蝶豆素

Clitorin

	产品编号	CFN93049
	CAS编号	55804-74-5
	分子式 = 分子量	C₃₃H₄₀O₁₉ = 740.66
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The leaves of Ginkgo biloba L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
蝶豆素	CFN93049	55804-74-5	1mg	QQ客服：3257982914
蝶豆素	CFN93049	55804-74-5	5mg	QQ客服：3257982914
蝶豆素	CFN93049	55804-74-5	10mg	QQ客服：3257982914
蝶豆素	CFN93049	55804-74-5	20mg	QQ客服：3257982914

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Description:

Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.

Targets:

PKC | Antifection

In vitro:

J Ethnopharmacol. 2014 Aug 8;155(1):426-34.

HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L.[Pubmed: 24892830 ]

Leaf decoctions of Carica papaya have been traditionally used in some parts of Indonesia to treat and prevent malaria. Leaf extracts and fraction have been previously shown to possess antiplasmodial activity in vitro and in vivo.
METHODS AND RESULTS:
Antiplasmodial activity of extracts was confirmed and the active fractions in the extract were identified by HPLC-based activity profiling, a gradient HPLC fractionation of a single injection of the extract, followed by offline bioassay of the obtained microfractions. For preparative isolation of compounds, an alkaloidal fraction was obtained via adsorption on cationic ion exchange resin. Active compounds were purified by HPLC-MS and MPLC-ELSD. Structures were established by HR-ESI-MS and NMR spectroscopy. For compounds 5 and 7 absolute configuration was confirmed by comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy data, and by X-ray crystallography. Compounds were tested for bioactivity in vitro against four parasites (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum), and in the Plasmodium berghei mouse model. Profiling indicated flavonoids and alkaloids in the active time windows. A total of nine compounds were isolated. Four were known flavonols--manghaslin, Clitorin, rutin, and nicotiflorin. Five compounds isolated from the alkaloidal fraction were piperidine alkaloids. Compounds 5 and 6 were inactive carpamic acid and methyl carpamate, while three alkaloids 7-9 showed high antiplasmodial activity and low cytotoxicity. When tested in the Plasmodium berghei mouse model, carpaine (7) did not increase the survival time of animals.
CONCLUSIONS:
The antiplasmodial activity of papaya leaves could be linked to alkaloids. Among these, carpaine was highly active and selective in vitro. The high in vitro activity could not be substantiated with the in vivo murine model. Further investigations are needed to clarify the divergence between our negative in vivo results for carpaine, and previous reports of in vivo activity with papaya leaf extracts.

In vivo:

Journal of Food Biochemistry, 2015,39(6):642–652.

In Vivo Anti-Hyperglycemic Potential of Brahmi Gritham and Docking Studies of Its Active Components Against Protein Kinase C and CD38[Reference: WebLink]

The anti-hyperglycemic and antioxidant effects of the Indian herbal formulation Brahmi gritham were studied in streptozotocin-induced diabetic female Wistar albino rats.
METHODS AND RESULTS:
Diabetes was induced by a single dose of streptozotocin (55 mg/kg body weight [b.w.], i.p.). Estimation of blood glucose levels, liver glycogen content and antioxidant levels were carried out in experimental rats. The tested parameters were compared with those of the glibenclamide (600 μg/kg b.w.) treated group. Molecular docking studies were carried out to analyze the interaction patterns of protein kinase C (PKC) and CD38 of chosen proteins of signal transduction pathways that are significant in the pathogenesis of diabetes against active components of Brahmi gritham. Immunohistochemistry of pancreas revealed that Brahmi gritham was able to restore β-cell mass and function near to that of the normal control. In silico studies showed that apigenin and quercetin showed significant interactions with PKC, while Clitorin, bacopaside I and II showed significant interactions with CD38. Quercetin showed highest percentage inhibition of α-amylase enzyme.Practical ApplicationsBrahmi gritham is a traditional polyherbal formulation used in Ayurveda to treat memory disorders. The individual components of this formulation are known to possess significant antioxidant properties and contain several biologically active compounds found to be effective in treating various disorders, including diabetes and obesity.
CONCLUSIONS:
The efficacy of Brahmi gritham in diabetes management has not yet been studied, and therefore, the present study provides insights into the anti-hyperglycemic potential of this formulation in rat model. In addition, the results of in silico analysis would pave way for better utilization of the flavonoids quercetin and apigenin in diabetes management and in particular microvascular diabetic complications.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3501 mL	6.7507 mL	13.5015 mL	27.0029 mL	33.7537 mL
5 mM	0.27 mL	1.3501 mL	2.7003 mL	5.4006 mL	6.7507 mL
10 mM	0.135 mL	0.6751 mL	1.3501 mL	2.7003 mL	3.3754 mL
50 mM	0.027 mL	0.135 mL	0.27 mL	0.5401 mL	0.6751 mL
100 mM	0.0135 mL	0.0675 mL	0.135 mL	0.27 mL	0.3375 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
芽子碱甲酯; Methylecgonine	CFN00190	7143-09-1	C₁₀H₁₇NO₃ = 199.25	5mg	QQ客服：3257982914
橐吾增碱; Ligularizine	CFN00379	90364-92-4	C₂₁H₂₉NO₈ = 423.46	5mg	QQ客服：2159513211
盐酸罂粟碱; Papaverine hydrochloride	CFN70483	61-25-6	C₂₀H₂₂ClNO₄ = 375.9	5mg	QQ客服：1413575084
紫铆因; Butein	CFN98776	487-52-5	C₁₅H₁₂O₅ = 272.3	20mg	QQ客服：215959384

蝶豆素

Clitorin

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