| In vitro: |
| Journal of Computational & Theoretical Nanoscience, 2014, 20(7):1463-1467. | | Phytochemical Analysis and Growth Inhibiting Effects of Salix viminalis L. Leaves Against Different Candida Isolates.[Reference: WebLink] | Plants have been the inherent part of life since ancient times, there is a very close relationship between humans and plants. As a medicine plants have always been used since existence of life on this planet. Current study was designed to identify phytoconstituents composition and growth inhibiting effects of leaves extract of Salix viminalis L. against Candida glabrata, Candida guilliermondii and Candida parapsilosis.
METHODS AND RESULTS:
Phytochemical tests showed the presence of glycosides, phenols, steroids, alkaloids, terpenoids, flavanoids and tannins. By GC-MS analysis fifty two chemical constituents were analyzed in which 1-Heptacosanol (8.99%), Hexadecanoic acid (7.86%), Cholesterin (7.42%), Palmitic acid, methyl ester (5.49%), 1,2-Cyclohexanediol (4.96%), and Phytol (4.39%) were the major chemical constituents. The test extract has shown significant anticandidal activity against all Candida species. Scanning electron microscopy micrographs (SEM) showed ultrastructural changes in treated Candida cells.
CONCLUSIONS:
Antifungal results revealed that methanolic extract of S. viminalis leaves can be used as a raw material for future anti-candidal drugs. |
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