百两金素A
Ardisiacrispin A
|
产品编号 |
CFN90177 |
CAS编号 |
23643-61-0 |
分子式 = 分子量 |
C52H84O22 = 1061.21 |
产品纯度 |
>=98% |
物理属性 |
White powder |
化合物类型 |
Triterpenoids |
植物来源 |
The herbs of Ardisia crenata. |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
百两金素A |
CFN90177 |
23643-61-0 |
1mg |
QQ客服:215959384 |
百两金素A |
CFN90177 |
23643-61-0 |
5mg |
QQ客服:215959384 |
百两金素A |
CFN90177 |
23643-61-0 |
10mg |
QQ客服:215959384 |
百两金素A |
CFN90177 |
23643-61-0 |
20mg |
QQ客服:215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
National Hellenic Research Foundation (Greece)
Nanjing University of Chinese Medicine (China)
University of Zurich (Switzerland)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Georgia Institute of Technology (USA)
Universidade Católica Portuguesa (Portugal)
Instituto de Investigaciones Agropecuarias (Chile)
Uniwersytet Medyczny w ?odzi (Poland)
Universitas Airlangga (Indonesia)
University of Illinois (USA)
University of Illinois at Chicago (USA)
Universitas islam negeri Jakarta (Indonesia)
Universidad de Antioquia (Colombia)
Yale University (USA)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Appl. Sci.2020, 10(20),7374.
Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
Food and Agriculture Org. Of the UN2019, 151-160
ACS Nano.2018, 12(4):3385-3396
Natural Product Communications2020, doi: 10.1177.
Rev. Chim.2020, 71(3),558-564
Front Plant Sci.2022, 12:811166.
Nutrients.2021, 13(12):4364.
Description: |
Ardisiacrispin A has cytotoxic activity toward HepG2 cancer cell with the GI(50) value of 1.56μM, it could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule.Ardisiacrispin(A+B) exhibit prominent abilities to inhibit the proliferation of HL-60 cells by blocking the cell cycle at S phase and inducing apoptosis. |
Targets: |
HSV |
In vitro: |
J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):739-46. | Pro-apoptotic and microtubule-disassembly effects of ardisiacrispin (A+B), triterpenoid saponins from Ardisia crenata on human hepatoma Bel-7402 cells.[Pubmed: 18696326] | Ardisiacrispin A+Ardisiacrispin B is a mixture of Ardisiacrispin A and ardisiacrispin B, derived from Ardisia crenata with a fixed proportion (2:1). METHODS AND RESULTS: The present study was conducted to investigate its anticancer activity on human cancer cells and its underlying mechanism of action. The (IC50)s of Ardisiacrispin A+Ardisiacrispin B on proliferation of several human cancer cell lines were in the range of 0.9-6.5 microg/ml by sulphorhodamine B-based colorimetric assay, in which Bel-7402 was the most sensitive cell line. Moreover, Ardisiacrispin A+Ardisiacrispin B induced dose-dependent apoptosis in Bel-7402 cells at doses of 1-10 microg/ml by flow cytometry, and resulted in the changes of the mitochondrial membrane depolarization, membrane permeability enhancement, and nuclear condensation in a dose-dependent manner through high-content screening analysis. Furthermore, Ardisiacrispin A+Ardisiacrispin B could disassemble microtubule in Bel-7402 cells; the fluorescence intensity of microtubules decreased at the concentration of 5-20 microg/ml.
CONCLUSIONS:
These findings suggest that Ardisiacrispin A+Ardisiacrispin B could inhibit the proliferation of Bel-7402 cells by inducing apoptosis and disassembling microtubule. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
0.9423 mL |
4.7116 mL |
9.4232 mL |
18.8464 mL |
23.558 mL |
5 mM |
0.1885 mL |
0.9423 mL |
1.8846 mL |
3.7693 mL |
4.7116 mL |
10 mM |
0.0942 mL |
0.4712 mL |
0.9423 mL |
1.8846 mL |
2.3558 mL |
50 mM |
0.0188 mL |
0.0942 mL |
0.1885 mL |
0.3769 mL |
0.4712 mL |
100 mM |
0.0094 mL |
0.0471 mL |
0.0942 mL |
0.1885 mL |
0.2356 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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