5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

	产品编号	CFN96535
	CAS编号	1353676-65-9
	分子式 = 分子量	C₂₆H₂₈O₇ = 452.50
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The barks of Broussonetia papyrifera.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone	CFN96535	1353676-65-9	1mg	QQ客服：2056216494
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone	CFN96535	1353676-65-9	5mg	QQ客服：2056216494
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone	CFN96535	1353676-65-9	10mg	QQ客服：2056216494
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone	CFN96535	1353676-65-9	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Worcester Polytechnic Institute (USA)

University of Minnesota (USA)

The Australian National University (Australia)

Korea Intitute of Science and Technology (KIST) (Korea)

Donald Danforth Plant Science Center (USA)

University of Pretoria (South Africa)

University of Toulouse (France)

Funda??o Universitária de Desenvolvimento (Brazil)

University of Eastern Finland (Finland)

Heidelberg University (Germany)

Charles Sturt University (Denmark)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Mendel University in Brno (Czech Republic)

Kyoto University (Japan)

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Description:

5,7,3′,4′-Tetrahydroxy-3-methoxy-8,5′-diprenylflavone has anti-cancer activity, it shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro, with the IC50 value of 4.41 uM. 5,7,3′,4′-Tetrahydroxy-3-methoxy-8,5′-diprenylflavone can strongly down-regulate expression concentrations of estrogen receptor-α (ER-α) and is able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.

Targets:

Estrogen receptor | Progestogen receptor

In vitro:

Phytochemistry Letters, 2013, 6(3):331-336.

Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo.[Reference: WebLink]

METHODS AND RESULTS:
Two new prenylflavones 5,7,3′,4′-tetrahydroxy-3-methoxy-8-geranylflavone (1) and 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone (2), as well as four known ones, uralenol (3), papyriflavonol A (4), broussoflavonol B (5) and broussochalcone A (6) were isolated and purified from an ethyl acetate-soluble extract of the barks of Broussonetia papyrifera. Their structures were determined with the spectroscopic methods including HR-EI-MS, 1D and 2D NMR. We found that compounds 2–6 showed potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. The IC50 values of compounds 2 and 5 were 4.41 and 4.19 μM respectively after the treatment of 72 h. We also found that compounds 2 and 5 strongly down-regulated expression concentrations of estrogen receptor-α (ER-α) and were able to inhibit tumor growth in a xenograft model of the human breast cancer line BCAP-37 in vivo.
CONCLUSIONS:
Our results demonstrated that prenylflavones from B. Papyrifera exhibit potent anti-tumor activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
6-异戊烯基槲皮素-3-甲醚; 6-Prenylquercetin-3-methylether	CFN91982	151649-34-2	C₂₁H₂₀O₇ = 384.38	5mg	QQ客服：2056216494
5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone; 5,7,3',4'-Tetrahydroxy-3-methoxy-8-geranylflavone	CFN96534	1605304-56-0	C₂₆H₂₈O₇ = 452.50	5mg	QQ客服：215959384
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone; 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone	CFN96535	1353676-65-9	C₂₆H₂₈O₇ = 452.50	5mg	QQ客服：1457312923
甘草黄酮醇A; Glycyrrhiza flavonol A	CFN91979	197304-01-1	C₂₀H₁₈O₇ = 370.35	5mg	QQ客服：2056216494
车桑子素 I; Dodoviscin I	CFN96015	1372527-40-6	C₂₁H₂₂O₇ = 386.4	5mg	QQ客服：215959384
Aliarin; Aliarin	CFN96008	84294-77-9	C₂₂H₂₄O₈ = 416.4	5mg	QQ客服：1413575084
5,7-二羟基-2-[4-羟基-3-(3-甲基-2-丁烯-1-基)苯基]-3,6-二甲氧基-4H-1-苯并吡喃-4-酮; 5,7,4-Trihydroxy-3,6-dimethoxy-3-prenylflavone	CFN97995	959421-20-6	C₂₂H₂₂O₇ = 398.4	5mg	QQ客服：215959384
Dodovisone D ; Dodovisone D	CFN96560	1616683-53-4	C₂₂H₂₂O₈ = 414.41	5mg	QQ客服：1413575084
Dodovisone A; Dodovisone A	CFN96526	1616683-50-1	C₂₇H₃₀O₈ = 482.53	5mg	QQ客服：1413575084
Dodovisone B; Dodovisone B	CFN96556	1616683-51-2	C₂₇H₃₂O₉ = 500.54	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2099 mL	11.0497 mL	22.0994 mL	44.1989 mL	55.2486 mL
5 mM	0.442 mL	2.2099 mL	4.4199 mL	8.8398 mL	11.0497 mL
10 mM	0.221 mL	1.105 mL	2.2099 mL	4.4199 mL	5.5249 mL
50 mM	0.0442 mL	0.221 mL	0.442 mL	0.884 mL	1.105 mL
100 mM	0.0221 mL	0.1105 mL	0.221 mL	0.442 mL	0.5525 mL