Info: Read More
  • 中药标准品生产商,产品定制服务
  • 菊薁

    Chamazulene

    菊薁
    产品编号 CFN70396
    CAS编号 529-05-5
    分子式 = 分子量 C14H16 = 184.3
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The herbs of Matricaria chamomilla L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    菊薁 CFN70396 529-05-5 1mg QQ客服:2159513211
    菊薁 CFN70396 529-05-5 5mg QQ客服:2159513211
    菊薁 CFN70396 529-05-5 10mg QQ客服:2159513211
    菊薁 CFN70396 529-05-5 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Virginia (USA)
  • Universidade do Porto (Portugal)
  • University of Mysore (India)
  • Julius Kühn-Institut (Germany)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Parma (Italy)
  • Sapienza University of Rome (Italy)
  • Max Rubner-Institut (MRI) (Germany)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • National Chung Hsing University (Taiwan)
  • S.N.D.T. Women's University (India)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Toronto (Canada)
  • Monash University Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020, 25(21):5091.
  • Plants (Basel).2020, 9(11):1555.
  • Journal of Functional Foods2017, 30:30-38
  • Antioxidants (Basel).2021, 10(8):1300.
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Sci Rep.2021, 11(1):21038.
  • Agronomy2023, 13(9), 2410.
  • National Academy Science Letters2023, s40009.
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Molecules.2023, 28(8):3376.
  • Chemistry of Plant Materials.2019, 215-222
  • Metabolites.2019, 9(11):E271
  • Front Pharmacol.2022, 13:870553.
  • iScience.2020, 23(2):100849.
  • Nutr Res Pract2019, 13:e45
  • Acta Pharm Sin B.2024, 14(4):1772-1786.
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Int J Mol Sci.2023, 24(14):11496.
  • J Ginseng Res.2020, 44(4):611-618.
  • Reprod Sci.2022,10.1007/s43032-022-01117-4.
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Cell Prolif.2021, 54(8):e13083.
  • ...
  • 生物活性
    Description: Chamazulene is an important factor for the antioxidant power of chamomile oil, it presents interesting properties concerning radical processes. Chamazulene may contribute to the anti-inflammatory activity of chamomile extracts by inhibiting the leukotriene synthesis and additional antioxidative effects.
    In vitro:
    Planta medica, 1994, 60(05):410-413.
    Chamazulene: An Antioxidant-Type Inhibitor of Leukotriene B4 Formation.[Reference: WebLink]
    Matricine and its transformation product chamazulene are constituents of chamomile extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since preparations from chamomile are used for the treatment of inflammatory skin and bowel diseases, we studied the effects of these compounds on the leukotriene production in neutrophilic granulocytes.
    METHODS AND RESULTS:
    Chamazulene inhibited the formation of leukotriene B4 in intact cells and in the 105,000 × g supernatant fraction in a concentration-dependent manner. The IC50 values were 15 and 10 µM, respectively. Matricine showed no effect up to 200 µM. Chamazulene (IC50: 2 µM), but not matricine, blocked the chemical peroxidation of arachidonic acid. Additionally, matricine (up to 200 µM) had no effects on the cyclooxygenase and 12-lipoxygenase activities in human platelets.
    CONCLUSIONS:
    Therefore, it is concluded that chamazulene, but not matricine, may contribute to the anti-inflammatory activity of chamomile extracts by inhibiting the leukotriene synthesis and additional antioxidative effects.
    Research Communications in Molecular Pathology & Pharmacology, 1996, 92(3):361-364.
    Investigation of the effect of chamazulene on lipid peroxidation and free radical processes.[Reference: WebLink]
    Oxygen toxicity and related free radical reactions are implicated in numerous pathophysiological conditions, like atherosclerosis, inflammation, gastric ulceration, neuronal degeneration, tumour promotion. The flowers of Matricaria chamomilla, Asteraceae, have been used therapeutically for conditions in which oxidative stress is supposed to be implicated.
    METHODS AND RESULTS:
    We considered interesting to investigate the effect of Chamazulene, the active substance of chamomile, on free radical processes. Membrane lipid peroxidation was induced by Fe2+/ascorbate and assessed as the 2-thiobarbituric acid reactive material. The hydroxyl radical scavenging activity was studied as the competition of Chamazulene with DMSO for HO. generated by Fe3+/ascorbate. Finally, the interaction of Chamazulene with the N-centered stable free radical DPPH was estimated photometrically (517 nm). It was found that Chamazulene inhibited lipid peroxidation in a concentration and time dependent manner presenting an IC50 of 18 microM after 45 min incubation. It could also inhibit the autoxidation of DMSO (33 mM) by 76% at 25 mM, and had a weak capacity to interact with DPPH.
    CONCLUSIONS:
    In conclusion, Chamazulene presents interesting properties concerning radical processes.
    Natural Product Research,2014, 28(24):2321-2323.
    Antioxidant and radical scavenging activities of chamazulene.[Reference: WebLink]
    Essential oils (EOs) of chamomile contain several bioactive compounds, including monoterpenes, sesquiterpenes, triterpenes and fatty acids. Hydrodistillation of chamomile EO induces the formation of chamazulene, a bioactive compound.
    METHODS AND RESULTS:
    Chamazulene was isolated from the EO by column chromatography. The total antioxidant capacity confirmed a higher antioxidant activity of chamazulene (IC50 = 6.4 μg mL(- 1)) than of ascorbic acid (IC50 = 12.8 μg mL(- 1)), α-tocopherol (IC50 = 20.5 μg mL(- 1)) and of butylated hydroxytoluene (BHT) (IC50 = 30.8 μg mL(- 1)). Chamazulene was unable to react with DPPH√. However, when chamazulene was assayed with ABTS√, a strong and significantly (P < 0.05) higher free radical scavenging activity was observed (IC50 = 3.7 μg mL(- 1)), with respect to BHT (IC50 = 6.2 μg mL(- 1)) and α-tocopherol (IC50 = 11.5 μg mL(- 1)).
    CONCLUSIONS:
    The results of this work show that chamazulene is an important factor for the antioxidant power of chamomile oil.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.4259 mL 27.1297 mL 54.2594 mL 108.5187 mL 135.6484 mL
    5 mM 1.0852 mL 5.4259 mL 10.8519 mL 21.7037 mL 27.1297 mL
    10 mM 0.5426 mL 2.713 mL 5.4259 mL 10.8519 mL 13.5648 mL
    50 mM 0.1085 mL 0.5426 mL 1.0852 mL 2.1704 mL 2.713 mL
    100 mM 0.0543 mL 0.2713 mL 0.5426 mL 1.0852 mL 1.3565 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Cimiracemoside D; Cimiracemoside D CFN90649 290821-39-5 C37H58O11 = 678.39 10mg QQ客服:215959384
    鸦胆苦内酯C; Yadanziolide C CFN96426 95258-12-1 C20H26O9 = 410.41 5mg QQ客服:1457312923
    Albatrelin C; Albatrelin C CFN89310 1417805-17-4 C22H30O2 = 326.48 5mg QQ客服:215959384
    苹果酸 4-甲酯; Malic acid 4-Me ester CFN97130 66178-02-7 C5H8O5 = 148.1 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产