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  • BI 2536

    BI 2536

    BI 2536
    产品编号 CFN60044
    CAS编号 755038-02-9
    分子式 = 分子量 C28H39N7O3 = 521.66
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    BI 2536 CFN60044 755038-02-9 1mg QQ客服:1457312923
    BI 2536 CFN60044 755038-02-9 5mg QQ客服:1457312923
    BI 2536 CFN60044 755038-02-9 10mg QQ客服:1457312923
    BI 2536 CFN60044 755038-02-9 20mg QQ客服:1457312923
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hertfordshire (United Kingdom)
  • Hamdard University (India)
  • Universidade do Porto (Portugal)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Korea Food Research Institute(KFRI) (Korea)
  • Sapienza University of Rome (Italy)
  • University of Vienna (Austria)
  • Chiang Mai University (Thailand)
  • University of Liège (Belgium)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Texas A&M University (USA)
  • University of Lodz (Poland)
  • University of Pretoria (South Africa)
  • Universidad de Antioquia (Colombia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2020, 9(11):1555.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Neuropharmacology.2018, 131:68-82
  • Food and Chemical Toxicology2020, 111221
  • Phytother Res.2019, 33(7):1784-1793
  • Pharmacia2024, 71:1-9.
  • Anticancer Res.2018, 38(4):2127-2135
  • Am J Chin Med.2016, 44(8):1719-1735
  • Research Square2021, 10.21203.
  • Hortic Res.2023, 10(9):uhad154.
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Sci Rep. 2024, 14(1):70.
  • Daru.2022, 30(2):273-288.
  • J Inflamm Res.2022, 15:5347-5359.
  • Sustainability2021, 13(23),12981.
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Sains Malaysiana2022, 51(4):1143-1154
  • Enzyme Microb Technol.2022, 153:109941.
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Food and Fermentation Industries2018, 44(371)
  • Molecules.2022, 27(7):2093.
  • Front Pharmacol.2021, 12:690113.
  • Ecol Evol.2022, 12(11):e9459.
  • ...
  • 生物活性
    Description: BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy.
    Targets: Plk1 | c-Myc | Autophagy
    In vitro:
    Cancer Res,2009 Mar 1;69(5):1916-23.
    Identification of Polo-like kinase 1 as a potential therapeutic target in anaplastic thyroid carcinoma.[Pubmed: 19223553]
    Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and chemoresistant cancers. The serine/threonine kinase Polo-like kinase 1 (PLK1), a key regulator of multiple steps during mitotic progression, is highly expressed in ATC.
    METHODS AND RESULTS:
    Here, we used the BI 2536 PLK1 inhibitor on ATC and nontransformed thyroid follicular cell lines. Our data show that ATC cells are addicted to high levels of PLK1 activity for proliferation, survival, anchorage-independent growth, and tumorigenicity. On treatment with nanomolar doses of BI 2536, ATC cells progressed normally through S phase but died thereafter, directly from mitotic arrest. Immunofluorescence microscopy, immunoblot, and flow cytometry analysis showed that, on PLK1 blockade, ATC cells arrested in prometaphase with a 4N DNA content. Treated ATC cells accumulated phosphohistone H3 and displayed characteristic mitotic (Polo) spindle aberrations. Nontransformed thyroid cells were 3.2- to 18.4-fold less susceptible to BI 2536-induced cell cycle effects compared with ATC cells.
    CONCLUSIONS:
    These findings identify PLK1 as a promising target for the molecular therapy of ATC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.917 mL 9.5848 mL 19.1696 mL 38.3391 mL 47.9239 mL
    5 mM 0.3834 mL 1.917 mL 3.8339 mL 7.6678 mL 9.5848 mL
    10 mM 0.1917 mL 0.9585 mL 1.917 mL 3.8339 mL 4.7924 mL
    50 mM 0.0383 mL 0.1917 mL 0.3834 mL 0.7668 mL 0.9585 mL
    100 mM 0.0192 mL 0.0958 mL 0.1917 mL 0.3834 mL 0.4792 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-溴-N-苯基咔唑; 3-Bromo-N-phenylcarbazole CFN90114 1153-85-1 C18H12BrN = 322.20 5mg QQ客服:1457312923
    6-O-咖啡酰基熊果甙; 6-O-Caffeoylarbutin CFN99427 136172-60-6 C21H22O10 = 434.4 5mg QQ客服:215959384
    6,6,9-三甲基-3-丙基苯并[c]苯并吡喃-1-醇; Cannabivarin CFN89306 33745-21-0 C19H22O2 = 282.38 5mg QQ客服:1413575084
    3-O-Acetyl-16 alpha-hydroxytrametenolic acid; 3-O-Acetyl-16 alpha-hydroxytrametenolic acid CFN90804 168293-13-8 C32H50O5 = 514.8 5mg QQ客服:1413575084

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