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  • 烯丙半胱氨酸

    Allylcysteine

    烯丙半胱氨酸
    产品编号 CFN70312
    CAS编号 21593-77-1
    分子式 = 分子量 C6H11NO2S = 161.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The water-soluble derivative of garlic
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    烯丙半胱氨酸 CFN70312 21593-77-1 1mg QQ客服:2056216494
    烯丙半胱氨酸 CFN70312 21593-77-1 5mg QQ客服:2056216494
    烯丙半胱氨酸 CFN70312 21593-77-1 10mg QQ客服:2056216494
    烯丙半胱氨酸 CFN70312 21593-77-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Parma (Italy)
  • Seoul National University (Korea)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Michigan State University (USA)
  • University of Fribourg (Switzerland)
  • Monash University Sunway Campus (Malaysia)
  • St. Jude Children Research Hospital (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Harvard University (USA)
  • Universitas islam negeri Jakarta (Indonesia)
  • Kyushu University (Japan)
  • The Institute of Cancer Research (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutr Res Pract2019, 13:e45
  • Eur J Pharmacol.2024, 963:176280.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Nutr Cancer.2023, 75(1):376-387.
  • Molecules.2023, 28(4):1526.
  • Babol University of Medical Sciences2024, rs-4289336
  • Anticancer Res.2024, 44(3):1033-1044.
  • Nutraceuticals2022, 2(3),150-161
  • Molecules.2020, 25(18),4089.
  • Molecules2022, 27(14):4601
  • Molecules.2019, 24(23):E4303
  • J Pharm Anal.2016, 6(6):363-373
  • Molecules.2018, 23(7):E1659
  • J Ethnopharmacol.2017, 209:305-316
  • Biomed Pharmacother.2021, 144:112300.
  • Daru.2022, 30(2):273-288.
  • Molecules.2020, 25(23):5609.
  • J Agric Food Chem.2023, 71(47):18510-18523.
  • Nat Commun.2023, 14(1):5075.
  • Biorxiv2019, 10.1101
  • Agronomy 2021, 11(3),502.
  • Antioxidants (Basel).2021, 10(10):1620.
  • Chem Biol Interact.2024, 395:110999.
  • ...
  • 生物活性
    Description: S-allylcysteine has antioxidant and chemopreventive effects. S-allylcysteine is protective in myocardial infarction via an H 2S-related pathway, it mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway, it also ameliorates doxorubicin toxicity in the heart and liver in mice. S-Allylcysteine prevents amyloid-β peptide-induced oxidative stress in rat hippocampus and ameliorates learning deficits
    Targets: GPx | SOD | CPK
    In vivo:
    Free radical biology & medicine, 2003, 35(3):317-324.
    Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage.[Reference: WebLink]
    Acute renal failure (ARF) is a major complication of gentamicin (GM) treatment, which is effective against gram-negative infections. Since experimental evidence suggests a role of reactive oxygen species (ROS) in GM-induced ARF, in this work we studied the effect of a garlic-derived compound, S-allylcysteine (SAC), which is a free radical scavenger, on GM-induced nephrotoxicity.
    METHODS AND RESULTS:
    In rats treated with GM (70 mg/kg/12 h/4 days/s.c.), ARF was evident by the: (i) decrease in creatinine clearance and increase in blood urea nitrogen, (ii) decrease in blood glutathione peroxidase (GPx) activity and increase in urinary excretion of N-acetyl-β-D-glucosaminidase and total protein, and (iii) necrosis of proximal tubular cells. These alterations were prevented by SAC treatment (250 mg/kg/i.p. 24 h before the first dose of GM and 125 mg/kg/12 h/4 days along GM-treatment). Furthermore, SAC prevented the GM-induced oxidative stress (protein carbonyl groups) and the decrease in manganese superoxide dismutase (Mn-SOD), GPx, and glutathione reductase (GR) activities in renal cortex.
    CONCLUSIONS:
    In conclusion, SAC ameliorates the GM-induced ARF by a mechanism related, at least in part, to its ability to decrease oxidative stress and to preserve antioxidant enzymes activity in renal cortex.
    Carcinogenesis, 1996, 17(5):1041-1044.
    Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione S-transferase.[Reference: WebLink]
    Sulfur-containing substances derived from garlic and onion have been shown to prevent experimental carcinogenesis. One of the hypotheses explaining the mechanisms of the chemopreventive activity of these substances is that they activate detoxification systems such as glutathione S-transferase (GST). In this study the effects of S-allylcysteine (SAC), a water-soluble organosulfur compound derived from garlic, on GST activities in the liver, small intestine and colon were investigated. Additionally, we examined SAC for chemopreventive effects on aberrant crypt foci, which are the most likely precursors of colon cancers.
    METHODS AND RESULTS:
    In the rat colonic aberrant crypt assay administration of SAC during the initiation period decreased the number of aberrant crypt foci by 33 and 54% in groups given 40 or 80% maximum tolerated dose (MTD) of SAC respectively. The number of aberrant crypt foci, however, was not changed when SAC was given during the promotion period. GST activity in the liver was increased significantly by 41% 12 h after a single oral administration of 3.5 mmol/kg SAC and this elevated GST level was maintained over a 72 h period. GST levels were increased significantly by the administration of SAC (1.8 mmol/kg/ day for 3 days) not only in the liver but also in the proximal and middle small bowel. Isozyme levels of GST after administration of SAC were also determined using Western blotting. Hepatic GST-alpha and GST-mu were significantly increased by 35 and 42% respectively after oral administration of SAC. GST-pi levels were lower than the detection limit (130 ng/mg/protein) in both the control and SAC-treated groups.
    CONCLUSIONS:
    These results strongly support the previous working hypothesis that SAC exhibits chemopreventive activity by exerting specific effects on carcinogen detoxification systems.
    European journal of pharmacology, 2004, 489(3):197-202.
    S-Allylcysteine prevents amyloid-β peptide-induced oxidative stress in rat hippocampus and ameliorates learning deficits.[Reference: WebLink]

