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  • 咖啡酸

    Caffeic acid

    咖啡酸
    产品编号 CFN99190
    CAS编号 331-39-5
    分子式 = 分子量 C9H8O4 = 180.15
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Boehmeria siamensis Craib.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    咖啡酸 CFN99190 331-39-5 10mg QQ客服:2159513211
    咖啡酸 CFN99190 331-39-5 20mg QQ客服:2159513211
    咖啡酸 CFN99190 331-39-5 50mg QQ客服:2159513211
    咖啡酸 CFN99190 331-39-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Otago (New Zealand)
  • Gyeongsang National University (Korea)
  • Copenhagen University (Denmark)
  • Monash University (Australia)
  • University of East Anglia (United Kingdom)
  • Seoul National University of Science and Technology (Korea)
  • University of Auckland (New Zealand)
  • Anna University (India)
  • University of Illinois (USA)
  • Wageningen University (Netherlands)
  • University of Melbourne (Australia)
  • S.N.D.T. Women's University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Eur J Pharmacol.2018, 832:96-103
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Phytomedicine.2018, 38:45-56
  • Food Funct.2020, 11(2):1322-1333.
  • Phytomedicine.2022, 99:153997.
  • J Cell Biochem.2018, 119(2):2231-2239
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Pharmacognosy Magazine2017, 13(52):868-874
  • J.the Korean Socie. Food Sci.&Nut.2023; 52(1):26-39.
  • Pharmaceutics.2022, 14(3):564.
  • Clin Transl Oncol.2019, 10.1007
  • Nutrients.2023, 15(4):954.
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • Bulletin of Health Research2016, 44(4):279-286
  • Food Res Int.2017, 96:40-45
  • Planta Med.2016, 82(13):1208-16
  • Journal of Analytical Chemistry2017, 854-861
  • Antioxidants (Basel).2021, 10(11):1831.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Phytochemistry.2017, 141:162-170
  • GxABT2022, 2268.2:15515.
  • University of Stuttgart2021, 11682.
  • Pharm Biol.2021, 59(1):134-145.
  • ...
  • 生物活性
    Description: Caffeic acid has antidiabetic, antioxidant, anticarcinogenic, and anti-inflammatory activities, it can suppress ultraviolet B(UVB)-induced COX-2 expression by blocking Fyn kinase activity, inhibits HBV-DNA replication as well as HBsAg production, also reduces serum DHBV level in DHBV-infected duckling model. Caffeic acid may be used as designed novel therapeutic drugs for Parkinson's disease by inhibiting α-synuclein fibrillation.
    Targets: Estrogen receptor | IGF-1R | HBV | AP-1 | COX | MAPK | NF-kB | NO | NOS | IL Receptor | Progestogen receptor
    In vitro:
    Antiviral Res. 2009 Aug;83(2):186-90.
    Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.[Pubmed: 19463857 ]
    Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity.
    METHODS AND RESULTS:
    In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied.
    CONCLUSIONS:
    Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
    2015 Sep 5;762:313-21
    Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice[Pubmed: 26057691]
    Itch is an unpleasant sensation that evokes a desire to scratch. Although often regarded as a trivial 'alarming' sensation, itch may be debilitating and exhausting, leading to reduction in quality of life. In the current study, the question of whether caffeic acid can be used to alleviate itch sensation induced by various pruritic agents, including histamine, chloroquine, SLIGRL-NH2, and β-alanine was investigated. It turned out that histamine-induced intracellular calcium increase was significantly blocked by caffeic acid in HEK293T cells that express H1R and TRPV1, molecules required for transmission of histamine-induced itch in sensory neurons. In addition, inhibition of histamine-induced intracellular calcium increase by caffeic acid was demonstrated in primary cultures of mouse dorsal root ganglion (DRG). When chloroquine, an anti-malaria agent known to induce histamine-independent itch - was used, it was also found that caffeic acid inhibits the induced response in both DRG and HEK293T cells that express MRGPRA3 and TRPA1, underlying molecular entities responsible for chloroquine-mediated itch. Likewise, intracellular calcium changes by SLIGRL-NH2 - an itch-inducing agent via PAR2 and MRGPRC11 - were decreased by caffeic acid as well. However, it was found that caffeic acid is not capable of inhibiting β-alanine-induced responses via its specific receptor MRGPRD. Finally, in vivo scratching behavior tests showed that caffeic acid indeed has anti-scratching effects against histamine, chloroquine, and SLIGRL-NH2 administration but not by β-alanine. Overall, the current study demonstrated that caffeic acid has anti-itch effects by inhibition of multiple itch mechanisms induced by histamine, chloroquine and SLIGRL-NH2.
    In vivo:
    J Pharmacol Exp Ther. 2006 Aug;318(2):476-83
    Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice.[Pubmed: 16644902 ]
    This study investigated the blood glucose-lowering effect and antioxidant capacity of caffeic acid in C57BL/KsJ-db/db mice.
    METHODS AND RESULTS:
    Caffeic acid induced a significant reduction of the blood glucose and glycosylated hemoglobin levels than the control group. The plasma insulin, C-peptide, and leptin levels in caffeic acid group were significantly higher than those of the control group, whereas the plasma glucagon level was lower. Increased plasma insulin by caffeic acid was attributable to an antidegenerative effect on the islets. Caffeic acid also markedly increased glucokinase activity and its mRNA expression and glycogen content and simultaneously lowered glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities and their respective mRNA expressions, accompanied by a reduction in the glucose transporter 2 expression in the liver. In contrast to the hepatic glucose transporter 2, adipocyte glucose transporter 4 expression was greater than the control group. In addition, caffeic acid significantly increased superoxide dismutase, catalase, and glutathione peroxidase activities and their respective mRNA levels, while lowering the hydrogen peroxide and thiobarbituric acid reactive substances levels in the erythrocyte and liver of db/db mice.
