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  • 阿夫儿茶精

    (+)-Afzelechin

    阿夫儿茶精
    产品编号 CFN98280
    CAS编号 2545-00-8
    分子式 = 分子量 C15H14O5 = 274.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Celastrus orbiculatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    阿夫儿茶精 CFN98280 2545-00-8 1mg QQ客服:3257982914
    阿夫儿茶精 CFN98280 2545-00-8 5mg QQ客服:3257982914
    阿夫儿茶精 CFN98280 2545-00-8 10mg QQ客服:3257982914
    阿夫儿茶精 CFN98280 2545-00-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Tohoku University (Japan)
  • Kitasato University (Japan)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Hamdard University (India)
  • University of Otago (New Zealand)
  • University of Mysore (India)
  • Sri Ramachandra University (India)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Perugia (Italy)
  • Srinakharinwirot University (Thailand)
  • Heidelberg University (Germany)
  • Sant Gadge Baba Amravati University (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Lodz (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plos One.2020, 10.1371
  • Molecules.2019, 24(23):E4303
  • Industrial Crops and Products2017, 95:286-295
  • Molecules.2021, 26(4):816.
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Cell Rep.2022, 39(1):110643.
  • J Food Sci.2021, 86(9):3810-3823.
  • Appl. Sci. 2021, 11(23),11099.
  • J Pharm Biomed Anal2016, 118:183-194
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Genes Genomics.2020, 10.1007
  • Agriculture2022, 12(2),227.
  • Cancer Sci.2022, 113(4):1406-1416.
  • Anticancer Res.2021, 41(3):1357-1364.
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • J Sci Food Agric.2022, 102(4):1628-1639
  • J Ethnopharmacol.2017, 197:157-164
  • Phytomedicine.2019, 61:152813
  • J Nat Med.2021, doi: 10.1007.
  • International J of Green Pharmacy2019, 13(3)
  • Pharm Biol.2022, 60(1):2040-2048.
  • Anal Biochem.2019, 569:10-15
  • ...
  • 生物活性
    Description: (+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM; it also shows moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH) and improves the reduced glutathione levels in rat pancreatic homogenate.(+)-Afzelechin has inhibitory compound of alpha-glucosidase activity, the ID(50) (50% inhibition dose) value is 0.13 mM.
    In vitro:
    Phytochemistry. 2008 Jan;69(2):451-6.
    Antioxidant aryl-prenylcoumarin, flavan-3-ols and flavonoids from Eysenhardtia subcoriacea.[Pubmed: 17892888]

    METHODS AND RESULTS:
    Antioxidant activity (AOA) assay-guided chemical analysis, using a rat pancreas homogenate model, of aerial parts from Eysenhardtia subcoriacea, led to isolation of the new compound subcoriacin (3-(2'-hydroxy-4',5'-methylendioxyphenyl)-6-(3''-hydroxymethyl-4''-hydroxybut-2''-enyl)-7-hydroxycoumarin) together with the known substances: (+)-catechin, (-)-epicatechin, (+)-afzelechin, eriodictyol, (+)-catechin 3-O-beta-D-galactopyranoside and quercetin 3-O-beta-D-galactopyranoside as bioactive constituents. The structure of the compound was determined from 1D and 2D NMR spectroscopic analyses. Additional known constituents were characterized.
    CONCLUSIONS:
    The bioactive compounds showed also moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH). In addition, subcoriacin, (+)-catechin, (-)-epicatechin and (+)-afzelechin improved the reduced glutathione levels in rat pancreatic homogenate.
    Arch Pharm Res. 2005 Jul;28(7):804-9.
    Neuroprotective and free radical scavenging activities of phenolic compounds from Hovenia dulcis.[Pubmed: 16114495]

    METHODS AND RESULTS:
    The EtOAc-soluble fraction from a methanolic extract of Hovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1-8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin (6), 2,3,4-trihydrobenzoic acid (7), and (+)-Afzelechin (8). Among these, compounds 6 and 8 had a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. Furthermore, compound 6 had a DPPH free radical scavenging effect with an IC50 value of 57.7 microM, and a superoxide anion radical scavenging effect with an IC50 value of 8.0 microM. Both compounds 6 and 8 had ABTS cation radical scavenging effects with IC50 values of 7.8 microM and 23.7 microM, respectively.
    CONCLUSIONS:
    These results suggest that compounds 6 and 8 could be neuroprotectants owing to their free radical scavenging activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6456 mL 18.2282 mL 36.4564 mL 72.9129 mL 91.1411 mL
    5 mM 0.7291 mL 3.6456 mL 7.2913 mL 14.5826 mL 18.2282 mL
    10 mM 0.3646 mL 1.8228 mL 3.6456 mL 7.2913 mL 9.1141 mL
    50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.4583 mL 1.8228 mL
    100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7291 mL 0.9114 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    阿夫儿茶精 3-O-木糖苷; Afzelechin 3-O-xyloside CFN89499 512781-45-2 C20H22O9 = 406.38 5mg QQ客服:1457312923
    3,4,4',7-四羟基黄烷; 3,4,4',7-Tetrahydroxyflavan CFN98617 38412-82-7 C15H14O5 = 274.3 5mg QQ客服:2159513211
    儿茶精; 儿茶素; (2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-2H-苯并吡喃-3,5,7-三醇; Catechin CFN99646 154-23-4 C15H14O6 = 290.3 20mg QQ客服:215959384
    水合儿茶素; (+)-Catechin hydrate CFN99568 7295-85-4 C15H14O6.H2O = 308.28 20mg QQ客服:2056216494
    (+)-儿茶素五乙酸酯; 五乙酸儿茶素酯; Catechin pentaacetate CFN99682 16198-01-9 C25H24O11 = 500.5 5mg QQ客服:215959384
    7-木糖苷儿茶酚; 儿茶素 7-木糖苷; Catechin 7-xyloside CFN98665 42830-48-8 C20H22O10 = 422.4 5mg QQ客服:1457312923
    儿茶素-7-O-β-呲喃葡萄糖苷; Catechin 7-O-beta-D-glucopyranoside CFN95524 65597-47-9 C21H24O11 = 452.4 20mg QQ客服:2056216494
    儿茶素-7,3'-二葡萄糖苷; Catechin 7,3'-di-O-beta-D-glucopyranoside CFN95717 105330-53-8 C27H34O16 = 614.6 5mg QQ客服:2056216494
    Symplocoside; Symplocoside CFN95552 76502-76-6 C22H26O11 = 466.4 5mg QQ客服:1457312923
    3-鼠李糖苷儿茶酚;儿茶素 3-鼠李糖苷; Catechin 3-rhamnoside CFN99052 103630-03-1 C21H24O10 = 436.4 5mg QQ客服:1457312923

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