| Description: |
Benzaldehyde is an insecticidal, antimicrobial, and antioxidant compound, it could be applicable for developing novel insecticide for agriculture use. Oral Benzaldehyde exerts antiallergic effects in murine allergic asthma and rhinitis, possibly through inhibition of HIF-1α and VEGF. |
| Targets: |
Bcl-2/Bax | Caspase | IL Receptor | COX | SOD | HO-1 | HIF | VEGFR |
| In vitro: |
| J Microbiol. 2015 Feb;53(2):127-33. | | Benzaldehyde as an insecticidal, antimicrobial, and antioxidant compound produced by Photorhabdus temperata M1021.[Pubmed: 25626368 ] |
METHODS AND RESULTS:
The analysis of (1)H and (13)C NMR spectra revealed the identity of pure compound as "Benzaldehyde". The Benzaldehyde showed insecticidal activity against G. mellonella in a dose-dependent manner and 100% insect mortality was observed at 108 h after injection of 8 mM Benzaldehyde. In a PO inhibition assay, 4, 6, and 8 mM concentrations of Benzaldehyde were found to inhibit PO activity about 15%, 42%, and 80% respectively. In addition, nodule formation was significantly (P < 0.05) inhibited by 4, 6, and 8 mM of Benzaldehyde as compare to control. Moreover, Benzaldehyde was found to have great antioxidant activity and maximum antioxidant activity was 52.9% at 8 mM Benzaldehyde as compare to control.
Antimicrobial activity was assessed by MIC values ranged from 6 mM 10 mM for bacterial strains and 8 mM to 10 mM for fungal strains.
CONCLUSIONS:
The results suggest that Benzaldehyde could be applicable for developing novel insecticide for agriculture use. |
|
| In vivo: |
| Int Immunopharmacol. 2014 Oct;22(2):444-50. | | Benzaldehyde suppresses murine allergic asthma and rhinitis.[Pubmed: 25107441] |
METHODS AND RESULTS:
To evaluate the antiallergic effects of oral Benzaldehyde in a murine model of allergic asthma and rhinitis, we divided 20 female BALB/c mice aged 8-10 weeks into nonallergic (intraperitoneally sensitized and intranasally challenged to normal saline), allergic (intraperitoneally sensitized and intranasally challenged to ovalbumin), and 200- and 400-mg/kg Benzaldehyde (allergic but treated) groups. The number of nose-scratching events in 10 min, levels of total and ovalbumin-specific IgE in serum, differential counts of inflammatory cells in bronchoalveolar lavage (BAL) fluid, titers of Th2 cytokines (IL-4, IL-5, IL-13) in BAL fluid, histopathologic findings of lung and nasal tissues, and expressions of proteins involved in apoptosis (Bcl-2, Bax, caspase-3), inflammation (COX-2), antioxidation (extracellular SOD, HO-1), and hypoxia (HIF-1α, VEGF) in lung tissue were evaluated. The treated mice had significantly fewer nose-scratching events, less inflammatory cell infiltration in lung and nasal tissues, and lower HIF-1α and VEGF expressions in lung tissue than the allergic group. The number of eosinophils and neutrophils and Th2 cytokine titers in BAL fluid significantly decreased after the treatment (P<0.05).
CONCLUSIONS:
These results imply that oral Benzaldehyde exerts antiallergic effects in murine allergic asthma and rhinitis, possibly through inhibition of HIF-1α and VEGF. |
|
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