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  • 3'-去甲川陈皮素

    3'-Demethylnobiletin

    3'-去甲川陈皮素
    产品编号 CFN93130
    CAS编号 112448-39-2
    分子式 = 分子量 C20H20O8 = 388.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus nobilis Lour.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3'-去甲川陈皮素 CFN93130 112448-39-2 1mg QQ客服:1413575084
    3'-去甲川陈皮素 CFN93130 112448-39-2 5mg QQ客服:1413575084
    3'-去甲川陈皮素 CFN93130 112448-39-2 10mg QQ客服:1413575084
    3'-去甲川陈皮素 CFN93130 112448-39-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chang Gung University (Taiwan)
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  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Colorado State University (USA)
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  • Warszawski Uniwersytet Medyczny (Poland)
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  • Universita' Degli Studi Di Cagliari (Italy)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Viruses.2021, 13(11):2118.
  • International Food Research Journal2018, 25(6):2560-2571
  • Biomed Pharmacother.2020, 128:110318.
  • BMC Complement Altern Med.2016, 16:213
  • Antioxidants (Basel).2020, 9(2): E119
  • Appl. Sci. 2021, 11(22), 10552
  • ScientificWorldJournal.2022, 2022:4806889.
  • Toxins (Basel).2020, 12(4):210.
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Nutrients.2023, 15(6):1417.
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • Regen Biomater.2023, 10:rbad077.
  • Phytother Res.2016, 30(12):2020-2026
  • Mol Pharm.2018, 15(8):3285-3296
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Plant Archives2020, 2(1),2929-2934
  • Sci Rep.2017, 7(1):3249
  • iScience.2023, 26(9):107602.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • J Chromatogr A.2022, 1685:463640.
  • Molecules.2017, 22(6)
  • ...
  • 生物活性
    Description: 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling proteins related with cell proliferation and cell death. It significantly suppresses CD36 expression.
    Targets: LDL | LOX | AP-1 | NF-kB
    In vitro:
    Biofactors. 2007;31(2):107-16.
    Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.[Pubmed: 18806314]
    Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs) is a key event in atherosclerosis. We previously reported that nobiletin (NOB), a citrus polymethoxylated flavone, markedly reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced SRs and adhesion molecules mRNA expression and blockade of DiI-acLDL uptake in THP-1 human monocyte-like cells.
    METHODS AND RESULTS:
    In this study, we examined the effects of NOB metabolites, 3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone (3'-demethyl-NOB,3'-Demethylnobiletin ), 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (4'-demethyl-NOB) and 3', 4'-dihydroxy-5,6,7,8,-tetramethoxyflavone (3', 4'-didemethyl-NOB) and NOB analog, tangeretin, on SRs and adhesion molecules mRNA expression. 3'-Demethyl-NOB(3'-Demethylnobiletin ) significantly suppressed CD36 expression, moreover, 4'-demethyl- and 3', 4'-didemethyl-NOB significantly suppressed TPA-induced expression of SR-A and LOX-1. Further, the suppressive effects of 4'-demethyl- and 3', 4'-didemethyl-NOB on the expression of CD36 mRNA were greater extent than parent NOB. The inhibitory effects of the metabolites toward TPA-induced SR mRNA expression are partly associated with the suppression of AP-1 and NF-kappaB transcriptional activities.
    CONCLUSIONS:
    Together, our results suggest that metabolites of NOB, such as 4'-demethyl- and 3', 4'-didemethyl-NOB, have comparable or higher potentials to attenuate SR expression than NOB.
    In vivo:
    Mol Nutr Food Res. 2015 Dec;59(12):2383-94.
    Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesis.[Pubmed: 26445322 ]
    Nobiletin (NBT) is a major citrus flavonoid with various health benefits. Herein, we investigated the colon cancer chemopreventive effects of NBT and its colonic metabolites in a colitis-associated colon carcinogenesis mouse model as well as in human colon cancer cell models.
    METHODS AND RESULTS:
    In azoxymethane/dextran sulfate sodium treated mice, oral administration of NBT effectively decreased both incidence and multiplicity of colonic tumors. NBT showed significant antiproliferative, proapoptotic, and anti-inflammatory effects in the mouse colon. HPLC analysis revealed that oral administration of NBT resulted in high levels of metabolites, i.e. 3'-Demethylnobiletin (M1), 4'-demethylnobiletin (M2), and 3',4'-didemethylnobiletin (M3) in the colonic mucosa. In contrast, the colonic level of NBT was about 20-fold lower than the total colonic level of three metabolites. Cell culture studies demonstrated that the colonic metabolites of NBT significantly inhibited the growth of human colon cancer cells, caused cell-cycle arrest, induced apoptosis, and profoundly modulated signaling proteins related with cell proliferation and cell death. All of these effects were much stronger than those produced by NBT alone.
    CONCLUSIONS:
    Our results demonstrated that oral administration of NBT significantly inhibited colitis-associated colon carcinogenesis in mice, and this chemopreventive effect was strongly associated with its colonic metabolites.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5749 mL 12.8743 mL 25.7486 mL 51.4973 mL 64.3716 mL
    5 mM 0.515 mL 2.5749 mL 5.1497 mL 10.2995 mL 12.8743 mL
    10 mM 0.2575 mL 1.2874 mL 2.5749 mL 5.1497 mL 6.4372 mL
    50 mM 0.0515 mL 0.2575 mL 0.515 mL 1.0299 mL 1.2874 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.515 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
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