贝韦立马

Bevirimat

	产品编号	CFN93106
	CAS编号	174022-42-5
	分子式 = 分子量	C₃₆H₅₆O₆ = 584.83
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Ziziphus jujuba
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
贝韦立马	CFN93106	174022-42-5	1mg	QQ客服：1413575084
贝韦立马	CFN93106	174022-42-5	5mg	QQ客服：1413575084
贝韦立马	CFN93106	174022-42-5	10mg	QQ客服：1413575084
贝韦立马	CFN93106	174022-42-5	20mg	QQ客服：1413575084

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sant Gadge Baba Amravati University (India)

Seoul National University of Science and Technology (Korea)

Uniwersytet Medyczny w ?odzi (Poland)

University of Hertfordshire (United Kingdom)

Universitas Airlangga (Indonesia)

Complutense University of Madrid (Spain)

Institute of Chinese Materia Medica (China)

University of Eastern Finland (Finland)

University of Beira Interior (Portugal)

Harvard University (USA)

Vin?a Institute of Nuclear Sciences (Serbia)

Copenhagen University (Denmark)

Universiti Kebangsaan Malaysia (Malaysia)

Wageningen University (Netherlands)

More...

Description:

Bevirimat is a HIV-1 maturation inhibitor.

Targets:

HIV

In vivo:

Antimicrob Agents Chemother. 2007 Sep;51(9):3063-6.

Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers.[Pubmed: 17576843 ]

Bevirimat (BVM; formerly known as PA-457) is a novel inhibitor of human immunodeficiency virus (HIV) maturation that is being developed for the treatment of HIV infection.
METHODS AND RESULTS:
The pharmacokinetics of this agent in healthy male volunteers were studied in a randomized, double-blind study in which the participants received single oral doses of placebo (n = 8) or escalating doses of BVM at 25, 50, 100, or 250 mg (n = 6 per dose); escalation was performed only after the pharmacokinetics and safety of the preceding dose had been evaluated. Plasma was collected over 480 h after dosing and urine was collected over 48 h after dosing for determination of the values of pharmacokinetic parameters. BVM was well absorbed after oral administration, with peak plasma concentrations being achieved 1 to 3 h after dosing. The half-life was 60 to 80 h. The exposure assessed by determination of the peak concentration and the area under the concentration-time curve was dose proportional. Single oral doses of BVM were well tolerated: there were no dose-limiting toxicities, and no serious adverse events were reported.
CONCLUSIONS:
These findings suggest that that BVM offers a favorable pharmacokinetic profile, with predictable pharmacokinetics following the oral administration of single doses. The long half-life of BVM may facilitate once-daily dosing.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
奥斯替尼; Osimertinib (AZD9291)	CFN60119	1421373-65-0	C₂₈ H₃₃ N₇ O₂ = 499.61	5mg	QQ客服：1457312923
达卡他韦; Daclatasvir (BMS-790052)	CFN60069	1009119-64-5	C₄₀H₅₀N₈O₆ = 738.88	5mg	QQ客服：2159513211
2,3-二羟基金松双黄酮; 2,3-dihydrosciadopitysin	CFN96134	34421-19-7	C₃₃H₂₆O₁₀ = 582.6	5mg	QQ客服：1413575084
双氢芝麻脂素; Dihydrosesamin	CFN96323	83708-70-7	C₂₀H₂₀O₆ = 356.4	5mg	QQ客服：3257982914

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7099 mL	8.5495 mL	17.099 mL	34.198 mL	42.7475 mL
5 mM	0.342 mL	1.7099 mL	3.4198 mL	6.8396 mL	8.5495 mL
10 mM	0.171 mL	0.8549 mL	1.7099 mL	3.4198 mL	4.2747 mL
50 mM	0.0342 mL	0.171 mL	0.342 mL	0.684 mL	0.8549 mL
100 mM	0.0171 mL	0.0855 mL	0.171 mL	0.342 mL	0.4275 mL