    METHODS AND RESULTS:
    The effects of S-allylcysteine on oxidative damage and spatial learning and memory deficits produced by an intrahippocampal injection of amyloid-beta peptide 25-35 (Abeta(25-35)) in rats were investigated. The formation of reactive oxygen species, lipid peroxidation and the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were all measured in hippocampus 120 min after Abeta(25-35) injection (1 microl of 100 microM solution), while learning and memory skills were evaluated 2 and 35 days after the infusion of Abeta(25-35) to rats, respectively. Abeta(25-35) increased both reactive oxygen species and lipid peroxidation, whereas pretreatment with S-allylcysteine (300 mg/kg, i.p.) 30 min before peptide injection decreased both of these markers. In addition, Abeta(25-35)-induced incorrect learning responses were prevented in most of trials by S-allylcysteine. In contrast, enzyme activities were found unchanged in all groups tested.
    CONCLUSIONS:
    Findings of this work: (i) support the participation of reactive oxygen species in Abeta(25-35)-induced hippocampal toxicity and learning deficits; and (ii) suggest that the protective effects of S-allylcysteine were related to its ability to scavenge reactive oxygen species.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.2035 mL 31.0174 mL 62.0347 mL 124.0695 mL 155.0868 mL
    5 mM 1.2407 mL 6.2035 mL 12.4069 mL 24.8139 mL 31.0174 mL
    10 mM 0.6203 mL 3.1017 mL 6.2035 mL 12.4069 mL 15.5087 mL
    50 mM 0.1241 mL 0.6203 mL 1.2407 mL 2.4814 mL 3.1017 mL
    100 mM 0.062 mL 0.3102 mL 0.6203 mL 1.2407 mL 1.5509 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    常山乙素; Febrifugine CFN92302 24159-07-7 C16H19N3O3 = 301.3 20mg QQ客服:2159513211
    3-Oxo-alpha-ilexanolic acid; 3-Oxo-alpha-ilexanolic acid CFN95496 N/A C30H44O4 = 468.7 5mg QQ客服:2159513211
    新落新妇苷; Neoastilbin CFN91093 54081-47-9 C21H22O11 = 450.40 20mg QQ客服:2056216494
    伸筋草萜宁醇; Lyclaninol CFN98896 53755-76-3 C30H50O4 = 474.7 5mg QQ客服:215959384

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