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  • 5-Deoxystrigol

    • 5-Deoxystrigol

    5-Deoxystrigol

    5-Deoxystrigol
    		产品编号 CFN89416
    CAS编号 151716-18-6
    分子式 = 分子量 C19H22O5 = 330.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The root exudate of Striga hermonthica (Del.) Benth.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-Deoxystrigol CFN89416 151716-18-6 1mg QQ客服：2159513211
    5-Deoxystrigol CFN89416 151716-18-6 5mg QQ客服：2159513211
    5-Deoxystrigol CFN89416 151716-18-6 10mg QQ客服：2159513211
    5-Deoxystrigol CFN89416 151716-18-6 20mg QQ客服：2159513211
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    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Washington State University (USA)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020, 25(9):2081.
  • Nutr Metab (Lond).2019, 16:31
  • Environ Toxicol.2023, 38(7):1641-1650.
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • iScience.2020, 23(2):100849.
  • Int Immunopharmacol.2019, 71:361-371
  • J Sep Sci.2018, 41(11):2488-2497
  • STAR Protoc.2024, 5(2):102990.
  • Int J Mol Sci.2023, 25(1):283.
  • J Ethnopharmacol.2017, 197:157-164
  • J of Archaeological Science:Reports2024, 53:104298
  • Agriculture.2024, 69(3):140-148.
  • J Biomol Struct Dyn.2022, 1-21.
  • Toxins (Basel).2021, 13(9):593.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Processes2021, 9(1), 153;
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • J Med Food.2021, 24(2):151-160.
  • Molecules.2015, 20(11):20014-30
  • Phytother Res.2022, ptr.7573.
  • Asian J Beauty Cosmetol2024, 22(1): 103-112.
  • J Ethnopharmacol.2019, 244:112074
  • Plants (Basel).2023, 12(5):1120.
  • ...
    • 生物活性
    Description: 5-Deoxystrigol is a highly active Striga germination stimulant. It has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.
    In vitro:
    Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4471-4476.
    Mutation in sorghum LOW GERMINATION STIMULANT 1 alters strigolactones and causes Striga resistance.[Pubmed: 28396420]
    Striga is a major biotic constraint to sorghum production in semiarid tropical Africa and Asia. Genetic resistance to this parasitic weed is the most economically feasible control measure. Mutant alleles at the LGS1 (LOW GERMINATION STIMULANT 1) locus drastically reduce Striga germination stimulant activity.
    METHODS AND RESULTS:
    We provide evidence that the responsible gene at LGS1 codes for an enzyme annotated as a sulfotransferase and show that functional loss of this gene results in a change of the dominant strigolactone (SL) in root exudates from 5-Deoxystrigol, a highly active Striga germination stimulant, to orobanchol, an SL with opposite stereochemistry. Orobanchol, although not previously reported in sorghum, functions in the multiple SL roles required for normal growth and environmental responsiveness but does not stimulate germination of Striga.
    CONCLUSIONS:
    This work describes the identification of a gene regulating Striga resistance and the underlying protective chemistry resulting from mutation.
    In vivo:
    CN 105287502 A[P]. 2016.
    Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury[Reference: WebLink]

    METHODS AND RESULTS:
    The inventor discloses 5-Deoxystrigol which has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.
    CONCLUSIONS:
    Thus, 5-Deoxystrigol can be used in preparation of medicines for preventing and treating liver injury or hepatitis and is disclosed for the first time. As the skeleton type belongs to a brand-new skeleton type and 5-Deoxystrigol has strong therapeutic activity on liver injury, 5-Deoxystrigol has outstanding substantial characteristics and obviously has prominent progress when used in anti-liver injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0269 mL 15.1345 mL 30.2691 mL 60.5382 mL 75.6727 mL
    5 mM 0.6054 mL 3.0269 mL 6.0538 mL 12.1076 mL 15.1345 mL
    10 mM 0.3027 mL 1.5135 mL 3.0269 mL 6.0538 mL 7.5673 mL
    50 mM 0.0605 mL 0.3027 mL 0.6054 mL 1.2108 mL 1.5135 mL
    100 mM 0.0303 mL 0.1513 mL 0.3027 mL 0.6054 mL 0.7567 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-(1-氯-2-羟基-3-甲基-3-丁烯)-7-甲氧基香豆素; 8-(1-Chloro-2-hydroxy-3-methylbut-3-enyl)-7-methoxycoumarin CFN96753 131652-35-2 C15H15ClO4 = 294.73 5mg QQ客服：1457312923
    1''-Hydroxyerythrinin C; 1''-Hydroxyerythrinin C CFN96168 913690-46-7 C20H18O7 = 370.4 5mg QQ客服：215959384
    大黄素; Emodin CFN98834 518-82-1 C15H10O5 = 270.2 20mg QQ客服：1413575084
    AZD5438; AZD5438 CFN60360 602306-29-6 C18H21N5O2S = 371.46 5mg QQ客服：1413575084

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