3,3',5-三碘-L-甲腺原氨酸钠盐
3,3'',5-Triiodo-L-thyronine Sodium Salt
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 3,3',5-三碘-L-甲腺原氨酸钠盐 |
CFN90069 |
55-06-1 |
10mg |
QQ客服：1457312923 |
| 3,3',5-三碘-L-甲腺原氨酸钠盐 |
CFN90069 |
55-06-1 |
20mg |
QQ客服：1457312923 |
| 3,3',5-三碘-L-甲腺原氨酸钠盐 |
CFN90069 |
55-06-1 |
50mg |
QQ客服：1457312923 |
| 3,3',5-三碘-L-甲腺原氨酸钠盐 |
CFN90069 |
55-06-1 |
100mg |
QQ客服：1457312923 |
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Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M), a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. |
| Targets: |
Estrogen receptor | Antifection | Progestogen receptor |
| In vivo: |
| J Vasc Res. 2014;51(5):350-9. | | Vascular function of the mesenteric artery isolated from thyroid hormone receptor-α knockout mice.[Pubmed: 25500991] | This study evaluated the consequences of thyroid hormone receptor-α (TRα) disruption on vascular reactivity.
METHODS AND RESULTS:
The activity of superior mesenteric arteries isolated from TRα knockout mice generated in the SV129 background (TRα(0/0)SV) or in a pure C57BL/6 background (TRα(0/0)C57) was compared to that of their corresponding wild-type strains (SV129 or C57BL/6 mice).
The wild-type SV129 mice exhibited an impaired acetylcholine (Ach)-induced mesenteric artery relaxation compared to C57BL/6 mice, associated with greater responses to angiotensin II (AII) and phenylephrine (PE). The disruption of TRα decreased the vascular response to sodium nitroprusside and PE in both the SV129 and C57BL/6 genetic backgrounds. Responses to Ach and AII were also blunted, but only in TRα(0/0)C57 mice. The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M); a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. However, the response to T3 was nearly absent in TRα(0/0)C57 mice.
CONCLUSIONS:
TRα is essential for the control of vascular tone, particularly in thyroid hormone-mediated relaxation. The difference in response to Ach observed between the two wild-type mice should be taken into account for interpreting the vascular responses of genetically engineered mice. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.486 mL |
7.4299 mL |
14.8597 mL |
29.7194 mL |
37.1493 mL |
| 5 mM |
0.2972 mL |
1.486 mL |
2.9719 mL |
5.9439 mL |
7.4299 mL |
| 10 mM |
0.1486 mL |
0.743 mL |
1.486 mL |
2.9719 mL |
3.7149 mL |
| 50 mM |
0.0297 mL |
0.1486 mL |
0.2972 mL |
0.5944 mL |
0.743 mL |
| 100 mM |
0.0149 mL |
0.0743 mL |
0.1486 mL |
0.2972 mL |
0.3715 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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