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  • 仲辛酮

    2-Octanone

    仲辛酮
    产品编号 CFN70024
    CAS编号 111-13-7
    分子式 = 分子量 C8H16O = 128.2
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The oil of Castor
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    仲辛酮 CFN70024 111-13-7 10mg QQ客服:215959384
    仲辛酮 CFN70024 111-13-7 20mg QQ客服:215959384
    仲辛酮 CFN70024 111-13-7 50mg QQ客服:215959384
    仲辛酮 CFN70024 111-13-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(2):E99
  • Front Plant Sci.2021, 12:673337.
  • Front Plant Sci.2017, 8:723
  • Clin Transl Med.2021, 11(5):e392.
  • Chinese Medicine2019, 14(1)
  • Molecules.2023, 28(13):4971.
  • iScience.2024, 4790628.
  • Journal of Functional Foods2023, 104:105542
  • Analytical Letters 2021, 54(4).
  • J of Applied Biological Chem.2020, 63(2):147-152
  • World J Mens Health.2019, 10.5534
  • Front Nutr.2023, 10:1181135.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Cell Rep.2020, 32(11):108158.
  • Food Chem.2024, 436:137768.
  • Int J Biol Macromol.2018, 112:1093-1103
  • Oncol Lett.2020, 20(4):122.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Invest New Drugs.2017, 35(2):166-179
  • Eur J Pharmacol.2020, 889:173589.
  • Current Topics in Nutraceutical Research2021, 19(1),p90-105.
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Molecules.2020, 25(23):5609.
  • ...
  • 生物活性
    Description: 2-Hexanol has neurotoxic potency.
    In vitro:
    Sangyō igaku. Japanese journal of industrial health, 1982, 24(5):475-484.
    An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane.[Pubmed: 6296504]
    An electrophysiological study of the neurotoxicity of 2-octanone (an analogue of methyl n-butyl ketone) and 2-hexanol (a metabolite of n-hexane) was conducted on rats as a part of the study to determine the specific molecular arrangement required for the development of peripheral neuropathy.
    METHODS AND RESULTS:
    The compound 2-octanone or 2-hexanol was administered subcutaneously in the daily dose of 400 mg/kg of each compound into the back of seven rats, weighing 290 g, 5 days per week for a period of 21 weeks. Animals treated with 2-octanone for 21 weeks failed to exhibit apparent clinical and neurophysiological evidence except a slight inhibition of weight gain and narcotic effects after treatment with the compound. The same doses of 2-hexanol for 21 weeks caused hypersalivation, gait disturbances, crossing phenomena of hind limbs and a failure of normal growth. Retardation of the conduction velocity in the motor and sensory nerve fibers and the prolonged motor latencies of the tail nerves (distal part) began to appear at the 14th week of the experiment when 9.6 g in the total dose had been given to each animal. These changes were intensified in the subsequent course of the experiment. Our previous experiments and the present results showed that n-hexane barely produced peripheral neuropathy in doses over 10.5 g, and that 2-hexanone (MBK), 2,5-hexanediol or 2,5-hexanedione never failed to produce a neuropathy even in doses less than 9.6 g of each compound.
    CONCLUSIONS:
    The above results suggest that the neurotoxic potency of 2-hexanol is greater than that of n-hexane but less than that of MBK, 2,5-hexanediol or 2,5-hexanedione.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 7.8003 mL 39.0016 mL 78.0031 mL 156.0062 mL 195.0078 mL
    5 mM 1.5601 mL 7.8003 mL 15.6006 mL 31.2012 mL 39.0016 mL
    10 mM 0.78 mL 3.9002 mL 7.8003 mL 15.6006 mL 19.5008 mL
    50 mM 0.156 mL 0.78 mL 1.5601 mL 3.1201 mL 3.9002 mL
    100 mM 0.078 mL 0.39 mL 0.78 mL 1.5601 mL 1.9501 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    对羟基苯乙酮; 4'-Hydroxyacetophenone CFN97575 99-93-4 C8H8O2 = 136.2 20mg QQ客服:1413575084
    3,7,23,24-tetrahydroxycucurbita-5,25-dien-19-al; 3,7,23,24-tetrahydroxycucurbita-5,25-dien-19-al CFN95168 1446447-97-7 C30H48O5 = 488.7 5mg QQ客服:3257982914
    8-(7-羟基-3,7-二甲基-2,5-辛二烯氧基)补骨脂素; 8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen CFN99485 144398-34-5 C21H22O5 = 354.4 5mg QQ客服:3257982914
    丁香亭-3-O-葡糖苷; Syringetin-3-O-glucoside CFN90468 40039-49-4 C23H24O13 = 508.43 5mg QQ客服:2056216494

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