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  • 2',3'-二羟基-4'-甲氧基苯乙酮

    • 2',3'-二羟基-4'-甲氧基苯乙酮

    2',3'-Dihydroxy-4'-methoxyacetophenone

    2',3'-二羟基-4'-甲氧基苯乙酮
    		产品编号 CFN96861
    CAS编号 708-53-2
    分子式 = 分子量 C9H10O4 = 182.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Cynenchum paniculatum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2',3'-二羟基-4'-甲氧基苯乙酮 CFN96861 708-53-2 10mg QQ客服：3257982914
    2',3'-二羟基-4'-甲氧基苯乙酮 CFN96861 708-53-2 20mg QQ客服：3257982914
    2',3'-二羟基-4'-甲氧基苯乙酮 CFN96861 708-53-2 50mg QQ客服：3257982914
    2',3'-二羟基-4'-甲氧基苯乙酮 CFN96861 708-53-2 100mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Medical University of South Carolina (USA)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2024, 446:138870.
  • Plants (Basel).2023, 12(1):163.
  • Braz J Biol.2023, 82:e266573.
  • Food Bioscience2023, 52:102412
  • Toxicological Research2020, doi: 10.1007.
  • J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
  • Foods.2021, 10(12):2929.
  • J Clin Med.2019, 8(10):E1664
  • Molecules.2019, 24(16):E3003
  • Srinagarind Medical Journal2019, 34(1)
  • J Food Drug Anal.2023, 31(2):254-277.
  • Korean J Acupunct2020, 37:104-121
  • Biol Pharm Bull.2018, 41(1):65-72
  • Drug Dev Res.2020, doi: 10.1002
  • J Biomed Sci.2020, 27(1):60.
  • Int J Mol Sci.2023, 25(1):162.
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • J Med Food.2021, 24(3):209-217.
  • Food Analytical Methods2017, 10:3225-3234
  • BMC Plant Biol.2023, 23(1):239.
  • Molecules.2020, 25(20):4851.
  • PLoS One.2018, 13(3):e0193386
  • Food Chem.2016, 191:81-90
  • ...
    • 生物活性
    Description: 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
    Targets: Calcium Channel
    In vitro:
    Bioorg Med Chem Lett. 2013 Dec 15;23(24):6732-6.
    The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.[Pubmed: 24210692]
    We isolated 2,3-dihydroxy-4-methoxyacetophenone, a neuroprotective compound from Cynenchum paniculatum in our previous study.
    METHODS AND RESULTS:
    The present study was conducted to investigate the possible neuroprotective effect of 2,3-dihydroxy-4-methoxyacetophenone that has been previously isolated from Cynenchum paniculatum on hippocampal neuronal cell line, HT22 cells and its possible cognitive-enhancing effect on scopolamine-induced amnesia in mice. Neuroprotective effect against glutamate-induced neurotoxicity in HT22 cells was evaluated by MTT assay. Also, cognitive enhancing effect against scopolamine (1mg/kg, ip) induced learning and memory deficit was measured by Morris water maze test. Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine. In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine. 2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM). Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity. The results showed that 2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity.
    CONCLUSIONS:
    We suggest that 2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.4894 mL 27.4469 mL 54.8938 mL 109.7876 mL 137.2345 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL 21.9575 mL 27.4469 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL 10.9788 mL 13.7234 mL
    50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.1958 mL 2.7447 mL
    100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.0979 mL 1.3723 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Yucalexin P-17; Yucalexin P-17 CFN96300 119642-82-9 C20H30O3 = 318.5 5mg QQ客服：215959384
    12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid; 12beta-Acetoxy-3,7,11,15,23-pentaoxo-lanost-8,20-dien-26-oic acid CFN95505 1309931-91-6 C32H40O9 = 568.7 5mg QQ客服：2056216494
    猪毛蒿-3-半乳糖苷; Eupalitin 3-galactoside CFN70347 35399-32-7 C23H24O12 = 492.4 5mg QQ客服：3257982914
    新化合物15; New compound 15 CFN95413 N/A C31H46O6 = 514.7 5mg QQ客服：2159513211

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