3'-去甲川陈皮素

3'-Demethylnobiletin

	产品编号	CFN93130
	CAS编号	112448-39-2
	分子式 = 分子量	C₂₀H₂₀O₈ = 388.37
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The peels of Citrus nobilis Lour.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
3'-去甲川陈皮素	CFN93130	112448-39-2	1mg	QQ客服：215959384
3'-去甲川陈皮素	CFN93130	112448-39-2	5mg	QQ客服：215959384
3'-去甲川陈皮素	CFN93130	112448-39-2	10mg	QQ客服：215959384
3'-去甲川陈皮素	CFN93130	112448-39-2	20mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

Description:

3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death. It significantly suppresses CD36 expression.

Targets:

LDL | LOX | AP-1 | NF-kB

In vitro:

Biofactors. 2007;31(2):107-16.

Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.[Pubmed: 18806314]

Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs) is a key event in atherosclerosis. We previously reported that nobiletin (NOB), a citrus polymethoxylated flavone, markedly reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced SRs and adhesion molecules mRNA expression and blockade of DiI-acLDL uptake in THP-1 human monocyte-like cells.
METHODS AND RESULTS:
In this study, we examined the effects of NOB metabolites, 3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone (3'-demethyl-NOB,3'-Demethylnobiletin ), 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (4'-demethyl-NOB) and 3', 4'-dihydroxy-5,6,7,8,-tetramethoxyflavone (3', 4'-didemethyl-NOB) and NOB analog, tangeretin, on SRs and adhesion molecules mRNA expression. 3'-Demethyl-NOB(3'-Demethylnobiletin ) significantly suppressed CD36 expression, moreover, 4'-demethyl- and 3', 4'-didemethyl-NOB significantly suppressed TPA-induced expression of SR-A and LOX-1. Further, the suppressive effects of 4'-demethyl- and 3', 4'-didemethyl-NOB on the expression of CD36 mRNA were greater extent than parent NOB. The inhibitory effects of the metabolites toward TPA-induced SR mRNA expression are partly associated with the suppression of AP-1 and NF-kappaB transcriptional activities.
CONCLUSIONS:
Together, our results suggest that metabolites of NOB, such as 4'-demethyl- and 3', 4'-didemethyl-NOB, have comparable or higher potentials to attenuate SR expression than NOB.

In vivo:

Mol Nutr Food Res. 2015 Dec;59(12):2383-94.

Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis.[Pubmed: 26445322 ]

Nobiletin (NBT) is a major citrus flavonoid with various health benefits. Herein, we investigated the colon cancer chemopreventive effects of NBT and its colonic metabolites in a colitis-associated colon carcinogenesis mouse model as well as in human colon cancer cell models.
METHODS AND RESULTS:
In azoxymethane/dextran sulfate sodium treated mice, oral administration of NBT effectively decreased both incidence and multiplicity of colonic tumors. NBT showed significant antiproliferative, proapoptotic, and anti-inflammatory effects in the mouse colon. HPLC analysis revealed that oral administration of NBT resulted in high levels of metabolites, i.e. 3'-Demethylnobiletin (M1), 4'-demethylnobiletin (M2), and 3',4'-didemethylnobiletin (M3) in the colonic mucosa. In contrast, the colonic level of NBT was about 20-fold lower than the total colonic level of three metabolites. Cell culture studies demonstrated that the colonic metabolites of NBT significantly inhibited the growth of human colon cancer cells, caused cell-cycle arrest, induced apoptosis, and profoundly modulated signaling proteins related with cell proliferation and cell death. All of these effects were much stronger than those produced by NBT alone.
CONCLUSIONS:
Our results demonstrated that oral administration of NBT significantly inhibited colitis-associated colon carcinogenesis in mice, and this chemopreventive effect was strongly associated with its colonic metabolites.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5749 mL	12.8743 mL	25.7486 mL	51.4973 mL	64.3716 mL
5 mM	0.515 mL	2.5749 mL	5.1497 mL	10.2995 mL	12.8743 mL
10 mM	0.2575 mL	1.2874 mL	2.5749 mL	5.1497 mL	6.4372 mL
50 mM	0.0515 mL	0.2575 mL	0.515 mL	1.0299 mL	1.2874 mL
100 mM	0.0257 mL	0.1287 mL	0.2575 mL	0.515 mL	0.6437 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
厄弗酚; Effusol	CFN90815	73166-28-6	C₁₇H₁₆O₂ = 252.3	10mg	QQ客服：215959384
小堆心菊素C; Microhelenin C	CFN91997	63569-07-3	C₂₀H₂₆O₅ = 346.42	5mg	QQ客服：3257982914
Teuclatriol; Teuclatriol	CFN99634	152110-17-3	C₁₅H₂₈O₃ = 256.4	5mg	QQ客服：3257982914
C-藜芦酰乙二醇; C-Veratroylglycol	CFN99804	168293-10-5	C₁₀H₁₂O₅ = 212.2	5mg	QQ客服：2056216494

3'-去甲川陈皮素

3'-Demethylnobiletin

信息支持

联系方式