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  • 3,5-二羟基苯甲酸

    3,5-Dihydroxybenzoic acid

    3,5-二羟基苯甲酸
    产品编号 CFN70235
    CAS编号 99-10-5
    分子式 = 分子量 C7H6O4 = 154.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of wheat.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    3,5-二羟基苯甲酸 CFN70235 99-10-5 10mg QQ客服:2159513211
    3,5-二羟基苯甲酸 CFN70235 99-10-5 20mg QQ客服:2159513211
    3,5-二羟基苯甲酸 CFN70235 99-10-5 50mg QQ客服:2159513211
    3,5-二羟基苯甲酸 CFN70235 99-10-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • National Cancer Center Research Institute (Japan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2016, 21(6)
  • Nutr Cancer.2023, 75(1):376-387.
  • Natural Product Sciences2023, 29(4):276-280.
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Front Immunol.2018, 9:2091
  • Int J Mol Sci.2023, 24(8):7442.
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  • Dent Mater J. 2024, dmj.2023-294.
  • Industrial Crops and Products2021, 163:113313.
  • Food Chem X.2024, 21:101127.
  • Journal of Holistic Integrative Pharmacy2024, 5(1):45-55.
  • Toxicol In Vitro.2023, 86:105521.
  • J Ethnopharmacol.2017, 196:75-83
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • Industrial Food Engineering2015, 19(4):408-413
  • Molecules.2019, 24(19):E3417
  • Front Cell Dev Biol.2021, 9:588093.
  • Molecules.2023, 28(10):4121.
  • Microb Pathog.2024, 189:106609.
  • J Ethnopharmacol.2022, 291:115159.
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  • Biomedicines.2022, 10(5):1170
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  • ...
  • 生物活性
    Description: 3,5-Dihydroxybenzoic acid, a specific agonist for Hydroxycarboxylic Acid 1, inhibits lipolysis in adipocytes.
    In vivo:
    Journal of Pharmacology & Experimental Therapeutics, 2012, 341(3):794-801.
    3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes.[Reference: WebLink]
    Niacin raises high-density lipoprotein and lowers low-density lipoprotein through the activation of the β-hydroxybutyrate receptor hydroxycarboxylic acid 2 (HCA2) (aka GPR109a) but with an unwanted side effect of cutaneous flushing caused by vascular dilation because of the stimulation of HCA2 receptors in Langerhans cells in skin. HCA1 (aka GPR81), predominantly expressed in adipocytes, was recently identified as a receptor for lactate. Activation of HCA1 in adipocytes by lactate results in the inhibition of lipolysis, suggesting that agonists for HCA1 may be useful for the treatment of dyslipidemia. Lactate is a metabolite of glucose, suggesting that HCA1 may also be involved in the regulation of glucose metabolism. The low potency of lactate to activate HCA1, coupled with its fast turnover rate in vivo, render it an inadequate tool for studying the biological role of lactate/HCA1 in vivo.
    METHODS AND RESULTS:
    In this article, we demonstrate the identification of 3-hydroxybenzoic acid (3-HBA) as an agonist for both HCA2 and HCA1, whereas 3,5-dihydroxybenzoic acid (3,5-DHBA) is a specific agonist for only HCA1 (EC(50) ∼150 μM). 3,5-DHBA inhibits lipolysis in wild-type mouse adipocytes but not in HCA1-deficient adipocytes.
    CONCLUSIONS:
    Therefore, 3,5-DHBA is a useful tool for the in vivo study of HCA1 function and offers a base for further HCA1 agonist design. Because 3-HBA and 3,5-DHBA are polyphenolic acids found in many natural products, such as fruits, berries, and coffee, it is intriguing to speculate that other heretofore undiscovered natural substances may have therapeutic benefits.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.4893 mL 32.4465 mL 64.8929 mL 129.7859 mL 162.2323 mL
    5 mM 1.2979 mL 6.4893 mL 12.9786 mL 25.9572 mL 32.4465 mL
    10 mM 0.6489 mL 3.2446 mL 6.4893 mL 12.9786 mL 16.2232 mL
    50 mM 0.1298 mL 0.6489 mL 1.2979 mL 2.5957 mL 3.2446 mL
    100 mM 0.0649 mL 0.3245 mL 0.6489 mL 1.2979 mL 1.6223 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异苦参酮; Isokurarinone CFN90766 52483-02-0 C26H30O6 = 438.5 10mg QQ客服:3257982914
    清风藤碱; Sinoacutine CFN98640 4090-18-0 C19H21NO4 = 327.4 5mg QQ客服:2056216494
    4'-O-甲基根皮素 ; Asebogenin CFN96928 520-42-3 C16H16O5 = 288.29 5mg QQ客服:2159513211
    Octadecyl p-coumarate ; Octadecyl p-coumarate CFN96932 72943-88-5 C27H44O3 = 416.64 5mg QQ客服:2056216494

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