醇醋酸酯	CFN90510	23180-65-6	50mg	QQ客服：3257982914
二氢山芹醇醋酸酯	CFN90510	23180-65-6	100mg	QQ客服：3257982914

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Description:

Columbianetin may be helpful in regulating mast cell-mediated allergic inflammatory responses, the absorption of columbianetin acetate is a passive diffusion process without pH-dependent.

Targets:

Immunology & Inflammation related

In vitro:

Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6(4):392-8.

Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model[Pubmed: 18405608]

To study the absorption and transepithelial transport of six coumarins (umbelliferone, osthole, columbianadin, columbianetin acetate, angelol-A and angelol-B, isolated from the roots of Angelica pubescens f. biserrata) in the human Caco-2 cell monolayer model.
METHODS AND RESULTS:
The in vitro cultured human colon carcinoma cell line, Caco-2 cell monolayer model, was applied to study the absorption and transport of the six coumarins from apical (AP) to basolateral (BL) side and from BL to AP side. The six coumarins were measured by reversed-phase high-performance liquid chromatography (HPLC) coupled with ultraviolet absorption detector. Transport parameters and apparent permeability coefficients (P(app)) were calculated and compared with those of propranolol as a control substance of high permeability and atenolol as a control substance of poor permeability. The transport mechanism of angelol-B was assayed by using iodoacetamide as a reference standard to inhibit ATP-dependent transport and MK571 as a well-known inhibitor of MRP2. The absorption and transport of six coumarins were passive diffusion as the dominating process. The P(app) values of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol-A and angelol-B from AP to BL side were (2.679+/-0.263) x 10(-5), (1.306+/-0.324) x 10(-5), (0.595+/-0.086) x 10(-6), (2.930+/-0.410) x 10(-6), (1.532+/-0.444) x 10(-5) and (1.413+/-0.243) x 10(-5) cm/s, and from BL to AP side were (3.381+/-0.410) x 10(-5), (0.898+/-0.134) x 10(-5), (0.510+/-0.183) x 10(-6), (0.222+/-0.025) x 10(-6), (1.203+/-0.280) x 10(-5) and (0.754+/-0.092) x 10(-5) cm/s, respectively. In this assay, the P(app) value of propranolol was 2.18 x 10(-5) cm/s and the P(app) value of atenolol was 2.77 x 10(-7) cm/s. Among the 6 coumarins, the P(app) values of umbelliferone, osthole, angelol-A and angelol-B from AP to BL side were identical with that of propranolol, and columbianadin and columbianetin acetate lied between propranolol and atenolol. When replaced the HBSS with EBSS, and iodoacetamide or MK-591 were used in the experiment, the P(app) of angelol-B had no statistical difference as compared with the control group. In the mean total recoveries, umbelliferone was (83.31+/-3.52)%, angelol-A was (77.39+/-7.38)%, osthole, columbianadin and angelol-B were between 50% to 65%, and columbianetin acetate was lower than 10%. The accumulation rates of osthole and columbianadin in the Caco-2 cells were (36.15+/-5.87)% and (53.90+/-4.39)%, respectively.
CONCLUSIONS:
The absorption and transport of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol-A and angelol-B are passive diffusion as the dominating process in Caco-2 cell monolayer model. Umbelliferone, osthole, angelol-A and angelol-B are estimated to be highly absorbed compounds, and columbianadin and columbianetin acetate are estimated to be moderately absorbed compounds. In the Caco-2 cells, osthol and columbianadin appear to accumulate, and columbianetin acetate may be metabolized. The absorption and transport of angelol-B are not influenced by the change of pH and the presence of iodoacetamide or MK571.

In vivo:

Planta Med. 1995 Feb;61(1):2-8.

Anti-inflammatory and analgesic activities from roots of Angelica pubescens.[Pubmed: 7700984]

METHODS AND RESULTS:
In the present study, we extracted Angelica pubescens (AP) with various solvents in order to find the bioactive constituents that demonstrated analgesic and anti-inflammatory effects. The results were obtained as follows: (1) Methanol-, chloroform-, and ethyl acetate-extracts effectively reduced the pain that was induced by 1% acetic acid and a hot plate. (2) Methanol-, chloroform-, and ethyl acetate-extracts reduced the edema that was induced by 3% formalin or 1.5% carrageenan. (3) Sixteen compounds have been isolated and identified from the roots of AP. Among these compounds, columbianadin, columbianetin acetate, bergapten, umbelliferone, and caffeic acid significantly demonstrated anti-inflammatory and analgesic activities at 10 mg/kg. However, only osthole and xanthotoxin revealed anti-inflammatory activity. Isoimperatorin only demonstrated an analgesic effect.
CONCLUSIONS:
These results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central nervous system.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
山芹醇; Oroselol	CFN95001	1891-25-4	C₁₄H₁₂O₄ = 244.2	5mg	QQ客服：3257982914
二氢山芹醇; Columbianetin	CFN90185	3804-70-4	C₁₄H₁₄O₄ = 246.26	20mg	QQ客服：215959384
Angelidiol; Angelidiol	CFN92989	156009-77-7	C₁₄H₁₄O₅ = 262.26	5mg	QQ客服：3257982914
二氢山芹醇醋酸酯; Columbianetin acetate	CFN90510	23180-65-6	C₁₆H₁₆O₅ = 288.30	20mg	QQ客服：2159513211
二氢欧山芹醇当归酸酯; Columbianadin	CFN99785	5058-13-9	C₁₉H₂₀O₅ = 328.36	20mg	QQ客服：1413575084
二氢山芹醇 β-D-葡萄糖苷; Columbianetin beta-D-glucopyranoside	CFN95038	55836-35-6	C₂₀H₂₄O₉ = 408.4	5mg	QQ客服：2056216494
Apterin; Apterin	CFN95005	53947-89-0	C₂₀H₂₄O₁₀ = 424.4	10mg	QQ客服：3257982914
白花前胡定; Peucenidin	CFN95272	33044-93-8	C₂₁H₂₂O₇ = 386.4	5mg	QQ客服：215959384
异食用当归素; Isoedultin	CFN95273	43043-08-9	C₂₁H₂₂O₇ = 386.4	5mg	QQ客服：3257982914
9-羟基-O-异戊烯酰基-8,9-二氢山芹醇; 9-Hydroxy-O-senecioyl-8,9-dihydrooroselol	CFN95274	31456-63-0	C₁₉H₂₀O₆ = 344.4	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4686 mL	17.343 mL	34.6861 mL	69.3722 mL	86.7152 mL
5 mM	0.6937 mL	3.4686 mL	6.9372 mL	13.8744 mL	17.343 mL
10 mM	0.3469 mL	1.7343 mL	3.4686 mL	6.9372 mL	8.6715 mL
50 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.3874 mL	1.7343 mL
100 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.6937 mL	0.8672 mL

二氢山芹醇醋酸酯

Columbianetin acetate

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