    CONCLUSIONS:
    These results indicate that caffeic acid exhibits a significant potential as an antidiabetic agent by suppressing a progression of type 2 diabetic states that is suggested by an attenuation of hepatic glucose output and enhancement of adipocyte glucose uptake, insulin secretion, and antioxidant capacity.
    Free Radic Res. 2004 Nov;38(11):1241-53.
    Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties.[Pubmed: 15621702]
    Caffeic acid and some of its derivatives such as caffeic acid phenetyl ester (CAPE) and octyl caffeate are potent antioxidants which present important anti-inflammatory actions.
    METHODS AND RESULTS:
    The present study assessed the in vitro and in vivo effects of five caffeic acid derivatives (caffeic acid methyl, ethyl, butyl, octyl and benzyl esters) and compared their actions to those of CAPE. In the model of LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages, the pre-incubation of all derivatives inhibited nitrite accumulation on the supernatant of stimulated cells, with mean IC50 (microM) values of 21.0, 12.0, 8.4, 2.4, 10.7 and 4.80 for methyl, ethyl, butyl, octyl, benzyl and CAPE, respectively. The effects of caffeic acid derivatives seem to be related to the scavenging of NO, as the compounds prevented SNAP-derived nitrite accumulation and decreased iNOS expression. In addition, butyl, octyl and CAPE derivatives significantly inhibited LPS-induced iNOS expression in RAW 264.7 macrophages. Extending the in vitro results, we showed that the pre-treatment of mice with butyl, octyl and CAPE derivatives inhibited carrageenan-induced paw edema and prevented the increase in IL-1beta levels in the mouse paw by 30, 24 and 36%, respectively. Butyl, octyl and CAPE derivatives also prevented carrageenan-induced neutrophil influx in the mouse paw by 28, 49 and 31%, respectively.
    CONCLUSIONS:
    Present results confirm and extend literature data, showing that caffeic acid derivatives exert in vitro and in vivo anti-inflammatory actions, being their actions mediated, at least in part by the scavenging of NO and their ability to modulate iNOS expression and probably that of other inflammatory mediators.
    2015 Apr 18;11:18.
    The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats[Pubmed: 25907417]
    Ischemic stroke is a major cause of death and disability all over the world. Ischemic stroke results from a temporary or permanent reduction of cerebral blood flow that leads to functional and structural damage in different brain regions. Despite decades of intense research, the beneficial treatment of stroke remains limited. In light of this, the search for effective means ameliorating cerebral ischemia-reperfusion injury (CIRI) is one of the major problems of experimental medicine and biology. Recently, the 5-Lipoxygenase (5-LO, a key enzyme metabolizing arachidonic acid to produce leukotrienes) inhibitors have been showed to protect brain against ischemic damage in animal model of cerebral ischemia. Caffeic acid, an inhibitor of 5-LO, is a phenolic compound widely distributed in medicinal plants. The aim of this study was to investigate the effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. The study was carried out on 45 rats that were randomly divided into five groups: the sham group (n = 9), I/R non-treated group (n = 9), I/R-caffeic acid group (10 mg · kg(-1)) (n = 9), I/R-caffeic acid group (30 mg · kg(-1)) (n = 9) and I/R-caffeic acid group (50 mg · kg(-1)) (n = 9). Global cerebral ischemia was induced by bilateral carotid artery occlusion for 20 min followed by reperfusion. Spatial learning and memory was evaluated using Morris water maze. Histopathological changes of hippocampus neurons was observed using HE staining. Superoxide dismutase (SOD, the antioxidant enzyme) activities and malondialdehyde (MDA, an oxidative stress biomarker) contents were detected. NF-κBp65 expression was detected by the methods of immunohistochemistry. Caffeic acid markedly reduced the escape latency, relieved hippocampal neurons injury and increased neuron count compared with those of I/R non-treated rat. NF-κBp65 expression and MDA content decreased significantly, and SOD activities increased significantly in hippocampus. Compared with sham group, 5-LO expression increase significantly in I/R non-treated group rat, and caffeic acid markedly reduced 5-LO expression. The results of the study suggest that caffeic acid has a significant protective effect on global cerebral ischemia-reperfusion injury in rats. The neuroprotective effects is likely to be mediated through the inhibition of 5-LO.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.5509 mL 27.7546 mL 55.5093 mL 111.0186 mL 138.7732 mL
    5 mM 1.1102 mL 5.5509 mL 11.1019 mL 22.2037 mL 27.7546 mL
    10 mM 0.5551 mL 2.7755 mL 5.5509 mL 11.1019 mL 13.8773 mL
    50 mM 0.111 mL 0.5551 mL 1.1102 mL 2.2204 mL 2.7755 mL
    100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Dactolisib (BEZ235) ; Dactolisib (BEZ235) CFN60056 915019-65-7 C30H23N5O = 469.55 5mg QQ客服:2159513211
    异绿原酸A; Isochlorogenic acid A CFN99118 2450-53-5 C25H24O12 = 516.45 20mg QQ客服:1413575084
    木犀草素-7-二葡萄糖苷酸; Luteolin 7-diglucuronide CFN70468 96400-45-2 C27H26O18 = 638.5 5mg QQ客服:1413575084
    Nardoaristolone B; Nardoaristolone B CFN95203 1422517-82-5 C14H18O2 = 218.3 5mg QQ客服:2159513211

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