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  • Cinnamyl caffeate

    • Cinnamyl caffeate

    Cinnamyl caffeate

    Cinnamyl caffeate
    		产品编号 CFN89444
    CAS编号 115610-32-7
    分子式 = 分子量 C18H16O4 = 296.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 From Chinese propolis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Cinnamyl caffeate CFN89444 115610-32-7 1mg QQ客服：1457312923
    Cinnamyl caffeate CFN89444 115610-32-7 5mg QQ客服：1457312923
    Cinnamyl caffeate CFN89444 115610-32-7 10mg QQ客服：1457312923
    Cinnamyl caffeate CFN89444 115610-32-7 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Colorado State University (USA)
  • University of Limpopo (South Africa)
  • Universit?t Basel (Switzerland)
  • Sant Gadge Baba Amravati University (India)
  • Universidade Federal de Santa Catarina (Brazil)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Uniwersytet Gdański (Poland)
  • Korea Institute of Oriental Medicine (Korea)
  • Universite Libre de Bruxelles (Belgium)
  • University of Vigo (Spain)
  • University of Beira Interior (Portugal)
  • Heidelberg University (Germany)
  • Srinakharinwirot University (Thailand)
  • University Medical Center Mainz (Germany)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(11):E2102
  • Russian Journal of Bioorganic Chemistry2023, 49:1689–1698.
  • Molecules.2018, 23(10):E2638
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • PLoS One.2020, 15(2):e0220084.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Sci Rep.2019, 9(1):4646
  • Metabolites2023, 13(1), 3.
  • Front Pharmacol.2021, 12:762829.
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Int J Mol Sci.2022, 23(23):14545.
  • Agronomy2020, 10(3),388.
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Nat Commun.2019, 10(1):5169
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Molecules.2020, 25(18):4283.
  • Plant Physiol.2023, 193(3):1758-1771.
  • Inflammation.2022, 45(6):2529-2543.
  • Food Science and Human Wellness2022, 11(4):965-974
  • Metabolites.2020, 11(1):E11.
  • J Ethnopharmacol.2023, 317:116789.
  • Front Pharmacol.2022, 13:883475.
  • ...
    • 生物活性
    Description: Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level, and prevent cell apoptosis; it possesses potent antiproliferative activity with the EC(50) value of 0.114 microM, toward colon 26-L5 carcinoma. Cinnamyl caffeate possesses potent NO inhibitory activity with the IC(50) value of 9.53 microM.
    Targets: Calcium Channel | NO
    In vitro:
    Evid Based Complement Alternat Med. 2017;2017:7074147
    Potential Protective Effects of Bioactive Constituents from Chinese Propolis against Acute Oxidative Stress Induced by Hydrogen Peroxide in Cardiac H9c2 Cells.[Pubmed: 28337227 ]
    Chinese propolis (CP) is known as a health food but its beneficial effects in protecting cardiomyocytes remain elusive.
    METHODS AND RESULTS:
    Here, we investigated the effects of CP and its active compounds on hydrogen peroxide (H2O2) induced rats cardiomyocytes (H9c2) oxidative injury. Cell viability decreases induced by H2O2 were mitigated by different CP extracts using various solvents. From these active fractions, six active compounds were separated and identified. Among tested isolated compound, the cytoprotective activities of three caffeates, caffeic acid phenethyl ester (CAPE), benzyl caffeate (BZC), and Cinnamyl caffeate (CNC), exerted stronger effects than chrysin, pinobanksin, and 3,4-dimethoxycinnamic acid (DMCA). These three caffeates also increased H9c2 cellular antioxidant potential, decreased intracellular calcium ion ([Ca2+]i) level, and prevented cell apoptosis.
    CONCLUSIONS:
    Overall, the cardiovascular protective effects of the CP might be attributed to its caffeates constituents (CAPE, BZC, and CNC) and provide evidence for its usage in complementary and alternative medicine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3748 mL 16.8742 mL 33.7484 mL 67.4969 mL 84.3711 mL
    5 mM 0.675 mL 3.3748 mL 6.7497 mL 13.4994 mL 16.8742 mL
    10 mM 0.3375 mL 1.6874 mL 3.3748 mL 6.7497 mL 8.4371 mL
    50 mM 0.0675 mL 0.3375 mL 0.675 mL 1.3499 mL 1.6874 mL
    100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.675 mL 0.8437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参素钠; Sodium Danshensu CFN99163 67920-52-9 C9H9O5Na = 220.2 20mg QQ客服：3257982914
    左旋多巴; Levodopa CFN99800 59-92-7 C9H11NO4 = 197.20 20mg QQ客服：215959384
    Trans-咖啡酸; Trans-caffeic acid CFN92549 501-16-6 C9H8O4 = 180.2 20mg QQ客服：3257982914
    咖啡酸甲酯; Methyl caffeate acid CFN95561 3843-74-1 C10H10O4 = 194.18 5mg QQ客服：2056216494
    咖啡酸乙酯; Ethyl caffeate CFN97136 66648-50-8 C11H12O4 = 208.2 20mg QQ客服：1413575084
    咖啡酸苯乙酯; Caffeic acid phenethyl ester CFN90554 104594-70-9 C17H16O4 = 284.31 20mg QQ客服：3257982914
    Nepetoidin B; Nepetoidin B CFN96779 55486-06-1 C17H14O6 = 314.29 5mg QQ客服：1413575084
    Cinnamyl caffeate; Cinnamyl caffeate CFN89444 115610-32-7 C18H16O4 = 296.31 5mg QQ客服：1457312923
    香豆酸肉桂酯; Cinnamyl coumarate CFN89462 115610-30-5 C18H16O3 = 280.31 5mg QQ客服：3257982914
    (E)-Cinnamyl-(Z)-p-coumarate; (E)-Cinnamyl-(Z)-p-coumarate CFN89417 391682-51-2 C18H16O3 = 280.31 5mg QQ客服：215959384

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