5-Deoxystrigol

	产品编号	CFN89416
	CAS编号	151716-18-6
	分子式 = 分子量	C₁₉H₂₂O₅ = 330.37
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The root exudate of Striga hermonthica (Del.) Benth.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
5-Deoxystrigol	CFN89416	151716-18-6	1mg	QQ客服：215959384
5-Deoxystrigol	CFN89416	151716-18-6	5mg	QQ客服：215959384
5-Deoxystrigol	CFN89416	151716-18-6	10mg	QQ客服：215959384
5-Deoxystrigol	CFN89416	151716-18-6	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chungnam National University (Korea)

Universiti Sains Malaysia (Malaysia)

Osmania University (India)

Istanbul University (Turkey)

Institute of Chinese Materia Medica (China)

Univerzita Karlova v Praze (Czech Republic)

University of Parma (Italy)

Universidad de Buenos Aires (Argentina)

Harvard University (USA)

The Vancouver Prostate Centre (VPC) (Canada)

Kyushu University (Japan)

University of Beira Interior (Portugal)

University of Vienna (Austria)

University of Limpopo (South Africa)

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Description:

5-Deoxystrigol is a highly active Striga germination stimulant. It has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.

In vitro:

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4471-4476.

Mutation in sorghum LOW GERMINATION STIMULANT 1 alters strigolactones and causes Striga resistance.[Pubmed: 28396420]

Striga is a major biotic constraint to sorghum production in semiarid tropical Africa and Asia. Genetic resistance to this parasitic weed is the most economically feasible control measure. Mutant alleles at the LGS1 (LOW GERMINATION STIMULANT 1) locus drastically reduce Striga germination stimulant activity.
METHODS AND RESULTS:
We provide evidence that the responsible gene at LGS1 codes for an enzyme annotated as a sulfotransferase and show that functional loss of this gene results in a change of the dominant strigolactone (SL) in root exudates from 5-Deoxystrigol, a highly active Striga germination stimulant, to orobanchol, an SL with opposite stereochemistry. Orobanchol, although not previously reported in sorghum, functions in the multiple SL roles required for normal growth and environmental responsiveness but does not stimulate germination of Striga.
CONCLUSIONS:
This work describes the identification of a gene regulating Striga resistance and the underlying protective chemistry resulting from mutation.

In vivo:

CN 105287502 A[P]. 2016.

Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury[Reference: WebLink]

METHODS AND RESULTS:
The inventor discloses 5-Deoxystrigol which has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.
CONCLUSIONS:
Thus, 5-Deoxystrigol can be used in preparation of medicines for preventing and treating liver injury or hepatitis and is disclosed for the first time. As the skeleton type belongs to a brand-new skeleton type and 5-Deoxystrigol has strong therapeutic activity on liver injury, 5-Deoxystrigol has outstanding substantial characteristics and obviously has prominent progress when used in anti-liver injury.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0269 mL	15.1345 mL	30.2691 mL	60.5382 mL	75.6727 mL
5 mM	0.6054 mL	3.0269 mL	6.0538 mL	12.1076 mL	15.1345 mL
10 mM	0.3027 mL	1.5135 mL	3.0269 mL	6.0538 mL	7.5673 mL
50 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.2108 mL	1.5135 mL
100 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.6054 mL	0.7567 mL