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  • 黄曲霉震颤毒素

    Aflatrem

    黄曲霉震颤毒素
    产品编号 CFN89121
    CAS编号 70553-75-2
    分子式 = 分子量 C32H39NO4 = 501.66
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The secondary metabolites of Aspergillus flavus aswA.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄曲霉震颤毒素 CFN89121 70553-75-2 1mg QQ客服:3257982914
    黄曲霉震颤毒素 CFN89121 70553-75-2 5mg QQ客服:3257982914
    黄曲霉震颤毒素 CFN89121 70553-75-2 10mg QQ客服:3257982914
    黄曲霉震颤毒素 CFN89121 70553-75-2 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Utrecht University (Netherlands)
  • University of Dicle (Turkey)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Northeast Normal University Changchun (China)
  • Imperial College London (United Kingdom)
  • University of Malaya (Malaysia)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Washington State University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Aveiro University (Portugal)
  • Universidade Federal de Santa Catarina (Brazil)
  • Chulalongkorn University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Appl. Sci. 2021, 11(1),14.
  • Molecules.2023, 28(8):3291.
  • FEMS Microbiol Lett.2017, 364(11)
  • Pharmacological Reports2020, 1-9
  • Antioxidants (Basel).2020, 9(6):526.
  • Nutrients2020, 12(3):811.
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • Cytotechnology2022, s10616
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Medicinal Chemistry Research 2021, 30:1117-1124.
  • Int Immunopharmacol.2023, 125:111175.
  • Int J Mol Sci.2023, 24(18):14077.
  • Kasetsart University2022, ethesis.1144.
  • Appl Microbiol Biotechnol.2024, 108(1):207.
  • National University of Pharmacy2022, 1:73-76
  • Biomed Pharmacother.2024, 175:116770.
  • Onco Targets Ther.2017, 10:3467-3474
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Toxins (Basel).2023, 15(3):231.
  • Jurnal Ilmu Pertanian Indonesia2023, 28(4):525-533.
  • ...
  • 生物活性
    Description: Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced chloride current, the potentiating action of aflatrem on the GABAA receptor channel may explain the initial symptoms of intoxication caused by aflatrem in vivo.
    Targets: GABA Receptor
    In vitro:
    Fungal Genet Biol. 2017 Jul;104:29-37.
    Aspergillus flavus aswA, a gene homolog of Aspergillus nidulans oefC, regulates sclerotial development and biosynthesis of sclerotium-associated secondary metabolites.[Pubmed: 28442441]

    METHODS AND RESULTS:
    Aspergillus flavus aswA (AFLA_085170) is a gene encoding a Zn(II)2Cys6 DNA-binding domain and a transcriptional activation domain, DUF3468. Disruption of aswA yielded strains that made a truncated gene transcript and generated a fungus that produced a greatly increased number of sclerotia. These sclerotia were odd-shaped and non-pigmented (white) and different from oval and pigmented (dark brown to black) mature sclerotia. Transcriptomic analysis of the ΔaswA strain grown on potato dextrose agar plates and Wickerham agar plates showed that expression of clustering genes involved in the biosynthesis of three sclerotium-associated secondary metabolites was down-regulated. These included gene clusters of asparasone, Aflatrem, and aflavarin. In contrast, those of aflatoxin, cyclopiazonic acid and kojic acid were not affected.
    CONCLUSIONS:
    Metabolite analyses confirmed that the non-pigmented sclerotia contained aflatoxin and cyclopiazonic acid but not other aforementioned metabolites, three asparasone analogs and dihydroxyaflavinine commonly present in mature sclerotia. Impairment in aswA gene function stalls normal sclerotial development, which in turn prevents biosynthesis and accumulation of sclerotium-specific metabolites.
    Mol Pharmacol. 1989 Mar;35(3):319-23.
    The tremorigen aflatrem is a positive allosteric modulator of the gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes.[Pubmed: 2538710]
    Aflatrem, a mycotoxin from Aspergillus flavus, potentiates the gamma-aminobutyric acid (GABA)-induced chloride current.
    METHODS AND RESULTS:
    This positive allosteric regulatory action of Aflatrem was quantitatively studied on the GABAA receptor channel expressed in Xenopus oocytes after injection with chick brain mRNA under voltage-clamp conditions. In this model system, Aflatrem potentiates the current induced by 5 microM GABA in a concentration-dependent manner. Half-maximal potentiation was obtained with 2.4 microM Aflatrem and maximal stimulation of the GABA (5 microM) response was more than 10-fold. The potentiation was not associated with a change of the reversal potential of the GABA-induced current. In the presence of 2 microM Aflatrem, the GABA dose-response curve shifted to lower concentrations, with the Ka decreasing from 28 to 7 microM and the Hill coefficient, n, from 1.5 to 0.8, as measured at a membrane potential of -100 mV. At saturating concentration of GABA (250 microM), Aflatrem (10 microM) was still able to enhance the current by about 21%. Further experiments suggest that the site of action of Aflatrem on the GABAA receptor channel complex is different from that of benzodiazepines, pentobarbital, and picrotoxin. Aflatrem (10 microM) had no significant effect on the coexpressed voltage-dependent sodium and calcium channels and on the kainate channel.
    CONCLUSIONS:
    The potentiating action of Aflatrem on the GABAA receptor channel may explain the initial symptoms of intoxication caused by Aflatrem in vivo, i.e., diminished activity or immobility of the affected animal.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9934 mL 9.9669 mL 19.9338 mL 39.8676 mL 49.8345 mL
    5 mM 0.3987 mL 1.9934 mL 3.9868 mL 7.9735 mL 9.9669 mL
    10 mM 0.1993 mL 0.9967 mL 1.9934 mL 3.9868 mL 4.9835 mL
    50 mM 0.0399 mL 0.1993 mL 0.3987 mL 0.7974 mL 0.9967 mL
    100 mM 0.0199 mL 0.0997 mL 0.1993 mL 0.3987 mL 0.4983 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苏式-7-O-甲基愈创木基 beta-松柏醇基醚; threo-7-O-Methylguaiacylglycerol beta-coniferyl ether CFN96620 150333-85-0 C21H26O7 = 390.43 5mg QQ客服:215959384
    5,7-二羟基-3',4',5'-三甲氧基黄酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavone CFN96493 18103-42-9 C18H16O7 = 344.32 5mg QQ客服:1413575084
    他拉唑帕利; Talazoparib (BMN 673) CFN60091 1207456-01-6 C19H14F2N6O = 380.35 5mg QQ客服:215959384
    油酸; Oleic acid CFN94800 112-80-1 C18H34O2 = 282.5 20mg QQ客服:215959384

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