贝韦立马
Bevirimat
|
|
产品编号 |
CFN93106 |
| CAS编号 |
174022-42-5 |
| 分子式 = 分子量 |
C36H56O6 = 584.83 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Triterpenoids |
| 植物来源 |
The herbs of Ziziphus jujuba |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 贝韦立马 |
CFN93106 |
174022-42-5 |
1mg |
QQ客服：2056216494 |
| 贝韦立马 |
CFN93106 |
174022-42-5 |
5mg |
QQ客服：2056216494 |
| 贝韦立马 |
CFN93106 |
174022-42-5 |
10mg |
QQ客服：2056216494 |
| 贝韦立马 |
CFN93106 |
174022-42-5 |
20mg |
QQ客服：2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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Heidelberg University (Germany)
Max Rubner-Institut (MRI) (Germany)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Universitas islam negeri Jakarta (Indonesia)
Universidad Miguel Hernández (Spain)
FORTH-IMBB (Greece)
Instituto de Investigaciones Agropecuarias (Chile)
Julius Kühn-Institut (Germany)
University of the Basque Country (Spain)
Florida A&M University (USA)
University of Padjajaran (Indonesia)
University of Medicine and Pharmacy (Romania)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Bevirimat is a HIV-1 maturation inhibitor. |
| Targets: |
HIV |
| In vivo: |
| Antimicrob Agents Chemother. 2007 Sep;51(9):3063-6. | | Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers.[Pubmed: 17576843 ] | Bevirimat (BVM; formerly known as PA-457) is a novel inhibitor of human immunodeficiency virus (HIV) maturation that is being developed for the treatment of HIV infection.
METHODS AND RESULTS:
The pharmacokinetics of this agent in healthy male volunteers were studied in a randomized, double-blind study in which the participants received single oral doses of placebo (n = 8) or escalating doses of BVM at 25, 50, 100, or 250 mg (n = 6 per dose); escalation was performed only after the pharmacokinetics and safety of the preceding dose had been evaluated. Plasma was collected over 480 h after dosing and urine was collected over 48 h after dosing for determination of the values of pharmacokinetic parameters. BVM was well absorbed after oral administration, with peak plasma concentrations being achieved 1 to 3 h after dosing. The half-life was 60 to 80 h. The exposure assessed by determination of the peak concentration and the area under the concentration-time curve was dose proportional. Single oral doses of BVM were well tolerated: there were no dose-limiting toxicities, and no serious adverse events were reported.
CONCLUSIONS:
These findings suggest that that BVM offers a favorable pharmacokinetic profile, with predictable pharmacokinetics following the oral administration of single doses. The long half-life of BVM may facilitate once-daily dosing. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.7099 mL |
8.5495 mL |
17.099 mL |
34.198 mL |
42.7475 mL |
| 5 mM |
0.342 mL |
1.7099 mL |
3.4198 mL |
6.8396 mL |
8.5495 mL |
| 10 mM |
0.171 mL |
0.8549 mL |
1.7099 mL |
3.4198 mL |
4.2747 mL |
| 50 mM |
0.0342 mL |
0.171 mL |
0.342 mL |
0.684 mL |
0.8549 mL |
| 100 mM |
0.0171 mL |
0.0855 mL |
0.171 mL |
0.342 mL |
0.4275 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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